VESICLES OF SELF-ASSEMBLING BLOCK COPOLYMERS AND METHODS FOR MAKING AND USING THE SAME
First Claim
1. A vesicle comprising a shell encapsulating a polar fluid medium, wherein said shell comprises self-assembling block copolymers that include a first hydrophobic domain and a second hydrophilic intracellular transduction domain.
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Abstract
Vesicles of self-assembling block copolymers, e.g., diblock copolypeptides, as well as methods of making and using the same. Vesicles of the invention have a shell made up of block copolymers that include an intracellular transduction hydrophilic domain and a hydrophobic domain. In certain embodiments, the vesicles include an encapsulated active agent, e.g., a diagnostic or therapeutic agent. The vesicles find use in a variety of different application, including the intracellular delivery of active agents, e.g., diagnostic and therapeutic agents.
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Citations
43 Claims
- 1. A vesicle comprising a shell encapsulating a polar fluid medium, wherein said shell comprises self-assembling block copolymers that include a first hydrophobic domain and a second hydrophilic intracellular transduction domain.
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30. A method of treating or preventing a disease in a subject, said method comprising administering to the subject vesicle according to claim l.
- 31. A self-assembling block copolymer capable of forming a vesicle encapsulating a polar fluid medium, said self-assembling block copolymer comprising a first hydrophobic domain and a second hydrophilic intracellular transduction domain.
Specification