Method and a system for presenting sections of a histological specimen

• US 20090304244A1
• Filed: 04/10/2009
• Published: 12/10/2009
• Est. Priority Date: 06/06/2008
• Status: Abandoned Application

• Current Assignee: Applied Spectral Imaging Ltd.
• Original Assignee: Applied Spectral Imaging Ltd.
• Inventors: Klaiman, Eldad, Kolatt, Tsafrir
• Application Number:
  US12/385,532
• Publication Number:
  US 20090304244A1
• Time in Patent Office: Days
• US Class Current: 382/128
• CPC Class Codes: G01N 1/30 Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis

Abstract

A method for presenting at least one structure of a histological specimen. The method comprises providing a plurality of images of a plurality of sections of a single histological specimen having a plurality of structures, segmenting a plurality of segments of the plurality of structures in each the image, associating among respective the segments of a common structure of the plurality of structures, and presenting the association in relation to at least some of the plurality of images.

Claims

1. A method for presenting at least one structure of a histological specimen, the method comprising:

providing a plurality of images of a plurality of sections of a single histological specimen having a plurality of structures;

segmenting a plurality of segments of said plurality of structures in each said image;

associating among respective said segments of a common structure of said plurality of structures; and

presenting said association in relation to at least some of said plurality of images.

2. The method of claim 1, further comprising matching pixels of a segment of said plurality of segments with respective pixels of an associated segment of said plurality of segments.

3. The method of claim 1, wherein each said section is stained using at least one of a different staining procedure and a different staining agent.

4. The method of claim 1, wherein at least some of said associated segments are depicted in non-consecutive sections of said plurality of sections.

5. The method of claim 1, wherein said displaying further comprising aligning at least one of said plurality of images according to said association.

6. The method of claim 1, wherein said displaying further comprising reorienting at least one of said plurality of images according to said association.

7. The method of claim 1, wherein said associating comprises identifying a transformation between at least two of said plurality of segments.

8. The method of claim 1, wherein said associating comprises acquiring positional information of at least two of said associated segments, said presenting comprises adjusting said at least two of said associated segments according to said positional information.

9. The method of claim 1, further comprising verifying said associating by matching positional information of at least two of said associated segments.

10. The method of claim 1, wherein each said section is positioned on a single specimen slide.

11. The method of claim 1, wherein said associating comprises coloring said associated segments in a single color.

12. The method of claim 1, wherein said associating comprises labeling said associated segments with a single label.

13. The method of claim 1, wherein said associating comprises scoring the similarity between at least one pair of said plurality of segments and associating said segments according to said scoring.

14. The method of claim 13, wherein said associating comprises generating a probability matrix according to said scoring and associating said plurality of segments according to said probability matrix.

15. A system for presenting a histological specimen, said system comprising:

a receiving module configured for receiving a plurality of images of a plurality of sections of a single histological specimen having a plurality of structures;

a matching module configured for mapping segments of each said structure in each said section and associating among respective said segments of a common structure of said plurality of structures; and

an output module configured for allowing the presenting of an indication of said association in relation to at least one of said plurality of images.

16. The system of claim 15, further comprising a user interface configured for allowing a user to select at least one of said plurality of segments, said matching module being configured for performing said mapping according to said selection, said associating comprising associating an area respective to said selected area.

17. The system of claim 15, wherein said matching module is configured for aligning said plurality of images according to said associating, said indication comprising said aligned images, said presentation unit being configured for displaying said aligned images to a user.

18. An apparatus for allowing the presentation of a single histological specimen, said apparatus comprising:

a receiving module configured for receiving a plurality of images each of a different section of a single histological specimen;

a user interface for allowing a user to select a first area in a first location in one of said plurality of images;

a matching module configured for identifying a second area in a second location in another of said plurality of images, said second location being respective to said first location; and

an output module configured for allowing the presenting of an association between said first and second areas according to said identification.

19. The apparatus of claim 18, wherein said matching module is configured for identifying said second area by segmenting a plurality of segments of a plurality of structures of said single histological specimen in each said image, and associating among segments of each said structure.

20. The apparatus of claim 18, wherein said receiving module is configured to receive said plurality of images from a microscope camera.

21. The apparatus of claim 18, wherein said output module is configured for allowing said presenting automatically in response to said user selection of said first area.