BIOSENSOR MEASUREMENT SYSTEM AND MEASUREMENT METHOD

• US 20100000880A1
• Filed: 07/26/2007
• Published: 01/07/2010
• Est. Priority Date: 07/26/2006
• Status: Active Grant

• Current Assignee: PHC Holdings Corporation
• Original Assignee: Panasonic Healthcare Holdings Co., Ltd.
• Inventors: Takahashi, Tsuyoshi, Itoh, Yoshihiro, Tokunaga, Hiroyuki, Yamanishi, Eriko
• Granted Patent: US 8,945,369 B2
• Time in Patent Office: Days
• US Class Current: 205/777.5
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771

Abstract

There is provided a biosensor measurement system which can output a highly-precise measurement result even when an impact such as falling of the sensor occurs or the biosensor is an exposed sensor. An abnormal waveform detection electrode is provided in addition to electrodes for quantitative determination of a target substance. Therefore, when an impact is caused by such as falling of the sensor in a halt period where no voltage is applied in a voltage application algorithm, the abnormal waveform detection electrode can detect the impact. Further, also an exposed sensor can be detected by the abnormal waveform which is detected by the abnormal waveform detection electrode.

Claims

1. A measurement method using a biosensor having a first electrode system for measuring a target substance, which comprises a working electrode and a counter electrode, and a reagent layer containing an oxidation-reduction enzyme for oxidizing or reducing the target substance, which is disposed in the vicinity of the first electrode system, said method including the steps of applying a voltage to the first electrode system after a liquid sample is introduced onto the first electrode system, detecting an oxidation-reduction current that is generated by the voltage application, and converting the current value into the quantity of the target component, wherein

said biosensor has, in addition to the first electrode system, a second electrode system for abnormality detection which comprises a working electrode and a counter electrode, and a voltage is applied to the second electrode system during the measurement period so as to detect an abnormal waveform current during the measurement period.

2. A measurement method as defined in claim 1 wherein

a voltage application pattern to the first electrode system has a halt period when no voltage is applied.

3. A measurement method as defined in claim 1 wherein

a voltage is continuously applied to the second electrode system during the measurement period.

4. A measurement method as defined in claim 1 wherein

a constant voltage is continuously applied to the second electrode system during the measurement period.

5. A measurement method as defined in claim 1 wherein

the current waveform of the second electrode system is monitored to detect an abnormal waveform.

6. A measurement method as defined in claim 5 wherein

a predetermined threshold range is set when monitoring the current waveform of the second electrode system, and the monitored waveform is judged as an abnormal waveform when the waveform is outside the threshold range.

7. A measurement method as defined in claim 6 wherein

the predetermined threshold range is set based on normal measurement response values, or it is set using differences of the response values between the respective measurement points.

8. A biosensor measurement system having a biosensor including a first electrode system for measuring a target component, which comprises a working electrode and a counter electrode, and a reagent layer containing at least an oxidation-reduction enzyme for oxidizing or reducing a specific target component, which is disposed in the vicinity of the first electrode system, said biosensor applying a voltage to the first electrode system after a liquid sample is introduced onto the first electrode system, detecting an oxidation-reduction current that is generated by the voltage application, and converting the current value into the quantity of the target component to determine the quantity of the target component,

said biosensor further including, in addition to the first electrode system, a second electrode system for abnormality detection which comprises a working electrode and a counter electrode, and said second electrode system being supplied with a voltage during the measurement period so as to detect an abnormal current during the measurement period.

9. A biosensor measurement system as defined in claim 8 wherein

the second electrode system shares its counter electrode with the first electrode system.

10. A biosensor measurement system as defined in claim 8 wherein

at least the working electrode of the second electrode system is disposed so as not to contact with the reagent layer.

11. A biosensor measurement system as defined in claim 8 wherein

at least the working electrode of the second electrode system is placed at an upper position in the stream of introducing the liquid sample than the first electrode system.

12. A biosensor measurement system as defined in claim 8 wherein

the electrodes constituting the second electrode system are also used as a sample detection electrode, a hematocrit correction electrode, or an interfering substance correction electrode other than the first electrode system.