ANTISENSE MODULATION OF APOLIPOPROTEIN B EXPRESSION
5 Assignments
0 Petitions
Accused Products
Abstract
Methods for the rapid and long-term lowering of lipid levels in human subjects and for the treatment of conditions associated with elevated LDL-cholesterol and elevated apolipoprotein B are provided.
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Citations
84 Claims
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1-39. -39. (canceled)
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40. A method of reducing serum LDL-cholesterol in a human subject comprising administering to said human subject an oligonucleotide 14 to 30 nucleobases in length, said oligonucleotide comprising the nucleobase sequence “
- GCCTCAGTCTGCTTCGCACC”
(SEQ ID NO;
2), wherein said oligonucleotide is administered during a loading period and a maintenance period. - View Dependent Claims (42, 44, 49, 51, 56, 57, 58, 59, 60, 61, 66)
- GCCTCAGTCTGCTTCGCACC”
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41. (canceled)
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43. (canceled)
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45-48. -48. (canceled)
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50. (canceled)
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52-55. -55. (canceled)
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62-65. -65. (canceled)
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67. A method of reducing serum cholesterol levels in a human subject, comprising:
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selecting a human subject previously unsuccessfully treated by a statin; and administering to said human subject an oligonucleotide 14 to 30 nucleobases in length, said oligonucleotide comprising the nucleobase sequence “
GCCTCAGTCTGCTTCGCACC”
(SEQ ID NO;
2). - View Dependent Claims (68, 69, 70, 71, 72, 73)
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74. A method of using an oligonucleotide 14 to 30 nucleobases in length comprising the nucleobase sequence “
- GCCTCAGTCTGCTTCGCACC”
(SEQ ID NO;
2) in a treatment for reducing serum LDL-cholesterol in a human subject, said method comprising informing said human subject that the administration of said oligonucleotide results in a plasma trough AUC of at least about 2 μ
g·
hr/mL. - View Dependent Claims (75, 76, 77, 78)
- GCCTCAGTCTGCTTCGCACC”
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79. A method of using an oligonucleotide 14 to 30 nucleobases in length comprising the nucleobase sequence “
- GCCTCAGTCTGCTTCGCACC”
(SEQ ID NO;
2) in a treatment for reducing serum LDL-cholesterol in a human subject, said method comprising informing said human subject that the administration of said oligonucleotide results in a plasma trough concentration of at least about 5 ng/mL. - View Dependent Claims (80, 81, 82, 83)
- GCCTCAGTCTGCTTCGCACC”
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84-216. -216. (canceled)
Specification