METHOD FOR DIAGNOSIS OF AN INFECTIOUS DISEASE STAGE AND DETERMINATION OF TREATMENT
First Claim
1. A method for identifying which mammals in an identified group of mammals has one or more diseases selected from the group consisting of infectious and inflammatory diseases and should also receive treatment for the one or more diseases comprising:
- a) obtaining leukocyte data on each of the mammals in the group;
b) determining the relationship of major and minor microbial pathogens in the group;
c) dividing the leukocyte data from the group into essentially non-overlapping subsets based on evaluating the leukocyte data based on at least one of linearity and microbial profile;
d) identifying at least 3 subsets representing disease stages wherein each subset exhibits statistical differences in at least one of leukocyte data and microbial data;
e) assessing the relative time involvement of each subset, in which there is no infection, early infection and late infection; and
f) determining if the mammals in each subset should receive treatment.
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Abstract
The present invention relates to a means for determining if mammals within a group of mammals is affected by an infection that induces or could induce inflammation, if the mammal is likely to recover or not and if infected whether the mammal should be treated or let to recover untreated. By differentiating infected mammals in a group into different subsets representing differing stages of the progress of the disease the present invention teaches how to prognosticate with continuous data the outcome of a treatment/no treatment decision.
10 Citations
17 Claims
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1. A method for identifying which mammals in an identified group of mammals has one or more diseases selected from the group consisting of infectious and inflammatory diseases and should also receive treatment for the one or more diseases comprising:
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a) obtaining leukocyte data on each of the mammals in the group; b) determining the relationship of major and minor microbial pathogens in the group; c) dividing the leukocyte data from the group into essentially non-overlapping subsets based on evaluating the leukocyte data based on at least one of linearity and microbial profile; d) identifying at least 3 subsets representing disease stages wherein each subset exhibits statistical differences in at least one of leukocyte data and microbial data; e) assessing the relative time involvement of each subset, in which there is no infection, early infection and late infection; and f) determining if the mammals in each subset should receive treatment. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of determining the disease state of an individual mammal in a group of mammals comprising:
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a) dividing the group into a plurality of biological profile subsets; b) evaluating the profile subsets for their relevance to disease prognosis; and c) determining the individual mammal'"'"'s disease state by assessing which subset the individual mammal is a member of.
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8. A method of differentiating the health of a mammal in a group of mammals by evaluating at least two indicators selected from the group comprising the macrophage percentage, the ratio of PMN/lymphocyte percentages, the mononuclear percentage and the PMN/macrophage ratio.
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9. A method of identifying the progress of an inflammatory infection and the prognosis of the progress of the disease in a mammal which is a member of a group of mammals comprising the steps of:
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a) determining which members of the group do not have an infection and which have an infection; b) separating those which have an infection into early inflammatory infection and late inflammatory; c) determining the recovery index for each of the members of the late infection group; d) determining the inflammatory index for each of the members of the late infection group; e) based on the determined recovery index and inflammatory index of all the members of the late infection group, dividing the group into at least 4 sub-populations comprising an active infection group where major pathogens predominate, an inactive infection group where minor pathogens predominate, a transitional infection group where major pathogens predominate but inflammation is marginal or not observed and an infection without inflammation group where major pathogen predominate; and f) determining for the mammals that have a late infection to which sub-population the mammal is a member of. - View Dependent Claims (10, 11, 12, 13, 14)
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15. A method for identifying which mammals in an identified group of mammals have an infectious disease and should also receive treatment for the disease comprising:
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a) obtaining leukocyte data on each of the mammals in the group; b) obtaining microbial profile data on each of the mammals in the group; c) dividing the mammals in the group into essentially non-overlapping subsets based on evaluating the leukocyte data based on at least one of linearity and microbial profile; d) identifying at least 3 subsets which indicate no infection, early infection or late infection; and e) determining if the mammals in each subset should receive treatment.
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16. A method for identifying mammals from a group of infected mammals that do not require treatment comprising evaluating leukocyte data and based on those data not treating mammals which fall into no infection, late transition and late inactive infection groups.
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17. A method for identifying sources of diagnostic errors in the process of testing a group of mammals for an infective inflammatory disease comprising:
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a) producing a leukocyte profile which identifies at least 4 potential diagnostic errors in the testing; b) producing a microbial profile from the leukocyte profile data of each individual mammal; and c) determining the most likely diagnosis for one or more mammals in the group of mammals based on the microbial profile and the leukocyte profile of the disease stage.
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Specification