Pulsatile flux drug delivery
First Claim
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1. A method of treating a mammal comprising the steps of:
- a. introducing a catheter into a distensible tissue of a mammal, said catheter being operably connected to a drug delivery pump, andb. intermittently operating said drug delivery pump for one or more predetermined intervals of time to generate a pulsatile flux of drug through said catheter into said tissue,wherein said time intervals of intermittent pump operation allow sufficient time for said distensible tissue to recoil around said catheter, thereby preventing backflow of said drug along outer wall of said catheter.
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Abstract
A method of delivering a therapeutic fluid to the tissue of a mammal using pulsatile flux to prevent fluid backflow.
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Citations
14 Claims
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1. A method of treating a mammal comprising the steps of:
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a. introducing a catheter into a distensible tissue of a mammal, said catheter being operably connected to a drug delivery pump, and b. intermittently operating said drug delivery pump for one or more predetermined intervals of time to generate a pulsatile flux of drug through said catheter into said tissue, wherein said time intervals of intermittent pump operation allow sufficient time for said distensible tissue to recoil around said catheter, thereby preventing backflow of said drug along outer wall of said catheter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 10, 11, 12)
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9. A method of treating a mammal comprising the steps of:
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a. introducing a catheter into a distensible tissue of a mammal, said catheter being operably connected to a drug delivery pump, and b. operating said drug delivery pump at two or more predetermined rates of flow over two or more predetermined time intervals to generate a pulsatile flux of drug through said catheter into said tissue, wherein the combination of said two or more predetermined rates of flow over two or more predetermined time intervals allow sufficient time for said distensible tissue to recoil around said catheter, thereby preventing backflow of said drug along outer wall of said catheter. - View Dependent Claims (13, 14)
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Specification