UNIFYING MECHANISM AND METHODS TO PREVENT CANCER AND NEURODEGENERATIVE DISEASES
First Claim
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1. A method for preventing cancer in a mammal comprising administering to the mammal an effective amount of N-acetylcysteine or a pharmaceutically acceptable salt thereof.
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Abstract
The present invention relates to methods for preventing the development of cancer or neurodegenerative diseases by administering N-Acetylcysteine (NAC), melatonin, or a combination thereof. The present invention also relates to methods for diagnosing cancer and/or neurdegenerative disease by detecting or determining the amount of dopamine metabolites, 4-CE, 2-CE, methylation of CE or CE-Q conjugates.
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15 Claims
- 1. A method for preventing cancer in a mammal comprising administering to the mammal an effective amount of N-acetylcysteine or a pharmaceutically acceptable salt thereof.
- 7. A method for preventing a pathological condition or symptom in a mammal, such as a human, wherein the production of depurinating DNA adducts from the action of endogenous quinones is implicated and antagonism of such action is desired comprising administering to a mammal in need of such preventive therapy, an effective amount of N-Acetylcysteine, resveratrol, lipoic acid and melatonin or pharmaceutically acceptable salts thereof.
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9. A method for determining a mammal'"'"'s risk of developing cancer comprising:
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a) determining the amount of depurinating DNA adducts present in a physiological sample from the mammal; b) comparing the determined amount to an amount present in a control mammal, wherein an elevated amount of depurinating DNA adducts correlates with the risk of developing cancer. - View Dependent Claims (10, 11, 12, 13, 14, 15)
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