DNA encoding OSK1 toxin peptide analogs and vectors and cells for combinant expression
First Claim
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1. A DNA encoding an OSK1 peptide analog comprising an amino acid sequence of the formula:
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Abstract
Disclosed is a composition of matter comprising an OSK1 peptide analog, and in some embodiments, a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises the composition and a pharmaceutically acceptable carrier. Also disclosed are DNAs encoding the inventive composition of matter, an expression vector comprising the DNA, and host cells comprising the expression vector. Methods of treating an autoimmune disorder and of preventing or mitigating a relapse of a symptom of multiple sclerosis are also disclosed.
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15 Claims
- 1. A DNA encoding an OSK1 peptide analog comprising an amino acid sequence of the formula:
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10. A DNA encoding an OSK1 peptide analog that comprises an amino acid sequence selected from SEQ ID NOS:
- 1391 through 4912, 4916, 4920 through 5006, 5009, 5010, and 5012 through 5015 as set forth in Tables 7A-J, or a pharmaceutically acceptable salt of the OSK1 peptide analog.
Specification