IMPLANTABLE NEURAL PROSTHETIC DEVICE AND METHODS OF USE

• US 20090306491A1
• Filed: 05/29/2009
• Published: 12/10/2009
• Est. Priority Date: 05/30/2008
• Status: Abandoned Application

• Current Assignee: Central Nervous System, Limited
• Original Assignee: Central Nervous System, Limited
• Inventors: Haggers, Marcus
• Application Number:
  US12/475,428
• Publication Number:
  US 20090306491A1
• Time in Patent Office: Days
• US Class Current: 600/373
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/4041 Evaluating nerves condition
• CPC Class Codes: A61B 5/407 Evaluating the spinal cord A61B5/4896 takes precedence
• CPC Class Codes: A61B 5/4076 Diagnosing or monitoring particular conditions of the nervous system A61B5/4821, A61B5/4824 take precedence
• CPC Class Codes: A61B 5/4082 Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
• CPC Class Codes: A61B 5/4519 Muscles A61B5/389, A61B5/224 take precedence
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/37229 Shape or location of the implanted or external antenna
• CPC Class Codes: A61N 1/37288 Communication to several implantable medical devices within one patient

Abstract

Neural stimulation devices are described that detect the neural activity from the spinal cord in a semi-invasive manner, where the device comprises at least one antenna array comprising an antenna. The antenna of the array is in electrical communication with the spinal cord of the patient. A device comprising more than one antenna array can be used to detect the neural signal strength, as well as the velocity and directionality of the signal.

Claims

1. A neural prosthetic device comprising:

at least one antenna array comprising an antenna adaptable to be in electrical communication with a neural tissue of a subject.

2. The device of claim 1 wherein the neural tissue comprises a spinal cord.

3. The device of claim 1 comprising at least two antennae.

4. The device of claim 1 wherein the device is adaptable to partially encircle a spinal cord.

5. The device of claim 1 wherein the device is adaptable to entirely encircle a spinal cord.

6. The device of claim 1 wherein the device is adaptable to detect neural activity from a single neuron.

7. The device of claim 1 wherein the device is adaptable to detect neural activity from a population of neurons.

8. The device of claim 7 wherein the population of neurons comprises a regional population of neurons.

9. The device of claim 1 wherein the device is adaptable to be implanted in tissue adjacent to the spinal cord.

10. The device of claim 9 wherein the tissue comprises one or more of bone tissue, cartilage, or epidural fat.

11. The device of claim 1 wherein the device is adaptable to detect the velocity of a neural signal.

12. The device of claim 1 wherein the device is adaptable to stimulate, modulate or suppress neural activity in the neural tissue.

13. The device of claim 1 further comprising a shielding system.

14. The device of claim 1 further comprising:

(a) a first bank of one or more antenna arrays in electrical communication with a first region of a spinal cord; and

(b) a second bank of one or more antenna arrays in electrical communication with a second region of the spinal cord,

the first bank vertically displaced in relation to the second bank.

18. The device of claim 1 wherein the device is adaptable to communicate with one or more of a secondary implant device, a neuromuscular stimulation implant, an exoskeleton system, a powered prosthetic limb, and an external device.

19. The device of claim 18 wherein the external device is an external communication device, an actuator, a prosthetic device, a computer system, a suitable device to treat a neurological condition, a weapon, a robot, a television (TV), a radio, a mechanical bed system, a stove, an oven, a wheelchair, a home appliance, a vehicle, a telerobot, an external voice synthesizer, or an external microchip.

15-17. -17. (canceled)

20-23. -23. (canceled)

24. A method for detecting neural activity comprising the steps of:

(a) implanting an antenna array into the tissue adjacent to a spinal cord of a subject in need thereof;

(b) detecting the neural activity from the spinal cord using the antenna array; and

(c) analyzing the detected neural activity.

25. The method of claim 24 further comprising the step of stimulating, modulating or suppressing the spinal cord in response to the detected neural activity.

26. The method of claims 24 wherein the subject has a condition characterized by pain or loss of motion control.

27. The method of claim 26 wherein the condition comprises one or more of Parkinson'"'"'s disease, essential tremor, alcoholism, liver disease, kidney disease, multiple sclerosis, stroke, hypoglycemia, brain tumor, hyperthyroidism, Wilson'"'"'s disease, Friedrich'"'"'s ataxia, tertiary syphilis, a seizure disorder, cerebral palsy and Huntington'"'"'s disease.

28. The method of claim 26 wherein the condition comprises one or more of a urological condition, peripheral neuropathy, impaired gait after stroke, spinal cord injury (SCI), impaired hand and arm function after SCI, head injury, concussion, urinary incontinence, fecal incontinence, micturation/retention, sexual dysfunction, defecation/constipation, pelvic floor muscle activity, pelvic pain, visual impairment, sensorineural abnormalities and motorneural abnormalities.

29. The method of claim 26 wherein the subject is being treated with one or more additional therapies to treat the condition characterized by pain or loss of motion control.

30. The method of claim 29 wherein the condition is Parkinson'"'"'s disease and the one or more additional therapies comprise one or more of levodopa, carbidopa, anticholinergics, bromocriptine, pramipexole, ropinirole, amantadine, rasagiline, or DBS.

31. The method of claim 29 wherein the condition is essential tremor and the one or more additional therapies comprise one or more of beta blockers, propranolol, atenolol, metoprolol nadolo, anticonvulsant drugs, primidone, gabapentin, topiramate, tranquilizers, diazepam, alprazolam, physical therapy, 1-octanol, and botulinum toxin.

32. The method of claim 29 wherein the condition is cerebral palsy and the one or more additional therapies comprise one or more of physical therapy, occupational therapy, speech therapy, seizure medication, muscle relaxants, pain medication, surgery to correct anatomical abnormalities or release tight muscles, orthotic devices, braces, wheelchairs, rolling walkers, communication aids, or computers with attached voice synthesizers.

33. The method of claim 29 wherein the condition is Huntington'"'"'s disease and the one or more additional therapies comprise one or more of tetrabenazine, clonazepam, haloperidol, clozapine, fluoxetine, sertraline, nortriptyline, lithium, speech therapy, physical therapy, and occupational therapy.

34. The method of claim 29 wherein the condition is stroke and the one or more additional therapies comprise one or more of antithrombotics, antiplatelet agents, anticoagulants, thrombolytics, aspirin, warfarin, heparin, tissue plasminogen activator, arotid endarterectomy, angioplasty, stents, aneurysm clipping, arteriovenous malformation (AVM) removal, and rehabilitation.