CHIMERIC IMMUNOMODULATORY COMPOUNDS AND METHODS OF USING THE SAME-II
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Abstract
The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds.
108 Citations
62 Claims
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1-33. -33. (canceled)
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34. A chimeric immunomodulatory compound (CIC) comprising a core structure with the formula [Nv]X—
- Sp, wherein Sp is a multivalent spacer moiety covalently bonded to X independently selected nucleic acid moieties (Nv), wherein the nucleic acid moieties are between 3 and 7 nucleotides, wherein X is at least 3, wherein said multivalent spacer moiety is selected from the group consisting of a polysaccharide, glycerol, substituted glycerol, tetraminobenzene, heptaminobetacyclodextrin, 1,3,5-trihydroxycyclohexane, pentaerythritol, 1,3-diamino-2-propanol, substituted derivatives of 1,3,-diamino-2-propanol, [propyloxymethyl]ethyl compounds, tetraminopentaerythritol, 1,4,8,11-tetraazacyclotetradecane, 1,4,7,10-tetraazacyclododecane, polyethyleneimino, or a 2-(hydroxymethyl)ethyl moiety, and wherein said CIC further comprises at least one additional non-nucleic acid spacer moiety.
- View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54)
- 55. A chimeric immunomodulatory compound (CIC) having a structure selected from the group consisting of
Specification