Microarray Microcard
First Claim
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1. A fluid processing device comprising:
- a substrate comprising a surface; and
at least one fluid processing pathway at least partially formed in or on the surface, the fluid processing pathway comprising,a channel comprising a first end and a second end,a reaction region in fluid communication with the first end,a deformable valve adapted to open and provide fluid communication through the channel,a fluid retainment region in fluid communication with the second end, anda microarray disposed in the fluid retainment region, the microarray comprising a plurality of binding sites, each binding site comprising an immobilized moiety,wherein at least two of the binding moieties are different from one another.
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Abstract
A fluid processing device is provided that comprises a substrate including a surface and a fluid processing pathway at least partially formed in or on the surface. The fluid processing pathway can comprise a channel, a reaction region in fluid communication with the channel, a microarray in fluid communication with the channel, and optionally a deformable valve. The microarray can comprise binding and/or detection sites, and each site can comprise a binding moiety. A method and a system using the fluid processing device, are also provided.
27 Citations
20 Claims
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1. A fluid processing device comprising:
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a substrate comprising a surface; and at least one fluid processing pathway at least partially formed in or on the surface, the fluid processing pathway comprising, a channel comprising a first end and a second end, a reaction region in fluid communication with the first end, a deformable valve adapted to open and provide fluid communication through the channel, a fluid retainment region in fluid communication with the second end, and a microarray disposed in the fluid retainment region, the microarray comprising a plurality of binding sites, each binding site comprising an immobilized moiety, wherein at least two of the binding moieties are different from one another. - View Dependent Claims (2, 4, 5, 6, 7)
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3. The fluid processing device of claim 3, wherein the at least one reagent comprises a reagent for a nucleic acid amplification reaction.
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8. A method comprising:
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loading a sample into a reaction region of a fluid processing device; reacting the sample in the reaction region to form a reaction product; opening a deformable valve along a fluid communication leading away from the reaction region; moving the reaction product from the reaction region through the fluid communication and into a hybridization array; and reacting the reaction product with binding moieties of the microarray. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15)
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16. A system, comprising:
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a platen; a fluid processing device holder disposed in the platen and adapted to hold at least one fluid processing device, comprising, a substrate comprising a surface; and at least one fluid processing pathway at least partially formed in or on the surface, the fluid processing pathway comprising; a channel comprising a first end and a second end, a reaction region in fluid communication with the first end, a deformable valve adapted to open and provide fluid communication through the channel, a fluid retainment region in fluid communication with the second end, and a microarray disposed in the fluid retainment region, the microarray comprising a plurality of binding sites, each binding site comprising an binding moiety, wherein at least two of the binding moieties are different from one another; and a detector adapted to detect a detectable characteristic from at least one of the binding sites. - View Dependent Claims (17, 18, 20)
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19. The system of claim 41, further comprising an excitation source adapted to emit an excitation beam directed to at least one of the binding sites.
Specification