Super fast-acting insulin compositions
First Claim
Patent Images
1. A super fast-acting insulin composition, comprising:
- a therapeutically effective amount for controlling blood glucose levels of a fast-acting insulin; and
an amount of a hyaluronan degrading enzyme sufficient to render the composition a super fast-acting insulin composition.
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Accused Products
Abstract
Provided are combinations, compositions and kits containing an fast-acting insulin composition and a hyaluronan degrading enzyme composition formulated for parenteral administration. Such products can be used in methods of treating insulin-treatable diseases or conditions. Also provided are methods for administration of a fast-acting insulin and a hyaluronan degrading enzyme.
118 Citations
140 Claims
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1. A super fast-acting insulin composition, comprising:
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a therapeutically effective amount for controlling blood glucose levels of a fast-acting insulin; and an amount of a hyaluronan degrading enzyme sufficient to render the composition a super fast-acting insulin composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 85, 86, 87, 88, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112)
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44. A closed loop system for controlling blood glucose levels in a subject, comprising:
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a fast-acting insulin; and
a hyaluronan degrading enzyme;
whereinthe fast-acting insulin and the hyaluronan degrading enzyme are in the same or different reservoirs. - View Dependent Claims (45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65)
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66. A method for making a super fast-acting insulin composition, comprising:
selecting a fast-acting insulin and combining it with a sufficient amount of hyaluronan degrading enzyme to render the composition a super fast-acting insulin composition. - View Dependent Claims (67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84)
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89. A method, comprising:
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instructing a patient to administer a fast-acting insulin composition less than or about 20, 10, or 5 minutes prior to a meal, to less than or about 30 minutes after a meal, wherein; the fast-acting insulin is co-administered with a sufficient amount of hyaluronan-degrading enzyme to render the fast-acting insulin composition a super fast acting composition. - View Dependent Claims (90, 91, 92, 93)
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113. A combination, comprising:
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a first composition containing from or from about 10 U to or to about 500 U insulin; and a second composition containing sufficient amount of hyaluronan degrading enzyme that, when administered with the insulin, renders the fast-acting insulin a superfast acting insulin;
whereinthe sufficient amount of hyaluronan degrading enzyme is functionally equivalent to least or about 1 U/mL, 2 U/mL, 3 U/mL, 4 U/mL, 5 U/mL, 6 U/mL, 7 U/mL, 8 U/mL, 9 U/mL, 10 U/mL, 15 U/mL, 20 U/mL, 25 U/mL, 30 U/mL or 35 Units hyaluronidase activity/mL. - View Dependent Claims (114, 115, 116, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 139)
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117. A combination, comprising:
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a first composition containing a hyaluronan degrading enzyme; and a second composition containing a fast-acting insulin, wherein; the compositions are formulated for parenteral administration; and the amount of hyaluronan degrading enzyme is sufficient if mixed with the second composition to render the resulting composition a super fast-acting insulin composition;
orthe amount of the hyaluronan degrading enzyme is sufficient if administered prior to the administration of the first composition to render the fast-acting insulin composition a super fast-acting insulin composition. - View Dependent Claims (118, 119, 138, 140)
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Specification