METHOD OF MEASURING BLOOD COMPONENT AND SENSOR USED IN THE METHOD

• US 20090321281A1
• Filed: 08/19/2009
• Published: 12/31/2009
• Est. Priority Date: 10/02/2003
• Status: Abandoned Application

• Current Assignee: Panasonic Corporation (Panasonic Holdings Corporation)
• Original Assignee: Panasonic Corporation (Panasonic Holdings Corporation)
• Inventors: SHINNO, Teppei, IKEDA, Shin
• Application Number:
  US12/543,713
• Publication Number:
  US 20090321281A1
• Time in Patent Office: Days
• US Class Current: 205/792
• CPC Class Codes: C12Q 1/001 Enzyme electrodes
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose
• CPC Class Codes: G01N 33/721 Haemoglobin

Abstract

A sensor for blood component analysis that can correct the effect of a hematocrit easily is provided. The sensor includes an analysis portion including a working electrode, a counter electrode, and a reagent portion. The reagent portion includes an oxidoreductase that reacts with the blood component and a mediator, and the blood component is measured by causing a redox reaction between the blood component and the oxidoreductase in the presence of the mediator and detecting a redox current generated by the redox reaction by the working electrode and the counter electrode. In this sensor, the reagent portion further includes a hemolyzing agent (e.g., sodium cholate) for hemolyzing an erythrocyte, and when detecting the redox current, the erythrocyte is hemolyzed with the hemolyzing agent so as to cause hemoglobin released to an outside of the erythrocyte to react with the mediator and a current generated by this reaction also is detected to correct an effect of a hematocrit.

Claims

1-20. -20. (canceled)

21. A sensor for measuring a blood component, comprising:

a reagent portion;

a channel for leading blood; and

an air vent hole,

wherein blood is led to the reagent portion through the channel for leading blood by capillary action due to the air vent hole, and an error that counterbalances an error of a material that has an effect on the sensor is obtained from the material, thereby counterbalancing the error having the effect of the sensor.

22. The sensor according to claim 21, wherein the error that has the effect on the sensor and the error that counterbalances the error having the effect are obtained with respect to an amperometric response.

23. The sensor according to claim 21, wherein the error that has the effect on the sensor is a negative error, and the error that counterbalances the error having the effect is a positive error.

24. A method that uses a sensor for measuring a blood component, comprising:

a reagent portion;

a channel for leading blood; and

an air vent hole;

the method comprising;

leading blood to the reagent portion through the channel for leading blood by capillary action due to the air vent hole; and

obtaining an error that counterbalances an error of a material that has an effect on the sensor from the material, thereby counterbalancing the error having the effect on the sensor.

25. The method according to claim 24, wherein the error that has the effect on the sensor and the error that counterbalances the error having the effect are obtained with respect to the amperometric response.

26. The sensor according to claim 24, wherein the error that has the effect on the sensor is a negative error, and the error that counterbalances the error having the effect is a positive error.