EPIDERMAL GROWTH FACTOR INCREASING INSULIN SECRETION AND LOWERING BLOOD GLUCOSE
First Claim
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1. A pharmaceutical composition for preventing or treating diabetes mellitus comprising EGF and a pharmaceutically acceptable carrier.
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Abstract
The present inventors show that a brief exposure to EGF stimulates insulin secretion glucose-independently via a Ca2+ influx- and PLD2-dependent mechanism. Furthermore, the present invention shows that EGF is a novel secretagogue that lowers plasma glucose levels in normal and diabetic mice, suggesting the potential for EGF treatment in diabetes.
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20 Claims
- 1. A pharmaceutical composition for preventing or treating diabetes mellitus comprising EGF and a pharmaceutically acceptable carrier.
- 7. A method for controlling blood glucose levels in a subject in need thereof comprising administering an effective amount of EGF to the subject.
- 8. A method for controlling blood insulin levels in a subject in need thereof comprising administering an effective amount of EGF to the subject.
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