METHODS OF MANUFACTURING DERIVATIVES OF BETA-HYDROXYCARBOXYLIC ACIDS
First Claim
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1. A method for preparing a β
- -hydroxycarboxylic acid ester comprising reacting a β
-hydroxycarboxylic acid, or salt thereof, with an alcohol in the presence of an esterification catalyst and the absence of solvent other than the alcohol under substantially anhydrous conditions at atmospheric pressure and a temperature less than reflux temperature to produce the ester.
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Abstract
Preparation of derivatives of β-hydroxycarboxylic acid, including β-hydroxycarboxylic acid esters, α,β-unsaturated carboxylic acid, esters of α,β-unsaturated carboxylic acid, and alkoxy derivatives.
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14 Claims
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1. A method for preparing a β
- -hydroxycarboxylic acid ester comprising reacting a β
-hydroxycarboxylic acid, or salt thereof, with an alcohol in the presence of an esterification catalyst and the absence of solvent other than the alcohol under substantially anhydrous conditions at atmospheric pressure and a temperature less than reflux temperature to produce the ester. - View Dependent Claims (2, 3, 4, 5, 6, 7)
- -hydroxycarboxylic acid ester comprising reacting a β
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8. A process for preparing a β
- -hydroxycarboxylic acid ester comprising;
(a) providing a fermentation broth comprising a β
-hydroxycarboxylic acid, or salt thereof, (b) forming a solution comprising the β
-hydroxycarboxylic acid, or salt thereof, from the fermentation broth; and
(c) reacting the β
-hydroxycarboxylic acid, or salt thereof, with an alcohol in the presence of an esterification catalyst and the absence of solvent other than the alcohol under substantially anhydrous conditions at atmospheric pressure and a temperature less than reflux temperature to produce the ester.
- -hydroxycarboxylic acid ester comprising;
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9. A method for preparing a β
- -hydroxycarboxylic acid ester comprising reacting a β
-hydroxycarboxylic acid with an alcohol containing between 1 and 7 carbon atoms, inclusive, in the presence of an esterification catalyst in a water-immiscible extractant to produce a reaction mixture comprising the ester and the extractant. - View Dependent Claims (10, 11, 12)
- -hydroxycarboxylic acid ester comprising reacting a β
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13. A method for preparing a β
- -hydroxycarboxylic acid ester comprising;
(a) providing a fermentation broth comprising a β
-hydroxycarboxylic acid, or salt thereof;
(b) treating the broth with a water-immiscible extractant to form an extract comprising the β
-hydroxycarboxylic acid and the extractant;
(c) combining the extract with an alcohol containing between 1 and 7 carbon atoms, inclusive, and an esterification catalyst; and
(d) reacting the β
-hydroxycarboxylic acid with the alcohol in the presence of the extractant and the catalyst to produce the ester.
- -hydroxycarboxylic acid ester comprising;
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14-49. -49. (canceled)
Specification