BIOCOMPATIBLE CROSSLINKED HYDROGELS, DRUG-LOADED HYDROGELS AND METHODS OF USING THE SAME
13 Assignments
0 Petitions
Accused Products
Abstract
Disclosed are hydrogel compositions formed by the mixture of a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more electrophilic groups, and a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more nucleophilic groups. Disclosed are also methods of preparing the above hydrogels. The hydrogel compositions can further comprise pharmaceuticals, such as analgesics or local anesthetics. Disclosed are also methods of sealing a wound, preventing post-surgical adhesion, and reducing post-surgical pain using the disclosed hydrogels.
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Citations
111 Claims
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1-2. -2. (canceled)
- 3. A composition comprising a compound of Formula I.2:
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4-6. -6. (canceled)
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8-13. -13. (canceled)
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14. A hydrogel composition produced by a method comprising:
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mixing a first compound and a second compound to obtain a first mixture, adding a first aqueous solution to the first mixture to obtain a first solution, adding a second aqueous solution to the first solution, wherein the first compound is a compound of Formula I; - View Dependent Claims (15, 18, 21, 25, 28)
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16-17. -17. (canceled)
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19-20. -20. (canceled)
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22-24. -24. (canceled)
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26-27. -27. (canceled)
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29-53. -53. (canceled)
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54. A composition comprising a biocompatible hydrogel and a drug, wherein the biocompatible hydrogel is produced by a method comprising:
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mixing a first compound and a second compound to obtain a first mixture, adding a first aqueous solution to the first mixture to obtain a first solution, adding a second aqueous solution to the first solution, wherein, the first compound is a compound of Formula I; - View Dependent Claims (56, 60, 63, 66, 67, 71, 72, 111)
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55. (canceled)
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57-59. -59. (canceled)
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61-62. -62. (canceled)
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64-65. -65. (canceled)
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68-70. -70. (canceled)
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73-110. -110. (canceled)
Specification