COMPOUNDS AND METHODS FOR PROMOTING SMOKING CESSATION
1 Assignment
0 Petitions
Accused Products
Abstract
Compounds and methods for promoting smoking cessation. The compounds may be used to treat a variety of other conditions and disease states.
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Citations
117 Claims
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1-71. -71. (canceled)
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72. A method of treating depression, comprising administering to a patient in need thereof an effective amount of a compound represented by formula (II):
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wherein A3 is —
R, —
N(R)2, —
C(═
NR)N(R)2, or —
OR;each Q is, independently, C—
X or N, wherein one Q is N and each other Q is C—
X;each X is, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —
OH, —
OR, —
CH2—
CO2R, —
CO—
R, —
CO2R, —
N(R)2, —
NR—
CO—
R, —
CO—
N(R)2, —
NRCO2R, —
SO3CF3, —
NO2, —
N3, —
CF3, —
CH═
CHY, or —
CN, with the proviso that at least one X is represented by the formula;each S is, independently, halogen, alkyl, alkenyl, alkynyl, phenyl, aralkyl, —
OH, —
OR, —
CH2—
CO2R, —
CO—
R, —
CO2R, —
N(R)2, —
NR—
CO—
R, —
CO—
N(R)2, —
NRCO2R, —
SO3CF3, —
NO2, —
N3, —
CF3, —
CH═
CHY, or —
CN, or two S, taken together with the phenyl group to which they are bonded, form a 2-naphthyl group;c is 1, 2, 3, 4 or 5; Y is a halogen; and each R is, independently, H, alkyl, alkenyl, alkynyl, aryl, or aralkyl; or a pharmaceutically acceptable salt thereof. - View Dependent Claims (73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117)
wherein A3 is as defined in claim 72; X1, X2, X3 and X4 are each, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —
OH, —
OR, —
CH2—
CO2R, —
CO—
R, —
CO2R, —
N(R)2, —
NR—
CO—
R, —
CO—
N(R)2, —
NRCO2R, —
SO3CF3, —
NO2, —
N3, —
CF3, —
CH═
CHY, or —
CN, wherein at least one of X1, X2, X3, and X4 is represented by said formula;wherein S and c are as defined in claim 72; Y is as defined in claim 72; and R is as defined in claim 72.
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90. The method of claim 89, wherein the compound is represented by formula (IIb):
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wherein A3 is as defined in claim 89; X1, X3 and X4 are each, independently, H, halogen, alkyl, alkenyl, alkynyl, aryl, aralkyl, —
OH, —
OR, —
CH2—
CO2R, —
CO—
R, —
CO2R, —
N(R)2, —
NR—
CO—
R, —
CO—
N(R)2, —
NRCO2R, —
SO3CF3, —
NO2, —
N3, —
CF3, —
CH═
CHY, or —
CN;R is as defined in claim 89; Y is as defined in claim 89; S is as defined in claim 89; and c is as defined in claim 89.
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91. The method of claim 90, wherein c is 1.
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92. The method of claim 90, wherein c is 2.
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93. The method of claim 90, wherein c is 3.
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94. The method of claim 90, wherein two of said S, taken together with the phenyl group to which they are bonded, form a 2-naphthyl group.
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95. The method of claim 90, wherein c is 1, 2, 3, 4, or 5, and at least one S is halogen, alkyl, alkenyl, alkynyl, —
- OH, —
OR, —
CH2—
CO2R, —
CO—
R, —
CO2R, —
N(R)2, —
NR—
CO—
R, —
CO—
N(R)2, —
NRCO2R, —
SO3CF3, —
NO2, —
N3, —
CF3, —
CH═
CHY, or —
CN, wherein R and Y are as defined in claim 90.
- OH, —
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96. The method of claim 90, wherein c is 1, 2, 3, 4, or 5, and at least one S is halogen, alkyl, or —
- NO2.
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97. The method of claim 90, wherein c is 1, 2, or 3, and at least one S is halogen, alkyl, or —
- NO2.
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98. The method of claim 90, wherein c is 1 or 2, and at least one S is halogen, alkyl, or —
- NO2.
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99. The method of claim 90, wherein at least one of X1, X3, and X4 is halogen or —
- NH2.
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100. The method of claim 90, wherein at least one of X1, X3, and X4 is halogen, —
- OH, —
OR, —
CH2—
CO2R, —
CO—
R, —
CO2R, —
N(R)2, —
NR—
CO—
R, —
CO—
N(R)2, —
NRCO2R, —
SO3CF3, —
NO2, —
N3, —
CF3, —
CH═
CHY, or —
CN, wherein R is as defined in claim 90.
- OH, —
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101. The method of claim 90, wherein A3 is H or alkyl.
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102. The method of claim 90, wherein A3 is H.
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103. The method of claim 90, wherein X1, X3, and X4 are each hydrogen.
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104. The method of claim 90, wherein R is H, alkyl or benzyl.
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105. The method of claim 90, wherein said alkyl group in the definition of R is represented by the formula —
- (CH2)n—
Y, wherein Y is a halogen and n is an integer from 1 to 8.
- (CH2)n—
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106. The method of claim 90, wherein X1 is fluorine and X3 and X4 are hydrogen.
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107. The method of claim 106, wherein c is 1.
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108. The method of claim 107, wherein S is fluorine, chlorine, methoxy, —
- NO2 or —
NH2.
- NO2 or —
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109. The method of claim 108, wherein A3 is hydrogen.
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110. The method of claim 90, wherein X1 is —
- Cl, —
Br, NH2 or OH and X3 and X4 are hydrogen.
- Cl, —
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111. The method of claim 110, wherein c is 1.
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112. The method of claim 111, wherein S is —
- Cl, —
Br, —
F, —
NO2, methoxy, —
NH2 or N(CH3)3.
- Cl, —
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113. The method of claim 112, wherein A3 is hydrogen.
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114. The method of claim 72, wherein at least one atom in the compound is a member selected from the group consisting of 3H, 11C, 14C, 35S, 18F, 123I, 125I, and 131I.
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115. The method of claim 114, wherein at least one atom in the compound is a member selected from the group consisting of 3H, 11C, 18F, and 123I.
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116. The method of claim 114, wherein at least one X is 18F, 123I, 125I, or 131I.
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117. The method of claim 114, wherein at least one X is a phenyl group substituted with one or more of 18F, 123I, 125I, or 131I.
Specification