Diagnostic Methods for the Prediction of Therapeutic Success, Recurrence Free and Overall Survival in Cancer Therapy
First Claim
1. A method for predicting therapeutic success of a given mode of treatment in a patient having cancer or for adapting therapeutic regimen based on individualized risk assessment for a patient having cancer, comprising(a) obtaining a biological sample from said patient;
- (b) determining the pattern of expression levels of at least one marker gene of the group of marker genes listed in Table 1;
(c) comparing the pattern of expression levels determined in (b) with one or several reference pattern(s) of expression levels; and
(d) predicting therapeutic success for said given mode of treatment in said subject or implementing therapeutic regimen targeting said marker genes in said subject from the outcome of the comparison in step (c).
2 Assignments
0 Petitions
Accused Products
Abstract
Described are 12 human genes which are differentially expressed in neoplastic tissues of patients responding well to treatment as compared to patients not responding well as determined by overall survival time in the non responding cohort. Moreover, methods for prognosis of the therapeutic success in cancer therapy are described. These methods are based on determination of expression levels of particular genes which are differentially expressed in cancer patients, preferably the genes encoding VEGFC, ERBB3 and Her2/neu, prior to the onset of anti-cancer chemotherapy. These methods are particularly useful in the investigation of advanced head and neck cancer, but are useful in the investigation of other types of cancer and therapies as well.
-
Citations
18 Claims
-
1. A method for predicting therapeutic success of a given mode of treatment in a patient having cancer or for adapting therapeutic regimen based on individualized risk assessment for a patient having cancer, comprising
(a) obtaining a biological sample from said patient; -
(b) determining the pattern of expression levels of at least one marker gene of the group of marker genes listed in Table 1; (c) comparing the pattern of expression levels determined in (b) with one or several reference pattern(s) of expression levels; and (d) predicting therapeutic success for said given mode of treatment in said subject or implementing therapeutic regimen targeting said marker genes in said subject from the outcome of the comparison in step (c). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 15, 16, 17, 18)
-
-
12. A kit useful for carrying out a method for predicting therapeutic success of a given mode of treatment in a patient having cancer or for adapting therapeutic regimen based on individualized risk assessment for a patient having cancer, comprising at least (a1) three primer pairs and/or (a2) three probes each having a sequence sufficiently complementary to the gene encoding VEGFC, ERBB3 and/or Her2/neu and/or (b) at least three antibodies directed against VEGFC, ERBB3 and Her2/neu.
- 13. A method for the treatment of a cancer associated with the recruitment of lymphatic vessels by expression of VEGFC comprising administering an effective amount of (a) an anti-VEGFC antibody, (b) an antisense nucleic acid or a ribozyme inhibiting the expression of the VEGFC encoding gene or (c) an inactive version of VEGFC as an antagonist.
Specification