Process For Preparing Powder Comprising Nanoparticles of Sparingly Soluble Drug
First Claim
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1. A method for preparing a powder composition comprising nanoparticles of a sparingly water-soluble drug comprising:
- 1) dispersing particles of the sparingly water-soluble drug, a surface stabilizer and a dispersion agent in a saturated aqueous solution of the dispersion agent to obtain a dispersion;
2) mixing and grinding the dispersion obtained in step
1) to obtain a homogenized dispersion; and
3) centrifuging or high-pressure filtering the homogenized dispersion obtained in step
2) to isolate a solid, and drying the solid to obtain a powder.
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Abstract
A powder comprising nanoparticles of a sparingly water-soluble drug prepared in accordance with the present invention exhibits enhanced bioavailability without generating adverse side effects caused by impurities, while the nano-particle size of the drug remains unchanged when administered. Accordingly, the powder can be useful for the development of a formulation of a sparingly water-soluble drug for oral and parenteral administration.
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18 Claims
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1. A method for preparing a powder composition comprising nanoparticles of a sparingly water-soluble drug comprising:
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1) dispersing particles of the sparingly water-soluble drug, a surface stabilizer and a dispersion agent in a saturated aqueous solution of the dispersion agent to obtain a dispersion; 2) mixing and grinding the dispersion obtained in step
1) to obtain a homogenized dispersion; and3) centrifuging or high-pressure filtering the homogenized dispersion obtained in step
2) to isolate a solid, and drying the solid to obtain a powder. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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