AEROSOL DELIVERY SYSTEMS AND METHODS

• US 20090301472A1
• Filed: 02/08/2008
• Published: 12/10/2009
• Est. Priority Date: 02/08/2007
• Status: Abandoned Application

• Current Assignee: Aerovectrx Corporation
• Original Assignee: Aerovectrx Corporation
• Inventors: Sawyer, Andrew S., Maciariello, James E., Zaugg, Doug E., Kim, Matthew H.J., Anderson, Stephanie R.S., Axelrod, Michael, Kapushion, Joseph L.
• Application Number:
  US12/069,430
• Publication Number:
  US 20090301472A1
• Time in Patent Office: Days
• US Class Current: 128/200.160
• CPC Class Codes: A61M 15/0085 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 15/0086 Inhalation chambers
• CPC Class Codes: A61M 16/06 Respiratory or anaesthetic masks
• CPC Class Codes: A61M 16/107 in the inspiratory path
• CPC Class Codes: A61M 2205/825 using mechanical generation of electricity, e.g. hand cranked generators

Abstract

Methods, systems and/or devices for generating and aerosol from one or more composition are provided herein.

Claims

1. A removable aerosolizing device for use with an aerosol delivery device, comprising:

a body having an inner surface and defining an exit port;

a biasable element having an inner surface and an opposed outer surface, wherein a portion of the respective inner surfaces of the body and the biasable element define an interior space; and

a source of agent configured to be selectively placed into fluid communication with the interior space, wherein the biasable element is configured to be biased in response to a force applied to the outer surface to expel agent in the interior space through the exit port.

2. The removable aerosolizing device of claim 1, further comprising a mesh element having an inner surface, wherein a portion of the respective inner surface of the mesh element defines a portion of the interior space, wherein the mesh element comprises one or more orifices, and wherein the mesh element is configured to be positioned therein at least a portion of the exit port such that the agent is expelled through the one or more orifices of the mesh element.

3. The removable aerosolizing device of claim 1, wherein the source of agent is positioned in a receptacle defined by the body.

4. The removable aerosolizing device of claim 3, wherein the source of agent is selectively movable therein the receptacle.

5. The removable aerosolizing device of claim 4, wherein the source of agent is constrained within the receptacle to prevent complete removal of the source of agent therefrom the receptacle.

6. The removable aerosolizing device of claim 3, wherein the receptacle comprises a piercing element for piercing at least a portion of the source of agent.

7. The removable aerosolizing device of claim 6, wherein the piercing element is configured to be in fluid communication with the interior space so that the agent can selectively flow out of the source of agent and into the interior space.

8. The removable aerosolizing device of claim 7, wherein the source of agent can be selectively moved onto the piercing element to affect the piercing.

9. The removable aerosolizing device of claim 8, wherein a portion of the exterior surface of the source of agent is configured to slideably move therein a pathway defined in a portion of the receptacle.

10. The removable aerosolizing device of claim 8, wherein the source of agent comprises a first surface that can be penetrated by the piercing element.

11. The removable aerosolizing device of claim 10, further comprising a spacer element positioned between the piercing element and the first surface of the source of agent, wherein the spacer element is removable to allow selective movement of the source of agent onto the piercing element to affect the piercing.

12. The removable aerosolizing device of claim 10, wherein the receptacle further comprising means for orienting the first surface of the source of agent relative to the piercing element as the source of agent is slideably moved onto the piercing element.

13. The removable aerosolizing element of claim 10, wherein the source of agent further comprises a second surface that can be selectively vented to facilitate flow of agent into the space.

14. The removable aerosolizing element of claim 13, wherein the second surface of the source of agent opposes the first surface of the source of agent.

15. An aerosol delivery device, comprising:

a housing;

a removable aerosolizing device that comprises a biasable portion and that defines an interior space, wherein the removable aerosolizing device is operatively attached thereto the housing;

an agent disposed within the interior space of the removable aerosolizing device;

an actuator disposed in the housing configured to be positioned in forced communication with a portion of the removable aerosolizing device, wherein the actuator comprises means for exerting a force on the biasable portion of the removable aerosolizing device to aerosolize agent in the interior space; and

a patient interface in fluid communication with the interior space that is configured to direct aerosolized agent to a subject.

16. The aerosol delivery device of claim 15, further comprising a spring mechanism disposed in the housing and selectively positioned to force the actuator into communication with at least a portion of the biasable portion of the aerosolizing device.

17. The aerosol delivery device of claim 16, further comprising an elastomeric element disposed in the housing and selectively positioned to force the actuator into communication with at least a portion of the biasable portion of the aerosolizing device.

18. The aerosol delivery device of claim, 15, wherein the actuator comprises an ultrasonic transducer and an ultrasonic horn.

19. The aerosol delivery device of claim 18, wherein the ultrasonic horn is convex in the direction of the biasable portion.

20. A removable aerosolizing device for use with an aerosol delivery device, comprising:

an aerosolizing element; and

a source of agent configured to be selectively placed into fluid communication with the aerosolizing element to deliver agent contained therein to the aerosolizing element, wherein the aerosolizing element is configured to be energized to generate an aerosol from the delivered agent for inhalational administration to a subject.

21. The removable aerosolizing device of claim 20, wherein the aerosolizing element comprises a biasable mesh element.

22. The removable aerosolizing device of claim 20, wherein the aerosolizing element comprises a biasable plate element.

23. The removable aerosolizing device of claim 20, wherein the aerosolizing element comprises a biasable plate element and a biasable mesh element.

24. The removable aerosolizing device of claim 23, wherein a portion of the biasable plate element operatively contacts a portion of the biasable mesh element.

25. The removable aerosolizing device of claim 24, wherein a space is defined between the biasable plate and the biasable mesh element.

26. The removable aerosolizing device of claim 25, wherein the source of agent is configured to be selectively placed into fluid communication with the space between the biasable plate and the biasable mesh element.

27. The removable aerosolizing device of claim 26, wherein the aerosolizing element is configured to generate an aerosol from agent delivered into the space between the biasable plate and the biasable mesh element.

28. The removable aerosolizing device of claim 20, further comprising a housing and wherein the aerosolizing element and source of agent are operatively attached to the housing.

29. The removable aerosolizing device of claim 28, wherein the source of agent is constrained by the housing to prevent complete removal of the source of agent therefrom the housing.

30. The removable aerosolizing device of claim 20, wherein the aerosolizing element is configured to be energized by ultrasonic energy.

31. An aerosol delivery device, comprising:

a housing;

a removable aerosolizing device comprising an aerosolizing element and a source of agent operatively attached thereto the housing, wherein the aerosolizing element is in fluid communication with the source of agent and is configured to be energized to aerosolize agent delivered therefrom the source of agent;

a patient interface in fluid communication with the aerosolizing element that is configured to direct aerosolized agent to a subject upon inhalation by the subject; and

feedback means for energizing the aerosolizing element to aerosolize the delivered agent.

32. The aerosol delivery device of claim 31, where in the feedback means comprises pressure detecting means for detecting a pressure change based on inhalation of the subject.

33. The aerosol delivery device of claim 32, wherein the pressure detecting means is located in at least one of the housing, removable aerosolizing device, and patient interface.

34. The aerosol delivery device of claim 33, wherein the feedback means further comprises a switchable actuator in operative communication with the pressure detecting means and configured to be switched between an active and deactivate state, wherein the active state energizes the aerosolizing element causing aerosolization of the agent.

35. The aerosol delivery device of claim 34, wherein the switching means is configured to activate the actuator when the detected pressure meets or is lower than a predetermined pressure value.

36. The aerosol delivery device of claim 34, wherein the switching means is configured to deactivate the actuator when the detected pressure exceeds than a predetermined pressure value.

37. A removable aerosolizing device for use with an aerosol delivery device, comprising:

a body having an inner surface and defining an exit port;

an aerosolizing element having an inner surface and an opposed outer surface, wherein a portion of the respective inner surfaces of the body and the aerosolizing element define an interior space; and

a source of agent configured to be selectively placed into fluid communication with the interior space, wherein the aerosolizing element is configured to be energized to expel agent in the interior space through the exit port.

38. The removable aerosolizing device of claim 37, wherein the aerosolizing element comprises a mesh portion having one or more orifices, and wherein the mesh element is configured to be positioned therein at least a portion of the exit port such that the agent is expelled through the one or more orifices of the mesh portion.

39. A removable aerosolizing device for use with an aerosol delivery device, comprising:

an aerosolizing element; and

a source of agent configured to be selectively placed into fluid communication with the aerosolizing element to deliver agent contained therein to the aerosolizing element, wherein the aerosolizing element is configured to be energized to generate an aerosol from the delivered agent.

40. The removable aerosolizing device of claim 39, wherein the aerosolizing element comprises a biasable mesh element.

41. The removable aerosolizing device of claim 39, wherein the aerosolizing element comprises a biasable plate element.

42. The removable aerosolizing device of claim 39, wherein the aerosolizing element comprises a biasable plate element and a biasable mesh element.

43. The removable aerosolizing device of claim 42, wherein a portion of the biasable plate element operatively contacts a portion of the biasable mesh element.

44. The removable aerosolizing device of claim 43, wherein a space is defined between the biasable plate and the biasable mesh element.

45. The removable aerosolizing device of claim 44, wherein the source of agent is configured to be selectively placed into fluid communication with the space between the biasable plate and the biasable mesh element.

46. The removable aerosolizing device of claim 45, wherein the aerosolizing element is configured to generate an aerosol from agent delivered into the space between the biasable plate and the biasable mesh element.

47. The removable aerosolizing device of claim 39, further comprising a housing and wherein the aerosolizing element and source of agent are operatively attached to the housing.

48. The removable aerosolizing device of claim 47, wherein the source of agent is constrained by the housing to prevent complete removal of the source of agent therefrom the housing.

49. The removable aerosolizing device of claim 39, wherein the aerosolizing element is configured to be energized by ultrasonic energy.