Mechanically-Actuated Microfluidic Diaphragm Valve

• US 20090314972A1
• Filed: 06/20/2008
• Published: 12/24/2009
• Est. Priority Date: 06/20/2008
• Status: Active Grant

• Current Assignee: Silverbrook Research Pty Limited
• Original Assignee: Silverbrook Research Pty Limited
• Inventors: Silverbrook, Kia, Kerr, Emma Rose, McAvoy, Gregory John
• Granted Patent: US 8,092,761 B2
• Time in Patent Office: Days
• US Class Current: 251/11
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 2400/0481 squeezing of channels or chambers
• CPC Class Codes: B01L 2400/0633 with moving parts
• CPC Class Codes: B01L 2400/0655 pinch valves
• CPC Class Codes: B01L 3/50273 characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043
• CPC Class Codes: B01L 3/502738 characterised by integrated valves microvalves F16K99/0001
• CPC Class Codes: C08L 2201/12 Shape memory
• CPC Class Codes: F04B 43/043 Micropumps
• CPC Class Codes: F04B 43/14 having plate-like flexible members
• CPC Class Codes: F16K 2099/008 Multi-layer fabrications
• CPC Class Codes: F16K 2099/0084 Chemistry or biology, e.g. "lab-on-a-chip" technology
• CPC Class Codes: F16K 99/0001 Microvalves microdevices B81B1/00; manufacture or treatment of devices or systems in or on a substrate B81C1/00; microfluidic structures B01L3/5027; micropumps F04B19/006
• CPC Class Codes: F16K 99/0007 of cantilever type
• CPC Class Codes: F16K 99/0038 using shape memory alloys
• CPC Class Codes: Y10T 137/2229 Device including passages having V over T configuration
• CPC Class Codes: Y10T 137/9138 Flexible

Abstract

A microfluidic diaphragm valve. The valve comprises: an inlet port; an outlet port; a weir positioned between the inlet and outlet ports, the weir having a sealing surface; a diaphragm membrane for sealing engagement with the sealing surface; and a thermal bend actuator for moving the diaphragm membrane between a closed position in which the membrane is sealingly engaged with the sealing surface and an open position in which the membrane is disengaged from said sealing surface.

Claims

1. A microfluidic valve comprising:

an inlet port;

an outlet port;

a weir positioned between said inlet and outlet ports, said weir having a sealing surface;

a diaphragm membrane for sealing engagement with said sealing surface; and

at least one thermal bend actuator for moving said diaphragm membrane between a closed position in which said membrane is sealingly engaged with said sealing surface and an open position in which said membrane is disengaged from said sealing surface.

2. The microfluidic valve of claim 1, wherein, in said open position, a connecting channel is defined between said diaphragm membrane and said sealing surface, said connecting channel providing fluidic communication between said inlet and outlet ports.

3. The microfluidic valve of claim 1, wherein said open position includes a fully open position and a partially open position.

4. The microfluidic valve of claim 1, wherein said diaphragm membrane is fused or bonded to at least one moveable finger, said actuator causing movement of said finger.

5. The microfluidic valve of claim 4, wherein said at least one finger comprises said thermal bend actuator.

6. The microfluidic valve of claim 4 comprising a pair of opposed fingers, each of said fingers pointing towards said weir, wherein said diaphragm membrane bridges between said opposed fingers.

7. The microfluidic valve of claim 6, wherein said valve is formed on a substrate, said diaphragm membrane and said fingers being spaced apart from said substrate, and said weir extending from said substrate towards said diaphragm membrane.

8. The microfluidic valve of claim 6, wherein said weir is positioned centrally between said opposed fingers.

9. The microfluidic valve of claim 6, wherein each of said fingers comprises a respective thermal bend actuator.

10. The microfluidic valve of claim 9, wherein each thermal bend actuator comprises:

an active beam comprised of a thermoelastic material; and

a passive beam mechanically cooperating with said active beam, such that when a current is passed through the active beam, the active beam heats and expands relative to the passive beam, resulting in bending of the actuator.

11. The microfluidic valve of claim 10, wherein an extent of each finger is defined by said passive beam.

12. The microfluidic valve of claim 10, wherein said active beam is fused to said passive beam.

13. The microfluidic valve of claim 10, wherein said active beam defines a bent current path extending between a pair of electrodes, said electrodes being connected to control circuitry for controlling each actuator.

14. The microfluidic valve of claim 10, wherein said thermoelastic material is selected from the group comprising:

titanium nitride, titanium aluminium nitride and vanadium-aluminium alloys.

15. The microfluidic valve of claim 10, wherein said passive beam is comprised of a material selected from the group comprising:

silicon oxide, silicon nitride and silicon oxynitride.

16. The microfluidic valve of claim 7, wherein said substrate comprises control circuitry for controlling said at least one actuator.

17. The microfluidic valve of claim 16, wherein said substrate is a silicon substrate having said control circuitry contained in at least one CMOS layer thereof.

18. The microfluidic valve of claim 1, wherein said diaphragm membrane is defined by at least part of a polymeric layer.

19. The microfluidic valve of claim 18, wherein said polymeric layer is comprised of polydimethylsiloxane (PDMS).

20. A peristaltic pump comprising a plurality of valves according to claim 1 arranged in series.