ACCELEROMETER-BASED MONITORING OF THE FREQUENCY DYNAMICS OF THE ISOVOLUMIC CONTRACTION PHASE AND PATHOLOGIC CARDIAC VIBRATIONS
First Claim
1. A system for monitoring cardiac function, comprising:
- a catheter component, the catheter component including;
a portion for insertion within or on a patient'"'"'s heart, the insertion portion including an acceleration sensor;
an external portion including a connector to carry signals from the acceleration sensor;
a signal receiving and analysis component, the signal receiving and analysis component including;
a frequency analyzer to analyze the frequency dynamics of at least the S1 heart sound as measured by the acceleration sensor.
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Accused Products
Abstract
Methods and systems are disclosed that characterize cardiac function using an acceleration sensor to acquire and analyze the frequency dynamics associated with the isovolumic contraction phase (“ICP”). This information can be used to characterize heart function; optimize therapy for cardiomyopathy, including CRT therapy (including pacing intervals and required pharmacologic therapy); and to optimize CCM therapy. In addition, this information can be used to identify target pacing regions for CRT lead placement. Further, analyzing the frequency dynamics can be used to characterize pathologic heart vibrational motion, such as mitral regurgitation and the third or fourth heart sound, and the response of this motion to therapy for cardiomyopathy.
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Citations
42 Claims
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1. A system for monitoring cardiac function, comprising:
a catheter component, the catheter component including; a portion for insertion within or on a patient'"'"'s heart, the insertion portion including an acceleration sensor; an external portion including a connector to carry signals from the acceleration sensor; a signal receiving and analysis component, the signal receiving and analysis component including; a frequency analyzer to analyze the frequency dynamics of at least the S1 heart sound as measured by the acceleration sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for monitoring cardiac function, comprising:
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inserting a catheter into a patient, a distal tip of the catheter including a section that resides within or on a patient'"'"'s heart, the section including an acceleration sensor; receiving signals from the acceleration sensor at a signal receiving and analysis component; analyzing the frequency dynamics of at least the S1 heart sound as measured by the acceleration sensor. - View Dependent Claims (10, 11)
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12. A system for optimizing CRT lead placement and/or CRT device timing intervals, comprising:
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a test pacing component to perform test pacing of a patient'"'"'s heart; a catheter component, the catheter component including; a portion for insertion within or on a patient'"'"'s heart, the insertion portion including an acceleration sensor to monitor heart sounds responding to the test pacing; an external portion including a connector to carry signals from the acceleration sensor; a signal receiving and analysis component, the signal receiving and analysis component including; a frequency analyzer to analyze the frequency dynamics of at least the S1 heart sound as measured by the acceleration sensor in response to the test pacing. - View Dependent Claims (13, 14, 15, 16, 17)
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18. A method for optimizing CRT lead placement and/or CRT device timing intervals, comprising:
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inserting a catheter into a patient, a distal tip of the catheter including a section that resides within or on a patient'"'"'s heart, the section including an acceleration sensor; inserting a test pacing component within or on a patient'"'"'s heart; test pacing the patient'"'"'s heart; receiving signals from the acceleration sensor at a signal receiving and analysis component in response to the test pacing; analyzing the frequency dynamics of at least the S1 heart sound as measured by the acceleration sensor in response to the test pacing. - View Dependent Claims (19)
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20. A system for monitoring cardiac function, comprising:
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an implantable component, the implantable component including an acceleration sensor and a transmitter; a signal receiving and analysis component, the signal receiving and analysis component including; a receiver to receive signals from the transmitter; and a frequency analyzer to analyze the frequency dynamics of at least the S1 heart sound as measured by the acceleration sensor. - View Dependent Claims (21, 22, 23, 24)
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25. A method for monitoring cardiac function, comprising:
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subcutaneously inserting an implantable component into a patient, the implantable component including an acceleration sensor and a transmitter; receiving signals from the acceleration sensor at a signal receiving and analysis component; receiving signals from a surface electrode disposed on the implantable component; synchronizing the acceleration sensor with a signal received from the surface electrode corresponding to the onset of myocardial contraction; analyzing the frequency dynamics of at least the S1 heart sound as measured by the acceleration sensor. - View Dependent Claims (26, 27)
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28. A system for long-term monitoring of heart failure, comprising:
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a. a housing, including; a) an accelerometer; b) A transceiver chip coupled to the accelerometer; c) A battery coupled to the accelerometer; b. wherein said housing is structured and configured to be implanted sub-cutaneously to monitor vibrational motion of the heart. - View Dependent Claims (29, 30, 31, 32, 33)
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34. A method for monitoring cardiac function, comprising:
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c. installing an acceleration sensor within or on a patient'"'"'s heart; d. installing a surface ECG electrode and measuring a patient'"'"'s surface ECG; and e. sensing vibrational motion in a time window following the R-wave measured by the surface ECG. - View Dependent Claims (35, 36, 37, 38)
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39. A method for optimizing CRT device timing intervals, comprising:
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test pacing a patient'"'"'s heart; monitoring heart sounds responding to the test pacing using an acceleration sensor; receiving signals corresponding to the monitored heart sounds; analyzing the frequency dynamics of the received signals; varying an AV or VV timing interval of the test pacing while analyzing the changes of the varying on the frequency dynamics. - View Dependent Claims (40, 41, 42)
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Specification