ELECTRONICALLY CONTROLLED CAPSULE

• US 20090306633A1
• Filed: 01/16/2006
• Published: 12/10/2009
• Est. Priority Date: 01/18/2005
• Status: Abandoned Application

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Naamat, Judy R., Trovato, Karen I.
• Application Number:
  US11/814,248
• Publication Number:
  US 20090306633A1
• Time in Patent Office: Days
• US Class Current: 604/891.100
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging
• CPC Class Codes: A61B 5/036 by means introduced into body tracts A61B5/032 and A61B5/035 take precedence
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 2205/0244 Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
• CPC Class Codes: A61M 2205/0294 Piezoelectric materials
• CPC Class Codes: A61M 2205/3507 with implanted devices, e.g. external control
• CPC Class Codes: A61M 2205/3576 with non implanted data transmission devices, e.g. using external transmitter or receiver
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2210/1042 Alimentary tract A61M2210/0618 takes precedence
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

An electronically controlled capsule or medicament delivery system (900) is provided. Disposed within a housing (102) of the system (900) configured for internal placement within a patient is a reservoir (960) for storing medicament. The reservoir (960) communicates with at least one respective aperture (970) of the housing (102). A pressure mechanism (962) is provided for displacing medicament stored within the reservoir (960) for causing the medicament to exit the housing (102) through the at least one respective aperture (970). At least one a closure member (966) is provided. Respective closure members (966) are in fluid communication with an associated aperture. The respective closure members (966) are actuatable between a closed state for substantially blocking flow of the medicament through the respective closure member (966) and an open state for permitting flow of the medicament through the respective closure member (966) for dispensing of the medicament. Control circuitry (906) is provided for controlling at least one of the pressure mechanism (962) and actuation of the respective closure members (966).

Claims

1. A medicament delivery system (900) for dispensing a medicament from within a patient, said system (900) comprising:

a housing (102) internally placed within a patient having at least one aperture;

a reservoir (960) disposed within said housing (102) for storing said medicament, said reservoir (960) communicating with at least one respective aperture of the at least one aperture (970) in the housing (102);

a pressure mechanism (962) for displacing medicament stored within the reservoir (960) for causing the medicament to exit the housing (102) through the at least one respective aperture;

at least one a closure member (966), a respective closure member of the at least one closure member (966) in fluid communication with an associated aperture of the at least one respective aperture, the respective closure member actuatable between a closed state for substantially blocking flow of the medicament through the respective closure member and an open state for permitting flow of the medicament through the respective closure member for dispensing of the medicament; and

control circuitry (906) for controlling at least one of said pressure mechanism (962) and actuation of said respective closure members of the at least one closure member (966).

2. The delivery system (900) in accordance with claim 1, wherein the housing (102) of the delivery system (900) is ingestible for dispensing the medicament into the alimentary tract of the patient.

3. The delivery system (900) in accordance with claim 1, wherein the housing (102) of the delivery system (900) is configured for implanting in the anatomy of the patient.

4. The delivery system (900) in accordance with claim 1, wherein the control circuitry (906) controls the at least one of said pressure mechanism (962) and said respective closure members (966) for repeated intermittent dispensing of the medicament.

5. The delivery system (900) in accordance with claim 1, wherein the control circuitry (906) controls the pressure mechanism (962) for controlling characteristics of the dispensing selected from the group consisting of a rate of dispensing the medicament, a force at which the medicament is dispensed, duration of dispensing the medicament and timing of dispensing the medicament.

6. The delivery system (900) in accordance with claim 1, wherein the control circuitry (906) controls at least one of an amount of displacement of the medicament and a size of an opening of the respective closure members (966) when actuated to an open state.

7. The delivery system (900) in accordance with claim 1, wherein the respective closure member includes a MEMS microvalve and an associated actuator.

8. The delivery system (900) in accordance with claim 1, wherein the respective closure member includes a hatch and a MEMS motor for opening and closing the hatch.

9. The delivery system (900) in accordance with claim 1, where in the respective closure member includes an artificial muscle including a polymer which selectably contracts and expands in response to an electrical stimulus for facilitating achievement of the open and closed state of the respective closure member.

10. The delivery system (900) in accordance with claim 1, wherein the pressure mechanism (962) includes an artificial muscle including a polymer which selectably contracts and expands in response to an electrical stimulus for facilitating displacing of the medicament within the reservoir.

11. The delivery system (900) in accordance with claim 1, wherein the pressure mechanism (962) comprises:

a controlled osmotic pressure mechanism (1002) having an outer osmotic membrane, wherein the osmotic pressure mechanism (1002) is responsive to exposure of the osmotic membrane to fluid which enters the housing (102) for displacing the medicament; and

a second closure member (1012) disposed on the housing (102) in fluid communication with an aperture (1010) of the at least one aperture (970), the second closure member (1012) actuatable between a closed state for substantially blocking fluid exterior to the housing (102) from flowing through the second closure member (1012) and entering the housing (102) and an open state for permitting fluid to flow through the second closure member 91012) and enter the housing (102);

wherein the control circuitry (906) controls actuation of the second closure member (1012) for controlling displacement of the medicament.

12. The delivery system (900) in accordance with claim 1, wherein the respective closure members (966) are directed in different directions for facilitating dispensing of the medicament in multiple directions.

13. The delivery system (900) in accordance with claim 1, wherein respective closure members (966) are independently controllable by the control circuitry (906).

14. The delivery system (900) in accordance with claim 1, wherein the system further comprises:

a second reservoir (960) disposed within said housing (102) for storing additional medicament, said second reservoir (960) communicating with at least one respective aperture of the at least one aperture (970) in the housing (102);

a second pressure mechanism (962) for displacing the medicament stored within the second reservoir (960) for causing the medicament to exit the housing through the at least one respective aperture in communication with the second reservoir (960); and

at least one second closure member (966) a respective second closure member of the at least one second closure member (966) in fluid communication with an associated aperture of the at least one respective aperture (970) in communication with the second reservoir (960), the respective second closure member actuatable between a closed state for substantially blocking flow of the medicament through the respective second closure member and an open state for permitting flow of the medicament through the respective second closure member for dispensing of the medicament, wherein the respective second closure member is actuatable from the open state to the closed state;

wherein the control circuitry (906) further controls at least one of said second pressure mechanism (962) and said respective second closure members of said at least one second closure member (966).

15. The delivery system (900) in accordance with claim 14, wherein said reservoir (960), said pressure mechanism (962) and at least one closure member (966) are disposed in a first module (1202, 1302) and said second reservoir (1204, 1304), said second pressure mechanism (962) and at least one second closure member (966) are disposed in the second module (1204, 1304);

wherein said system (900) is assembled by assembling said first and second modules (1202, 1302;

1204, 1304) within the housing (102) so that said first and second modules (1202, 1302;

1204, 1304) are disposed within the housing (102).

16. The delivery system (900) in accordance with claim 15, wherein said control circuitry (906) includes a first control circuitry included in the first module (1202, 1302) for controlling at least one of said pressure mechanism (962) and said respective closure members of said first module (1202, 1302), and a second control circuitry included in the second module (1204, 1304) for controlling at least one of said second pressure mechanism (962) and said respective second closure members (966) of said second module (1204, 1304).

17. The delivery system (900) in accordance with claim 15, wherein said first and second modules (1202, 1302;

1204, 1304) respectively include communication circuitry for facilitating wireless communication between the first and second modules (1202, 1302;

1204, 1304).

18. The delivery system (900) in accordance with claim 15, wherein the reservoir (960) and the second reservoir (960) are filled with the respective medicaments, after which the system is assembled.

19. The delivery system (900) in accordance with claim 1, wherein the control circuitry (906) includes at least one processor that is programmable by processing circuitry exterior from the patient.

20. The delivery system (900) in accordance with claim 1, further comprising communication circuitry for communicating wirelessly with a remote device.

21. The delivery system (900) in accordance with claim 20, wherein the communication circuitry includes an ultrasound transducer element (510a) for transmitting and receiving ultrasound signals.

22. The delivery system (900) in accordance with claim 1, wherein an open end of the reservoir (960) is coincident with the aperture associated with the respective closure member, and wherein the respective closure member provides selectable closure thereto.

23. An internal medical capsule system (900) comprising:

a housing (102) for internal placement within a patient;

control circuitry (906);

a medical system disposed in the housing performing a medical function controllable by the control circuitry (906); and

an ultrasound transducer element (510a) disposed in the housing (102) for receiving and transmitting ultrasound signals between at least one of the medical system (900) and the control circuitry (906) and another device external to the housing.

24. The internal medical capsule system (900) according to claim 23, wherein the housing (906), medical system and ultrasound transducer element (510a) are collectively configured as one of a capsule and a medical implant device.

25. The internal medical capsule system (900) according to claim 23, wherein the medical system includes at least one system selected from the group consisting of a medicament dispensing system, an imaging system, a sensor system having at least one sensor, a communication system for communicating with an external processor, a sampling system for extracting biological samples, a medical diagnostic system, and a medical therapeutic system.

26. The internal medical capsule system (900) according to claim 23, wherein the ultrasound transducer element (510a) is configured for receiving and transmitting signals with at least one of an ultrasound transducer element disposed in the housing of a different medical internal capsule system, an ultrasound transducer element located external to the internal medical capsule system (900), and an ultrasound transducer element located external to the patient.

27. The internal medical capsule system (900) according to claim 23, wherein the ultrasound transducer element (510a) includes a piezoelectric element.

28. A method for delivering a medicament within the alimentary tract of a patient, comprising the step of:

providing for dispensing a medicament from an ingested capsule (900) traversing the alimentary tract of a patient to ambient surroundings of the capsule (900) comprising the steps of;

providing for storing said medicament within said ingested capsule (900);

providing for displacing said stored medicament for causing the medicament to flow from storage to the ambient surroundings of the capsule (900);

providing for blocking selectively flow of the medicament to the ambient surroundings; and

providing for controlling at least one of the displacing and the blocking for intermittently dispensing the medicament.

29. The method according to claim 28;

wherein the medicament includes at least one medicament selected from the group consisting of a contrast agent and a medical marker; and

wherein the providing for controlling is performed in accordance with at least one predetermined condition selected from the group consisting of a time condition, receipt of a command from an external processor, a sensed condition and sensing of medicament deposited by another capsule.

30. The method according to claim 29, wherein the time condition includes regular time intervals.

31. The method according to claim 30, further comprising the steps of:

providing for traversing the alimentary tract with a second capsule having a camera on board for acquiring images during the traversal;

providing for traversing the alimentary tract with the capsule (900) for depositing the medicament at the regular time intervals for depositing a series of marks along the alimentary tract, wherein the second capsule traverses a reference location at time=0 and the capsule (900) traverses the reference location at time=“

s”

;

providing for determining from the images acquired by the camera an area to be targeted for a subsequent procedure;

providing for determining “

t”

, where at time=“

t”

the targeted area was traversed by the second capsule;

providing for determining the location relative to a specific mark of the series of marks which was traversed by the capsule (900) at time=“

t+s”

; and

providing for traversing the alimentary tract with a third capsule for performing a procedure directed at the targeted area comprising the steps of;

providing for recognizing deposited marks of the series of marks traversed by the third capsule;

providing for determining when the third capsule traverses the location relative to the specific mark; and

providing for performing the procedure by the third capsule to tissue at the determined location.

32. The method according to claim 29, wherein the providing for dispensing the dispensed medicament step provides for deposition of the medicament along the alimentary tract at multiple discrete locations;

the method further comprising the step of performing at least one function selected from the group of functions consisting of using the depositions as fiducial markings for a subsequent medical therapeutic procedure, using the depositions as fiducial markings for a subsequent medical diagnostic procedure, using the depositions as fiducial markings for an imaging procedure, using the depositions as fiducial markings for studying peristaltic movement of the alimentary tract, using the depositions as fiducial markings for registering between 3D images acquired at different times, using the depositions as fiducial markings for registering between 3D images acquired using at least two different modalities and registering between 3D images acquired at different times using at least two different modalities.

33. The method according to claim 28, wherein the medicament includes a first contrast agent having a first color and further comprising the step of:

providing for dispensing a second medicament including a second contrast agent having a second color different from the first color from a second ingested capsule (900) traversing the alimentary tract of the patient to ambient surroundings of the second capsule (900) comprising the steps of;

providing for storing said medicament within said second ingested capsule (900);

providing for displacing said stored medicament for causing the medicament to flow from storage to the ambient surroundings of the second ingested capsule (900);

providing for blocking selectively flow of the medicament to the ambient surroundings; and

providing for controlling at least one of the displacing and the blocking for intermittently dispensing the medicament;

wherein the second ingested capsule (900) is one of the same as the first ingested capsule (900) or is ingested subsequently to ingestion of the ingested capsule (900) storing the medicament including the first contrast agent.

34. The method according to claim 28, wherein the controlling step includes controlling an amount of medicament dispensed and a force at which the medicament is dispensed.

35. The method according to claim 28, the method further comprising the step of providing for sensing PH levels in the ambient surroundings of the capsule (900), and wherein the providing for controlling step includes controlling in accordance with sensed PH levels indicating that the capsule (900) is located in one of the large intestine or the far end of the small intestine.

36. A treatment system for administering at least two medicaments comprising:

a first and second medicament delivery system (900) for dispensing a medicament within a patient, each of said first and second systems (100) comprising;

a housing (102) internally placed within a patient having at least one aperture (970);

a reservoir (960) disposed within said housing (102) for storing said medicament, said reservoir (960) communicating with at least one respective aperture of the at least one aperture (970) in the housing (102);

a pressure mechanism (962) for displacing medicament stored within the reservoir (960) for causing the medicament to exit the housing (102) through the at least one respective aperture (970);

at least one a closure member (966), a respective closure member of the at least one closure member (966) in fluid communication with an associated aperture of the at least one respective aperture (970), the respective closure member actuatable between a closed state for substantially blocking flow of the medicament through the respective closure member and an open state for permitting flow of the medicament through the respective closure member (966) for dispensing of the medicament;

control circuitry (906) for controlling at least one of said pressure mechanism (962) and actuation of said respective closure members of the at least one closure member (966); and

signal circuitry (502, 504, 510a) for providing a signal from one of the first and second medicament delivery systems (900) to the other of the first and second medicament delivery systems (900).

37. The treatment system according to claim 36, wherein the control circuitry (906) of at least one of the first and second medicament delivery systems (900) controls in accordance with a signal provided from the other of the first and second medicament delivery systems (900).

38. The treatment system according to claim 36, wherein the signal circuitry (502, 504, 510a) of one of the first and second medicament delivery systems (900) includes an ultrasound transducer element (510a) for transmitting ultrasound signals and the signal circuitry (502, 504, 510a) of the other of the first and second medicament delivery systems includes an ultrasound transducer element (510a) for receiving the transmitted ultrasound signals.

39. The treatment system according to claim 36, wherein the signal circuitry (502, 504, 510a) of one of the first and second medicament delivery systems includes an RF antenna (502) for transmitting RF signals and the signal circuitry (502, 504, 510a) of the other of the first and second medicament delivery systems (900) includes an RF antenna (502) for receiving the transmitted RF signals.

40. An internal medical capsule system (900) comprising:

a housing (102) for ingestion by a patient and traversal of the patient'"'"'s alimentary tract;

a light source assembly (1504) disposed in the housing (102) for illuminating the environment of the housing (102);

a photo detector assembly (1506) disposed in the housing (102) for sensing incident light reflected from walls of the alimentary tract and generating a corresponding signal; and

control circuitry (906) for processing reflecting properties of the incident light including generating a first control signal when the corresponding signal indicates that the incident light was reflected from a medical marker deposited by a preceding capsule, and generating a second control signal when the corresponding signal indicates that the incident light was reflected from tissue of the alimentary tract unmarked by a deposited medical marker.

41. The internal medical capsule system (900) according to claim 40, wherein the photo detector assembly (1506) includes one or two rows of photo detectors.

42. The internal medical capsule system (900) according to claim 40, wherein the light source assembly (1504) includes a laser light source.

43. The internal medical capsule system (900) according to claim 42, wherein the system (900) further comprises a deflection assembly disposed in the housing (102) for deflecting a laser light generated by the laser light source for scanning with the laser light.

44. A modular component (1202, 1204, 1302, 1304, 1306) of an electrical internal medicament dispensing system (1200, 1300) comprising:

a reservoir (960) for holding a medicament; and

at least one connector for plugging the modular component into the medicament dispensing system (1200, 1300) for assembling the medicament dispensing system (1200, 1300);

wherein when assembled, medicament from the reservoir (960) is controllably dispensed from the medicament dispensing system (1200, 1300) for dispensing the medicament within a patient.

45. The modular component according to claim 44, further comprising at least one control mechanism for controlling dispensing of the medicament.

46. A medicament dispensing system (1200, 1300) comprising:

a housing (102);

at least one modular component (1202, 1302;

1204, 1304) comprising;

a reservoir (960) for holding a medicament; and

at least one connector for plugging the at least one modular component (1202, 1302;

1204, 1304) into the medicament dispensing system (1200, 1300) for assembling the medicament dispensing system (1200, 1300);

at least one control mechanism for controlling dispensing of the medicament from the reservoir (960) of respective modular components of the at least one modular component (1202, 1302;

1204, 1304) through the housing (102); and

control circuitry (906) for controlling actuation of the at least one control mechanism;

wherein when assembled the at least one modular component is disposed within the housing and medicament from the respective reservoirs (960) is controllably dispensed through the housing (102) of the medicament dispensing system for dispensing the medicament within a patient.

47. The medicament dispensing system according to claim 46, wherein the at least one control mechanism includes at least one control mechanism included in respective modular components of the at least one modular component (1202, 1302;

1204, 1304).