METHOD AND COMPOSITION FOR REMOVING UREMIC TOXINS IN DIALYSIS PROCESSES

• US 20090301958A1
• Filed: 08/13/2009
• Published: 12/10/2009
• Est. Priority Date: 11/13/2001
• Status: Active Grant

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Inventors: Martis, Leo, Donovan, Brian, Karoor, Sujatha, Sanders, Paul J., Mujais, Salim, Lu, Luis, Morti, Stavroula, Hai, Ton That, Soltys, Paul J., Tandon, Rahul, Katada, Mari
• Granted Patent: US 8,002,726 B2
• Time in Patent Office: Days
• US Class Current: 210/290
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/284 Continuous flow peritoneal dialysis [CFPD]
• CPC Class Codes: A61M 1/287 Dialysates therefor
• CPC Class Codes: B01D 15/00 Separating processes involving the treatment of liquids with solid sorbents using liquid sorbents B01D11/00; ion exchange processes or materials, sorbent materials in general B01J, e.g. sorbents for chromatography B01J20/281; for investigating or analysing materials G01N30/00; Apparatus therefor
• CPC Class Codes: B01J 20/0211 Compounds of Ti, Zr, Hf
• CPC Class Codes: B01J 20/0292 Phosphates of compounds other than those provided for in B01J20/048
• CPC Class Codes: B01J 20/06 comprising oxides or hydroxides of metals not provided for in group B01J20/04
• CPC Class Codes: B01J 20/20 comprising free carbon; comprising carbon obtained by carbonising processes
• CPC Class Codes: B01J 20/22 comprising organic material
• CPC Class Codes: B01J 20/28052 Several layers of identical or different sorbents stacked in a housing, e.g. in a column
• CPC Class Codes: B01J 39/10 Oxides or hydroxides
• CPC Class Codes: B01J 39/12 Compounds containing phosphorus
• CPC Class Codes: B01J 41/10 Inorganic material

Abstract

Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.

Claims

1. A device for removing uremic toxins in a dialysis procedure, the device comprising:

a body having an inlet and an outlet and defining an interior, the interior including a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon; and

the device being so constructed and arranged so that a fluid entering the device contacts the zirconium phosphate layer upon entering the device before contacting the urease layer.

2. The device of claim 1 wherein the fluid flows through the urease layer before entering the layer of zirconium oxide.

3. The device of claim 1 wherein the zirconium oxide has been modified by removing the nitrate ion.

4. The device of claim 1 wherein the zirconium oxide is in a bicarbonate form.

5. The device of claim 1 wherein the zirconium oxide is in a hydroxyl form.

6. The device of claim 1 wherein the carbon layer is located in juxtaposition to the outlet.

7. The device of claim 6 wherein the fluid flows through the layer of zirconium oxide before entering the carbon layer.

8. The device of claim 1 wherein the zirconium phosphate has a pH of approximately 2 to about 8.

9. The device of claim 1 wherein the zirconium oxide has a pH of approximately 6 to about 13.

10. The device of claim 1 further comprising a second separate layer comprising zirconium phosphate, the urease layer positioned between the layer comprising zirconium phosphate and the second separate layer comprising zirconium phosphate.

11. The device of claim 1 further comprising a second separate layer of zirconium oxide.

12. The device of claim 1 including an open header at each of the inlet and outlet end of the device.

13. The device of claim 1 including an opening for venting a gas to the atmosphere located at the outlet end.

14. A device for removing uremic toxins in a dialysis procedure, the device comprising:

a body having an inlet and an outlet and defining an interior, the interior including;

a modified urease layer comprising a modified urease selected from the group consisting of cross-linked enzyme crystals of urease, a blend of urease and zirconium oxide, alumina-stabilized urease and combinations thereof,

a layer comprising zirconium oxide,

a layer comprising zirconium phosphate, and

a layer comprising carbon; and

the device being so constructed and arranged so that a fluid entering the device contacts the zirconium phosphate layer upon entering the device before contacting the modified urease layer.

15. The device of claim 14 wherein a fluid entering the device contacts the zirconium phosphate layer upon entering the device before contacting the zirconium oxide layer.

16. The device of claim 14 wherein the body further comprises a rough interior surface, the rough interior surface preventing fluid flow along the interior surface.

17. The device of claim 14 further comprising a second separate layer comprising zirconium phosphate, the modified urease layer positioned between the layer comprising zirconium phosphate and the second separate layer comprising zirconium phosphate.