MICRONEEDLES AND METHODS FOR FABRICATING MICRONEEDLES

• US 20090326415A1
• Filed: 08/28/2006
• Published: 12/31/2009
• Est. Priority Date: 08/28/2006
• Status: Abandoned Application

• Current Assignee: Agency For Science Technology and Research (Government of Singapore)
• Original Assignee: Agency For Science Technology and Research (Government of Singapore)
• Inventors: Lim, Chee Yen
• Application Number:
  US12/439,142
• Publication Number:
  US 20090326415A1
• Time in Patent Office: Days
• US Class Current: 600/573
• CPC Class Codes: A61B 17/205 Vaccinating by means of needles or other puncturing devices
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/150236 Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood
• CPC Class Codes: A61B 5/150244 Rods for actuating or driving the piston, i.e. the cylindrical body that sits inside the syringe barrel, typically with an air tight seal, and slides in the barrel to create a vacuum or to expel blood
• CPC Class Codes: A61B 5/150282 for piercing elements, e.g. blade, lancet, canula, needle
• CPC Class Codes: A61B 5/150984 Microneedles or microblades
• CPC Class Codes: A61B 5/151 Devices specially adapted for taking samples of capillary blood, e.g. by lancets , needles or blades
• CPC Class Codes: A61M 2037/003 having a lumen
• CPC Class Codes: A61M 2037/0053 Methods for producing microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: B29C 33/3878 used as masters for making successive impressions

Abstract

A plastic microneedle comprising: a body portion tapering from a larger end of the body portion towards a tip portion of the body portion; at least one side port; and a lumen extending from the larger end of the body portion and within the body portion of the microneedle, wherein the side port extends into the lumen such that the side port and the lumen are in fluid communication with each other.

Claims

1. A plastic microneedle comprising:

a body portion tapering from a larger end of the body portion towards a tip portion of the body portion;

at least one side port formed in the body portion; and

a lumen extending from the larger end of the body portion and within the body portion of the microneedle, wherein the side port extends into the lumen such that the side port and the lumen are in fluid communication with each other and such that a fluid discharge direction from the side port is inclined with reference to a longitudinal direction of the lumen.

2. The microneedle as claimed in claim 1, wherein the side port is disposed on a side surface of the body portion of the microneedle.

3. The microneedle as claimed in claim 1, comprising two side ports disposed at opposing side surfaces of the body portion of the microneedle.

4. The microneedle as claimed in claim 1 further comprising an extended tip portion formed on the tip portion of the body portion and forming an apex of the microneedle, wherein the extended tip portion comprises a substantially elongate protrusion extending from the tip portion.

5. The microneedle as claimed in claim 4, wherein a geometry of the extended tip portion is different from a geometry of the body portion.

6. The microneedle as claimed in claim 1 wherein the microneedle is made from at least one of a group of polymers consisting of polycarbonate (PC), polystyrene (PS), polyetherimide (PEI), polyetherehterketone (PEEK).

7. The microneedle as claimed in claim 1, wherein the body portion of the microneedle is pyramid shaped, conical shaped, or hexagonal shaped.

8. The microneedle as claimed in claim 1 are fabricated using injection moulding or cast moulding.

9. A platform member comprising an array of microneedles as claimed in claim 1.

21. A use of a microneedle as claimed in claim 1 for injecting liquid into a body.

22. A use of a microneedle as claimed in claim 1 for extracting body fluid from a body.

23. The use as claimed in claim 22, wherein extracting body fluid from the body includes whole blood sampling.

24. The microneedle as claimed in claim 4, wherein a geometry of the extended tip portion is substantially the same as a geometry of the body portion.

10. A method of fabricating a plastic microneedle, the method comprising:

forming a body portion, the body portion tapering from a larger end of the body portion a tip portion of the body portion;

forming at least one side port in the body portion; and

forming a lumen extending from the larger end of the body portion and within the body portion of the microneedle, wherein the side port extends into the lumen such that the side port and the lumen are in fluid communication with each other and such that a fluid discharge direction from the side port is inclined with reference to a longitudinal direction of the lumen.

11. A method as claimed in claim 10 further comprising:

forming an extended tip portion on the tip portion of the body portion and the extended tip portion forming an apex of the microneedle, wherein the extended tip portion comprises a substantially elongate protrusion extending from the tip portion.

12. A method as claimed in claim 10, the method comprising:

forming a master mould comprising a positive shape of the microneedle,

using the master mould to form a secondary mould comprising a cavity comprising a periphery of a negative shape of the microneedle; and

using the secondary mould to form the microneedle.

13. A method as claimed in claim 10, the method comprising:

forming a master mould comprising a positive shape of the microneedle,

using the master mould to form an intermediate mould comprising a cavity comprising a periphery of a negative shape of the microneedle; and

using the intermediate mould to form a secondary mould comprising a cavity defining the periphery of a negative shape of the microneedle.

14. A method as claimed in claim 13, wherein the intermediate mould is made of polymer.

15. A method as claimed in claim 12, wherein the positive shape of the microneedle on the master mould is created by precision wire-cutting.

16. A method as claimed in claim 12, wherein the secondary mould is made of metal.

17. A method as claimed in claim 12, further comprising:

filling the cavity of the secondary mould with a polymer to form the microneedle.

18. A method as claimed in claim 12, the method further comprising:

providing an insert member;

providing the secondary mould, the secondary mould further comprising at least one slot portion for receiving and aligning the insert member such that a leading edge of the insert intersects the periphery of the negative shape of the microneedle;

inserting the insert member into the secondary mould; and

filling the secondary mould with a fill material, wherein

the insert creates the lumen in the microneedle and the intersection of the leading edge of the insert with the periphery of the negative shape of the microneedle creates the side port extending into the lumen such that the lumen and the side port are in fluid communication with each other.

19. The method of fabricating microneedles as claimed in claim 18, wherein the periphery of the negative shape of the microneedle comprises a channel extending from an apex of the negative shape of the microneedle for forming the extended tip portion of the microneedle.

20. The method of fabricating microneedles as claimed in claim 19, further comprising filling the channel at least partially to form the extended tip portion.