HEPATOCYTE LINEAGE CELLS
First Claim
1. A method of producing liver precursor cells, said method comprising the steps of obtaining a cell population comprising definitive endoderm cells and providing said cell population with a BMP family growth factor and an FGF family growth factor for a time sufficient to allow the differentiation of liver precursor cells from said definitive endoderm cells.
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Abstract
Disclosed herein are methods for producing liver precursor cells as well as hepatocyte cells form pluripotent and/or multipotent cells. Also disclosed herein are methods of enriching isolating and/or purifying liver precursor cells and/or hepatocyte cells. Further disclosed are compositions comprising cell cultures and cell populations that are enriched for liver precursor cells or hepatocyte cells.
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Citations
43 Claims
- 1. A method of producing liver precursor cells, said method comprising the steps of obtaining a cell population comprising definitive endoderm cells and providing said cell population with a BMP family growth factor and an FGF family growth factor for a time sufficient to allow the differentiation of liver precursor cells from said definitive endoderm cells.
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43-130. -130. (canceled)
Specification