METHODS FOR MAKING ANTIMICROBIAL COATINGS

• US 20090324738A1
• Filed: 06/30/2008
• Published: 12/31/2009
• Est. Priority Date: 06/30/2008
• Status: Abandoned Application

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Inventors: KRONGAUZ, VADIM V.
• Application Number:
  US12/164,414
• Publication Number:
  US 20090324738A1
• Time in Patent Office: Days
• US Class Current: 424/618
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/14 Materials characterised by their function or physical properties , e.g. lubricating compositions
• CPC Class Codes: C23C 18/1662 Use of incorporated material in the solution or dispersion, e.g. particles, whiskers, wires
• CPC Class Codes: C23C 18/1676 Heating of the solution
• CPC Class Codes: C23C 18/1689 After-treatment
• CPC Class Codes: C23C 18/31 Coating with metals
• CPC Class Codes: C23C 18/44 using reducing agents

Abstract

Methods for forming antimicrobial coatings on substrate surfaces are disclosed. The methods involve providing a mixture comprising a metal salt, a biguanide compound, and a reducing agent, wherein the mixture is free of polymeric binders; and depositing the mixture onto a substrate surface, thereby forming a coated substrate surface.

Claims

1. A method for forming an antimicrobial coating on a substrate surface comprising:

providing a mixture comprising a transition metal, a biguanide compound, and a reducing agent, wherein the mixture is free of polymeric binders; and

depositing the mixture onto a substrate surface, thereby forming a coated substrate surface.

2. The method of claim 1, wherein the substrate surface comprises at least one plastic, glass, metal, ceramic, elastomer, or mixtures or laminates thereof.

3. The method of claim 1, wherein the substrate surface comprises a plastic or elastomer selected from the group consisting of acrylonitrile butadiene styrenes, polyacrylonitriles, polyamides, polycarbonates, polyesters, polyetheretherketones, polyetherimides, polyethylenes, polyethylene terephthalates, polylactic acids, polymethyl methyacrylates, polypropylenes, polystyrenes, polyurethanes, poly(vinyl chlorides), polyvinylidene chlorides, polyethers, polysulfones, silicones, natural rubbers, synthetic rubbers, styrene butadiene rubbers, ethylene propylene diene monomer rubbers, polychloroprene rubbers, acrylonitrile butadiene rubbers, chlorosuphonated polyethylene rubbers, polyisoprene rubbers, isobutylene-isoprene copolymeric rubbers, chlorinated isobutylene-isoprene copolymeric rubbers, brominated isobutylene-isoprene copolymeric rubbers, and blends and copolymers thereof.

4. The method of claim 1, wherein the substrate surface comprises a surface of a medical device or medical device component.

5. The method of claim 1, wherein the substrate surface comprises a surface of a medical fluid container or medical fluid flow system.

6. The method of claim 1, wherein the substrate surface comprises a surface of an I.V. set.

7. The method of claim 1, wherein the substrate surface comprises a surface of a medical device or medical device component selected from the group consisting of:

I.V. tubing, I.V. fluid bags, access devices for I.V. sets, septa, stopcocks, I.V. set connectors, I.V. set adaptors, clamps, I.V. filters, catheters, needles, and cannulae.

8. The method of claim 1, wherein the substrate surface comprises a surface of a luer access device or a needleless luer access device.

9. The method of claim 1, wherein the transition metal comprises a metal selected from the group consisting of silver, copper, gold, zinc, cerium, platinum, palladium, tin, and mixtures thereof.

10. The method of claim 1, wherein the transition metal comprises silver.

11. The method of claim 1, wherein the transition metal is provided as a water-soluble metal salt.

12. The method of claim 1, wherein the transition metal and the biguanide compound are provided as a metal biguanide complex.

13. The method of claim 11, wherein the metal salt is selected from the group consisting of:

metal acetates, metal sulfates, metal nitrates, metal chlorates, metal bromates, metal iodates, and mixtures thereof.

14. The method of claim 11, wherein the metal salt comprises silver nitrate.

15. The method of claim 1, wherein the transition metal comprises particles having a diameter of about 1 nanometer to about 50 micrometers.

16. The method of claim 1, wherein the biguanide compound comprises chlorhexidine or salts thereof.

17. The method of claim 1, wherein the biguanide compound comprises a compound selected from the group consisting of chlorhexidine acetates, chlorhexidine gluconates, chlorhexidine hydrochlorides, chlorhexidine sulfates, carbamimidoyl guanidines, metformin, buformin, phenformin, and mixtures and derivatives thereof.

18. The method of claim 1, wherein the reducing agent comprises an aldehyde selected from the group consisting of acyclic aliphatic aldehydes, cyclic aliphatic aldehydes, aryl aldehydes, aldoses, and mixtures thereof.

19. The method of claim 1, wherein the reducing agent comprises an aldehyde selected from the group consisting of glyceraldehyde, erythrose, threose, ribose, arabinose, xylose, lyxose, allose, altrose, glucose, mannose, gulose, idose, galactose, talose, and mixtures thereof.

20. The method of claim 1, further comprising partially reducing the transition metal.

21. The method of claim 1, wherein the depositing comprises heating the mixture to a temperature of about 40°

C. to about 80°

C.

22. The method of claim 1, further comprising exposing the coated substrate surface to a mixture comprising an oxidizing agent and an anion.

23. The method of claim 22, wherein the exposing occurs for about 0.1 seconds to about 24 hours.

24. The method of claim 22, wherein the oxidizing agent is selected from the group consisting of:

metal ions, metal compounds, halogens, halogen-containing compounds, organic compounds of oxygen, inorganic compounds of oxygen, and mixtures thereof.

25. The method of claim 22, wherein the oxidizing agent is selected from the group consisting of:

Fe³⁺, Fe²⁺, Cu²⁺, Cu⁺, MnO₄⁻

, Ce⁴⁺, IO₃⁻

, I₃⁻

, I₂, BrO₃⁻

, Br₂, Br₃⁻

, Cl₂, NO₃⁻

, O₂, S₂O₈²⁻

, H₂O₂, quinones, fumarate, methylene blue, and mixtures thereof.

26. The method of claim 1, wherein the anion is selected from the group consisting of:

organic oxyanions, inorganic oxyanions, halides, and mixtures thereof.

27. The method of claim 1, wherein the anion is selected from the group consisting of:

acetate, hydroxide, carbonate, oxalate, phosphate, sulfate, fluoride, chloride, bromide, iodide, chlorate, bromate, iodate, amides, sulfonamides, cyanates, cyanides, and mixture thereof.

28. The method of claim 1, wherein the oxidizing agent and the anion are the same.

29. The method of claim 1, wherein the exposing comprises exposing the substrate surface to povidone iodine.

30. The method of claim 1, wherein the exposing comprises exposing the substrate surface to more than one mixture comprising an oxidizing agent and an anion.

31. A coating composition comprising:

an aqueous solution containing a reducing agent and a complex comprising ionic silver and chlorhexidine, wherein the solution is free of polymeric binders.