METHOD AND COMPOSITION FOR REMOVING UREMIC TOXINS IN DIALYSIS PROCESSES

• US 20090314707A1
• Filed: 05/29/2009
• Published: 12/24/2009
• Est. Priority Date: 11/13/2001
• Status: Abandoned Application

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter International Inc.
• Inventors: Martis, Leo, Donovan, Brian, Karoor, Sujatha, Sanders, Paul J., Mujais, Salim, Lu, Luis, Morti, Stavroula, Hai, Ton That, Soltys, Paul J., Tandon, Rahul, Katada, Mari
• Application Number:
  US12/474,517
• Publication Number:
  US 20090314707A1
• Time in Patent Office: Days
• US Class Current: 210/484
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/284 Continuous flow peritoneal dialysis [CFPD]
• CPC Class Codes: A61M 1/287 Dialysates therefor
• CPC Class Codes: B01D 15/00 Separating processes involving the treatment of liquids with solid sorbents using liquid sorbents B01D11/00; ion exchange processes or materials, sorbent materials in general B01J, e.g. sorbents for chromatography B01J20/281; for investigating or analysing materials G01N30/00; Apparatus therefor
• CPC Class Codes: B01J 20/0211 Compounds of Ti, Zr, Hf
• CPC Class Codes: B01J 20/0292 Phosphates of compounds other than those provided for in B01J20/048
• CPC Class Codes: B01J 20/06 comprising oxides or hydroxides of metals not provided for in group B01J20/04
• CPC Class Codes: B01J 20/20 comprising free carbon; comprising carbon obtained by carbonising processes
• CPC Class Codes: B01J 20/22 comprising organic material
• CPC Class Codes: B01J 20/28052 Several layers of identical or different sorbents stacked in a housing, e.g. in a column
• CPC Class Codes: B01J 39/10 Oxides or hydroxides
• CPC Class Codes: B01J 39/12 Compounds containing phosphorus
• CPC Class Codes: B01J 41/10 Inorganic material

Abstract

Methods and devices for providing dialysis treatment are provided. The device includes a resin bed including zirconium phosphate, zirconium oxide, and urease.

Claims

1. A cartridge for regenerating dialysis solution comprising:

a layer for removing uremic waste from said dialysis solution;

a urea removal layer that rejects calcium and magnesium ions; and

an ion-exchange layer for removing at least phosphate from said dialysis solution.

2. The cartridge of claim 1 wherein the layer for removing uremic waste comprises activated carbon.

3. The cartridge of claim 1 wherein the ion-exchange layer is comprised on an ion-exchange resin.

4. The cartridge of claim 1 wherein the urea removal layer further comprises:

an enzyme to degrade the urea; and

an ion-exchange sorbent to absorb the urea degradation products.

5. The cartridge of claim 4 wherein the enzyme to degrade the urea is urease.

6. The cartridge of claim 4 wherein the ion exchange sorbent is a zirconium phosphate resin.

7. The cartridge of claim 1 wherein the dialysis solution is peritoneal dialysis solution.

8. The cartridge of claim 1, wherein the layer for removing uremic waste removes uremic waste selected from the group consisting of creatinine, uric acid, and combinations thereof.

10. The cartridge of claim 1, wherein the ion-exchange layer further removes sodium.

9. (canceled)