BINDING DRUGS OF ABUSE
First Claim
1. A method of separating a target compound which is a drug of abuse or metabolite or analogue thereof from a mixture containing it by contacting the mixture with an adsorbent material that selectively binds the target compound, the adsorbent material comprising units derived from one or more fluorocarboxylic acids of formula A and/or B, or derivatives thereof:
- where R1 is selected from hydrogen, optionally-substituted alkyl or cycloalkyl, optionally-substituted aryl or heteroaryl, optionally-substituted amine, —
OR or —
SR where R is alkyl, cycloalkyl, aryl or heteroaryl and is optionally substituted;
R2 is selected from optionally-substituted alkyl or cycloalkyl, optionally-substituted aryl or heteroaryl, optionally-substituted amine, OR or SR where R is as defined above, or is a group containing a double or triple carbon-carbon bond; and
R3 is selected from optionally-substituted alkylene or cycloalkylene, oxygen or sulfur.
1 Assignment
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Accused Products
Abstract
Drugs of abuse (e.g. cocaine) and related substances are selectively bound by an adsorbent which comprises units derived from carboxylic acids of formula A or B: (A): R1R2C(CF3)—CO2H; (B): R3═C(CF3)—CO2H or derivatives thereof. The adsorbent may be a polymer, or a solid support onto which the carboxylic acid, derivative or polymer has been grafted. The preferenced acid is 2-trifluoromethyl acrylic acid. A drug can be selectively bound from a mixture, and recovered using an eluant comprising an organic acid.
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Citations
21 Claims
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1. A method of separating a target compound which is a drug of abuse or metabolite or analogue thereof from a mixture containing it by contacting the mixture with an adsorbent material that selectively binds the target compound, the adsorbent material comprising units derived from one or more fluorocarboxylic acids of formula A and/or B, or derivatives thereof:
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where R1 is selected from hydrogen, optionally-substituted alkyl or cycloalkyl, optionally-substituted aryl or heteroaryl, optionally-substituted amine, —
OR or —
SR where R is alkyl, cycloalkyl, aryl or heteroaryl and is optionally substituted;R2 is selected from optionally-substituted alkyl or cycloalkyl, optionally-substituted aryl or heteroaryl, optionally-substituted amine, OR or SR where R is as defined above, or is a group containing a double or triple carbon-carbon bond; and R3 is selected from optionally-substituted alkylene or cycloalkylene, oxygen or sulfur. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification