METHODS OF DETERMINING ANTIBIOTIC RESISTANCE
First Claim
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1. A method of determining antibiotic resistance, the method comprising the steps of:
- (a) obtaining nucleic acid from a bacterium;
(b) imaging the nucleic acid;
(c) obtaining a restriction map of the nucleic acid;
(d) comparing the restriction map of the nucleic acid with a restriction map database; and
(e) determining antibiotic resistance of the bacterium by matching regions of said nucleic acid to corresponding regions in said database.
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Abstract
This disclosure relates to methods of determining an antibiotic resistance profile of a bacterium, and methods of treating a patient with a therapeutically effective antibiotic. The methods include comparing the restriction map of the nucleic acid with a restriction map database, and determining antibiotic resistance of the bacterium by matching regions of the nucleic acid to corresponding regions in the database.
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Citations
35 Claims
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1. A method of determining antibiotic resistance, the method comprising the steps of:
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(a) obtaining nucleic acid from a bacterium; (b) imaging the nucleic acid; (c) obtaining a restriction map of the nucleic acid; (d) comparing the restriction map of the nucleic acid with a restriction map database; and (e) determining antibiotic resistance of the bacterium by matching regions of said nucleic acid to corresponding regions in said database. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 18, 19)
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20. A method of determining an antibiotic resistance profile of a bacterium, the method comprising the steps of:
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obtaining nucleic acid from a bacterium; preparing an optical map of said nucleic acid; identifying at least one motif present in said nucleic acid that is indicative of bacterial resistance; and correlating said at least one motif with resistance to one or more antibiotics, thereby to determine the antibiotic resistance profile for said bacterium. - View Dependent Claims (21, 22)
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23. A method of determining a therapeutically effective antibiotic for treating a subject, the method comprising:
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(a) obtaining a sample from a patient, wherein the sample is suspected to contain an infectious organism; (b) obtaining a nucleic acid from the organism; (b) preparing an optical map of said nucleic acid (d) determining an antibiotic resistance profile of said organism by comparing said optical map with at least one database containing antibiotic resistance data; and (e) selecting a therapeutically effective antibiotic for treating said patient. - View Dependent Claims (17, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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Specification