CITRIC ACID POLYMERS

• US 20090325859A1
• Filed: 06/19/2009
• Published: 12/31/2009
• Est. Priority Date: 09/19/2003
• Status: Abandoned Application

• Current Assignee: Northwestern University
• Original Assignee: Northwestern University
• Inventors: Hoshi, Ryan, Yang, Jian, Ameer, Guillermo
• Application Number:
  US12/488,306
• Publication Number:
  US 20090325859A1
• Time in Patent Office: Days
• US Class Current: 514/1.1
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: C08G 63/06 derived from hydroxycarboxylic acids
• CPC Class Codes: C08G 63/16 Dicarboxylic acids and dihydroxy compounds
• CPC Class Codes: C08G 63/66 Polyesters containing oxygen in the form of ether groups C08G63/42, C08G63/58 take precedence
• CPC Class Codes: C08G 63/685 containing nitrogen

Abstract

The present invention provides polymers (e.g., elastomeric citric acid polymers) and methods of making and using these polymers (e.g., as a biologically active molecule delivery platform). In certain embodiments, the polymer has adsorbed biologically active molecules. In particular embodiments, the polymer comprises pores that are between about 7 and 15 nanometers in diameter. In other embodiments, the polymer comprises poly(1,8 octanediol-co-ctric acid). In certain embodiments, the polymers are made by employing polyethylene glycol dimethyl ether (PEGDM).

Claims

1. A composition comprising an elastomeric citric acid polymer and a plurality of biologically active molecules, wherein said polymer has the formula:

, Where A is a linear aliphatic dihydroxy monomer, C is a linear aliphatic dihydroxy monomer, R is hydrogen or a polymer, and n is an integer greater than 1, and wherein said plurality of biologically active molecules are adsorbed to said nanoporous poly(diol) citrate polymer.

2. The composition of claim 1, wherein A is a linear aliphatic diol comprising between about 2 and about 20 carbons.

3. The composition of claim 1, wherein C is a linear diol comprising between about 2 and about 20 carbons.

4. The composition of claim 1, wherein both A and C are the same linear diol.

5. The composition of claim 1, wherein said polymer is biodegradable.

6. The composition of claim 1, wherein said polymer comprises pores between about 7 and about 15 nanometers.

7. The composition of claim 1, wherein said polymer comprises poly(1,8 octanediol-co-ctric acid).

8. The composition of claim 1, further comprising at least a trace amount of a non-reactive porogen, wherein said non-reactive porogen is impregnated in said polymer.

9. The composition of claim 1, further comprising at least a trace amount of polyethylene glycol dimethyl ether (PEGDM), wherein said PEGDM is impregnated in said polymer.

10. The composition of claim 1, wherein said plurality of biologically active molecules are selected from the group consisting of:

proteins, nucleic acids, drugs, pro-drugs, and small molecules.

11. A composition comprising an elastomeric citric acid polymer having the formula:

, where A is a linear aliphatic dihydroxy monomer, C is a linear aliphatic dihydroxy monomer, R is hydrogen or a polymer, and n is an integer greater than 1.

12. The composition of claim 11, wherein said polymer comprises pores between about 7 and about 15 nanometers.

13. The composition of claim 11, wherein A and C are each linear aliphatic diol comprising between about 2 and about 20 carbons.

14. The composition of claim 11, wherein said pores have a medium diameter of about 9.5 nanometers.

15. The composition of claim 11, further comprising a plurality of biologically active molecules that are absorbed to said polymer.

16. The composition of claim 11, wherein said plurality of biologically active molecules are selected from the group consisting of:

proteins, nucleic acids, drugs, pro-drugs, and small molecules.

17. The composition of claim 11, wherein said polymer is biodegradable.

18. The composition of claim 11, wherein said polymer comprises poly(1,8 octanediol-co-ctric acid).

19. A composition comprising an elastomeric citric acid polymer and at least trace amounts of a non-reactive porogen, wherein said polymer has the formula

, where A is a linear aliphatic dihydroxy monomer, C is a linear aliphatic dihydroxy monomer, R is hydrogen or a polymer, and n is an integer greater than 1.

20. The composition of claim 19, wherein said nonreactive porogen comprises polyethylene glycol dimethyl ether (PEGDM).