METHOD AND APPARATUS FOR PACING AND INTERMITTENT ISCHEMIA

• US 20090318749A1
• Filed: 06/15/2009
• Published: 12/24/2009
• Est. Priority Date: 06/19/2008
• Status: Abandoned Application

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Mokelke, Eric A., Shuros, Allan C., Arcot-Krishnamurthy, Shantha, Stolen, Craig
• Application Number:
  US12/484,822
• Publication Number:
  US 20090318749A1
• Time in Patent Office: Days
• US Class Current: 600/17
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61F 2/95 Instruments specially adapted for placement or removal of stents or stent-grafts
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/3625 External stimulators
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/36571 controlled by blood flow rate, e.g. blood velocity or cardiac output

Abstract

A system delivers multiple enhanced therapies to limit myocardial damage post-revascularization. The system includes a catheter that incorporates features for delivering cardiac protection pacing therapy (CPPT) and intermittent ischemia therapy. In one embodiment, a method for delivering cardiac protection therapies to a heart is provided. One or more catheters are provided having a balloon, at least one pacing electrode and at least one hemodynamic sensor. Cardiac protection pacing therapy (CPPT) and intermittent ischemia therapy are concurrently delivered using the one or more catheters. The pacing and ischemia are adapted to protect the heart from ischemic and reperfusion injuries. The delivery of the CPPT and the intermittent ischemia are controlled using a closed-loop system monitoring a signal sensed by the at least one hemodynamic sensor.

Claims

1. A system for delivering cardiac protection therapies to a heart via a blood vessel, comprising:

a catheter having at least one balloon along its length, the balloon adapted to be placed in the blood vessel to at least partially occlude the blood vessel;

at least one pacing electrode along the length of the catheter;

at least one hemodynamic sensor near a tip of the catheter; and

a controller connected to the catheter and adapted to sense a hemodynamic parameter being a measure of hemodynamic performance using the hemodynamic sensor, and adapted to control inflation and deflation of the balloon to provide intermittent ischemia, and further adapted to control pulses to the at least one pacing electrode to provide cardiac protection pacing therapy (CPPT).

2. The system of claim 1, wherein the at least one balloon includes a spiral balloon, the spiral balloon adapted to enable vessel wall contact of the pacing electrode during periods of reperfusion while maintaining blood flow.

3. The system of claim 1, wherein the at least one balloon includes two balloons adapted to assist in delivering cardiac protection therapies.

4. The system of claim 3, wherein the two balloons include:

an outer balloon facing the vessel wall, the outer balloon applying pressure against the vessel wall without filling an inner lumen of the spiral; and

an inner balloon facing a vessel lumen, the inner balloon adapted to fill to occlude blood flow.

5. The system of claim 4, wherein at least one electrode is incorporated onto the outer balloon.

6. The system of claim 1, wherein the catheter and balloon are asymmetrically shaped, and the balloon is adapted to maintain contact between an electrode incorporated onto the balloon and the vessel wall when the balloon is inflated.

7. The system of claim 1, wherein the catheter includes a positive flow balloon catheter that includes one or more blood flow channels that can be opened and closed using multiple lumen balloons.

8. The system of claim 1, wherein delivery of the CPPT and the intermittent ischemia are controlled using a closed-loop system monitoring the hemodynamic parameter.

9. The system of claim 1, wherein the at least one hemodynamic sensor includes a pressure sensor.

10. The system of claim 1, further comprising:

at least one sensing electrode along the length of the catheter.

11. The system of claim 1, wherein the catheter is adapted to deploy a stent.

12. A system for delivering cardiac protection therapies to a heart via a blood vessel, comprising:

a catheter having a balloon along its length, the balloon adapted to be placed in the blood vessel to at least partially occlude the blood vessel;

a guide wire adapted to guide placement of the catheter, the guide wire including at least one hemodynamic sensor;

at least one pacing electrode along the length of one of the catheter and the guide wire; and

a controller connected to the catheter and adapted to sense a hemodynamic parameter being a measure of hemodynamic performance using the hemodynamic sensor, and adapted to control inflation and deflation of the balloon to provide intermittent ischemia, and further adapted to control pulses to the at least one pacing electrode to provide cardiac protection pacing therapy (CPPT).

13. The system of claim 12, wherein the guide wire including the at least one hemodynamic sensor includes a flow sensor.

14. The system of claim 12, wherein the guide wire including the at least one hemodynamic sensor includes a pressure sensor.

15. A method for delivering cardiac protection therapies to a heart, comprising:

providing one or more catheters having a balloon, at least one pacing electrode and at least one hemodynamic sensor;

concurrently delivering cardiac protection pacing therapy (CPPT) and intermittent ischemia therapy using the catheter, the pacing and ischemia adapted to protect the heart from ischemic and reperfusion injuries; and

controlling the delivery of the CPPT and the intermittent ischemia using a closed-loop system monitoring a signal sensed by the at least one hemodynamic sensor.

16. The method of claim 15, wherein concurrently delivering CPPT and intermittent ischemia includes alternately delivering CPPT and intermittent ischemia.

17. The method of claim 15, wherein concurrently delivering CPPT and intermittent ischemia includes simultaneously delivering CPPT and intermittent ischemia.

18. The method of claim 15, wherein concurrently delivering CPPT and intermittent ischemia includes delivering CPPT when the balloon is deflated.

19. The method of claim 15, wherein delivering intermittent ischemia therapy includes inflating and deflating the balloon.

20. The method of claim 19, wherein inflating and deflating the balloon is related to an electrocardiogram.

21. The method of claim 20, wherein inflating and deflating the balloon is done on a periodic basis having a period, wherein the period is based on a number of R-waves in the electrocardiogram.

22. The method of claim 15, wherein providing one or more catheters having a balloon includes providing a spiral balloon adapted to enable vessel wall contact of the pacing electrode during periods of reperfusion while maintaining blood flow.

23. The method of claim 15, wherein providing one or more catheters having a balloon includes providing an asymmetrically shaped balloon that contacts the vessel wall during inflation while still allowing blood to perfuse through the balloon.

24. The method of claim 15, wherein providing one or more catheters having at least one hemodynamic sensor includes providing a flow sensor.

25. The method of claim 15, wherein providing one or more catheters having at least one hemodynamic sensor includes providing a pressure sensor.