Transmission Fluorometer
First Claim
1. A non-invasive measurement system for determining ratios of concentrations of at least two analytes of a sample, the system comprising:
- a light source configured to provide an output spectrum which excites the at least two analytes;
receiving optics positioned relative to the light source so as to capture fluoresced light emitted by the at least two analytes upon excitation by the light source;
a spectrometric assembly capable of performing quantitative measurements of intensity and wavelength of the fluoresced light emitted by the at least two analytes upon excitation by the light source, wherein the input of the spectrometric assembly is connected to the output of the receiving optics; and
a computer system linked to the spectrometric assembly, the computer system comprising computer readable code for computing and providing as output the ratio of the concentration of one analyte relative to the concentration of at least another analyte
1 Assignment
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Accused Products
Abstract
This disclosure relates generally to a system and method for noninvasive, non-destructive fluorescent measurement. More specifically, the disclosure provides a non-invasive metrology system and method to monitor levels of fluorescent chemicals in the blood. A major application for the invention is field-based non-invasive blood testing for micro-nutrient deficiency and diseases resulting from it, such as Iron deficient anemia. The invention may help reduce or eliminate the need for blood drawing, sending the sample to a blood lab and having to wait for a result.
17 Citations
35 Claims
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1. A non-invasive measurement system for determining ratios of concentrations of at least two analytes of a sample, the system comprising:
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a light source configured to provide an output spectrum which excites the at least two analytes; receiving optics positioned relative to the light source so as to capture fluoresced light emitted by the at least two analytes upon excitation by the light source; a spectrometric assembly capable of performing quantitative measurements of intensity and wavelength of the fluoresced light emitted by the at least two analytes upon excitation by the light source, wherein the input of the spectrometric assembly is connected to the output of the receiving optics; and a computer system linked to the spectrometric assembly, the computer system comprising computer readable code for computing and providing as output the ratio of the concentration of one analyte relative to the concentration of at least another analyte - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method for non-invasively determining ratios of blood analyte concentrations, the method comprising:
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pinching an in vivo skin sample between a light source and an optics system configured to receive radiation; emitting radiation from the light source onto the skin sample, the light source being configured to provide an output spectrum that excites at least two blood analytes; optically receiving fluoresced light emitted by the at least two blood analytes upon excitation by the light source; measuring the intensity and wavelength of the fluoresced light emitted by the at least two blood analytes upon excitation by the light source; and determining a ratio of the concentration of one analyte to the concentration of at least another analyte. - View Dependent Claims (22, 23, 24, 25, 26)
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27. A non-invasive measurement system for determining ratios of concentrations of at least two analytes of a sample, the system comprising:
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a light source configured to provide an output spectrum which excites the at least two analytes; receiving optics positioned relative to the light source so as to capture both excitation light transmitted through the sample and fluoresced light emitted by the at least two analytes upon excitation by the light source; a spectrometric assembly capable of performing quantitative measurements of intensity and wavelength of both excitation light transmitted through the sample and the fluoresced light emitted by the at least two analytes upon excitation by the light source, wherein the input of the spectrometric assembly is connected to the output of the receiving optics; and a computer system linked to the spectrometric assembly, the computer system comprising computer readable code for computing and providing as output the ratio of the concentration of one analyte relative to the concentration of at least another analyte. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35)
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Specification