Novel Heterocyclic Compounds as Positive Allosteric Modulators of Metabotropic Glutamate Receptors

• US 20100004284A1
• Filed: 05/17/2006
• Published: 01/07/2010
• Est. Priority Date: 05/18/2005
• Status: Abandoned Application

• Current Assignee: Addex Pharma S.A.
• Original Assignee: Addex Pharma S.A.
• Inventors: Le Poul, Emmanuel, Gagliardi, Stefania, Farina, Marco, Rocher, Jean-Philippe, Palombi, Giovanni
• Application Number:
  US11/920,597
• Publication Number:
  US 20100004284A1
• Time in Patent Office: Days
• US Class Current: 514/318
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/14 for treating abnormal movements, e.g. chorea, dyskinesia
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives
• CPC Class Codes: A61P 25/22 Anxiolytics
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 25/32 Alcohol-abuse
• CPC Class Codes: A61P 25/34 Tobacco-abuse
• CPC Class Codes: A61P 25/36 Opioid-abuse
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 401/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 413/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 413/14 containing three or more hetero rings

Abstract

The present invention relates to new compounds which are Heterocyclic derivatives of formula (I) wherein A, B, P, X, Y, Q, W, R₁ and R₂ are defined in the description. Invention compounds are useful for treating central or peripheral nervous system disorders and other disorders which are affected by the neuromodulatory effect of mGluR5 positive allosteric modulators such as cognitive decline and also to treat both positive and negative symptoms in schizophrenia.

Claims

1. A compound of general formula I:

Wherein

W represents (C₅-C₇)cycloalkyl, (C₅-C₇)heterocycloalkyl or (C₅-C₇)heterocycloalkenyl ring;

R₁ and R₂ represent independently hydrogen, —

(C₁-C₆)alkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, arylalkyl, heteroarylalkyl, hydroxy, amino, aminoalkyl, hydroxyalkyl, —

(C₁-C₆)alkoxy or R₁ and R₂ together can form a (C₃-C₇)cycloalkyl ring, a carbonyl bond C═

O or a carbon double bond;

P and Q are each independently selected and denote a cycloalkyl, a heterocycloalkyl, an aryl or heteroaryl group of formula

R₃, R₄, R₅, R₆, and R₇ independently are hydrogen, halogen, —

CN, —

NO₂, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heteroaryl, heteroarylalkyl, arylalkyl, aryl, —

OR₈, —

NR₈R₉, —

C(═

NR₁₀)NR₈R₉, N(═

NR₁₀)NR₈R₉, —

NR₈COR₉, NR₈CO₂R₉, NR₈SO₂R₉, —

NR₁₀CONR₈R₉, —

SR₈, —

S(═

O)R₈, —

S(═

O)₂R₈, —

S(═

O)₂NR₈R₉, —

C(═

O)R₈, —

COOR₈, —

C(═

O)NR₈R₉, —

C(═

NR₈)R₉, or C(═

NOR₈)R₉ substituents;

wherein optionally two substituents are combined to the intervening atoms to form a bicyclic heterocycloalkyl, aryl or heteroaryl ring;

wherein each ring is optionally further substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆)alkyl, —

O—

(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

O—

(C₁-C₃)alkylaryl, —

O—

(C₁-C₃)alkylheteroaryl, —

N((—

C₀-C₆)alkyl)((C₀-C₃)alkylaryl) or —

N((C₀-C₆)alkyl)((C₀-C₃-)alkylheteroaryl) groups;

R₈, R₉, R₁₀ each independently is hydrogen, (C₁-C₆)alkyl, (C₃-C₆)cycloalkyl, (C₃-C₇)cycloalkylalkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆)alkyl, —

O—

(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)₂, —

N((C₀-C₆)alkyl)((C₃-C₇-)cycloalkyl) or —

N((C₀-C₆)alkyl)(aryl) substituents;

D, E, F, G and H in P and Q represent independently —

C(R₃)═

, —

C(R₃)═

C(R₄)—

, —

C(═

O)—

, —

C(═

S)—

, —

O—

, —

N═

, —

N(R₃)—

or —

S—

;

A is azo —

N═

N—

, ethyl, ethenyl, ethynyl, —

NR₈C(═

O)—

, —

NR₈S(═

O)₂—

, —

C(═

O)NR₈—

, —

S—

, —

S(═

O)—

, —

S(═

O)₂—

, —

S(═

O)₂NR₈—

, —

C(═

O)—

O—

, —

O—

C(═

O)—

, —

C(═

NR₈)NR₉—

, —

C(═

NOR₈)NR₉—

, —

NR₈C(═

NOR₉)—

, ═

N—

O—

, —

O—

N═

CH—

or a group aryl or heteroaryl of formula

R₃, R₄, R₅ and R₆ independently are as defined above;

D, E, F, G and H in A independently represent a carbon group, oxygen, nitrogen, sulphur or a double bond;

B represents a single bond, —

C(═

O)—

(C₀-C₂)alkyl-, —

C(═

O)—

(C₂-C₆)alkenyl-, —

C(═

O)—

(C₂-C₆)alkynyl-, —

C(═

O)—

O—

, —

C(═

O)NR₈—

(C₀-C₂)alkyl-, —

C(═

NR₈)NR₉—

S(═

O)—

(C₀-C₂)alkyl-, —

S(═

O)₂—

(C₀-C₂)alkyl-, —

S(═

O)₂NR₈—

(C₀-C₂)alkyl-, C(═

NR₈)—

(C₀-C₂)alkyl-, —

C(═

NOR₈)—

(C₀-C₂)alkyl- or —

C(═

NOR₈)NR₉—

(C₀-C₂)alkyl-;

R₈ and R₉, independently are as defined above;

X and Y are each independently selected from a bond, —

NR₁₁C(═

O)O—

, an optionally substituted —

(C₁-C₆)alkyl-, —

(C₂-C₆)alkynyl-, —

(C₂-C₆)alkenyl-, —

(C₃-C₇)cycloalkyl-, —

(C₃-C₈)cycloalkenyl-, —

(C₁-C₆)alkylhalo-, —

(C₁-C₆)alkylcyano-, —

(C₀-C₆)alkyl-O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-O—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-O—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₃-C₇)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₄-C₁₀)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁, —

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₃-C₇)cycloalkyl- or —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₄-C₁₀)alkylcycloalkyl;

X and Y together cannot be a bond;

R₁₁ and R₁₂ each independently is hydrogen, C₁-C₆-alkyl, C₃-C₆-cycloalkyl, C₃-C₇-cycloalkylalkyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, halo-C₁-C₆-alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, C₁-C₆-alkyl, —

O(C₀-C₆-alkyl), —

O(C₃-C₇-cycloalkylalkyl), —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)(C₀-C₆-alkyl), —

N(C₀-C₆-alkyl)(C₃-C₇-cycloalkyl) or —

N(C₀-C₆-alkyl)(aryl) substituents;

Any N may be an N-oxide;

or pharmaceutically acceptable salts, hydrates or solvates of such compounds.

2. A compound according to claim 1 having the formula I-A

Wherein

R₁ and R₂ represent independently hydrogen, — (C₁-C₆)alkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, arylalkyl, heteroarylalkyl, hydroxy, amino, aminoalkyl, hydroxyalkyl, —

(C₁-C₆)alkoxy or R₁ and R₂ together can form a (C₃-C₇)cycloalkyl ring, a carbonyl bond C═

O or a carbon double bond;

P and Q are each independently selected and denote a cycloalkyl, a heterocycloalkyl, an aryl or heteroaryl group of formula

R₃, R₄, R₅, R₆, and R₇ independently are hydrogen, halogen, —

CN, —

NO₂, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heteroaryl, heteroarylalkyl, arylalkyl, aryl, —

OR₈, —

NR₈R₉, —

C(═

NR₁₀)NR₈R₉, N(═

NR₁₀)NR₈R₉, —

NR₈COR₉, NR₈CO₂R₉, NR₈SO₂R₉, —

NR₁CONR₈R₉, —

SR₈, —

S(═

O)R₈, —

S(═

O)₂R₈, —

S(═

O)₂NR₈R₉, —

C(═

O)R₈, —

COOR₈, —

C(═

O)NR₈R₉, —

C(═

NR₈)R₉, or C(═

NOR₈)R₉ substituents;

wherein optionally two substituents are combined to the intervening atoms to form a bicyclic heterocycloalkyl, aryl or heteroaryl ring;

wherein each ring is optionally further substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆)alkyl, —

O—

(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

O—

(C₁-C₃)alkylaryl, —

O—

(C₁-C₃)alkylheteroaryl, —

N((—

CO—

C₆)alkyl)((C₀-C₃)alkylaryl) or —

N((C₀-C₆)alkyl)((C₀-C₃-)alkylheteroaryl) groups;

R₈, R₉, R₁₀ each independently is hydrogen, (C₁-C₆)alkyl, (C₃-C₆)cycloalkyl, (C₃-C₇)cycloalkylalkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆)alkyl, —

O—

(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)₂, —

N((C₀-C₆)alkyl)((C₃-C₇-)cycloalkyl) or —

N((C₀-C₆)alkyl)(aryl) substituents;

D, E, F, G and H in P and Q represent independently —

C(R₃)═

, —

C(R₃)═

C(R₄)—

, —

C(═

O)—

, —

C(═

S)—

, —

O—

, —

N═

, —

N(R₃)—

or —

S—

;

A is azo —

N═

N—

, ethyl, ethenyl, ethynyl, —

NR₈C(═

O)—

, —

NR₈S(═

O)₂—

, —

C(═

O)NR₈—

, —

S—

, —

S(═

O)—

, —

S(═

O)₂—

, —

S(═

O)₂NR₈—

, —

C(═

O)—

O—

, —

O—

C(═

O)—

, —

C(═

NR₈)NR₉—

, —

C(═

NOR₈)NR₉—

, —

NR₈C(═

NOR₉)—

, ═

N—

O—

, —

O—

N═

CH—

or a group aryl or heteroaryl of formula

R₃, R₄, R₅ and R₆ independently are as defined above;

D, E, F, G and H in A independently represent a carbon group, oxygen, nitrogen, sulphur or a double bond;

B represents a single bond, —

C(═

O)—

(C₀-C₂)alkyl-, —

C(═

O)—

(C₂-C₆)alkenyl-, —

C(═

O)—

(C₂-C₆)alkynyl-, —

C(═

O)—

O—

, —

C(═

O)NR₈—

(C₀-C₂)alkyl-, —

C(═

NR₈)NR₉—

S(═

O)—

(C₀-C₂)alkyl-, —

S(═

O)₂—

(C₀-C₂)alkyl-, —

S(═

O)₂NR₈—

(C₀-C₂)alkyl-, C(═

NR₈)—

(C₀-C₂)alkyl-, —

C(═

NOR₈)—

(C₀-C₂)alkyl- or —

C(═

NOR₈)NR₉—

(C₀-C₂)alkyl-;

R₈ and R₉, independently are as defined above;

X and Y are each independently selected from a bond, —

NR₁₁C(═

O)O—

, an optionally substituted —

(C₁-C₆)alkyl-, —

(C₂-C₆)alkynyl-, —

(C₂-C₆)alkenyl-, —

(C₃-C₇)cycloalkyl-, —

(C₃-C₈)cycloalkenyl-, —

(C₁-C₆)alkylhalo-, —

(C₁-C₆)alkylcyano-, —

(C₀-C₆)alkyl-O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-O—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-O—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₃-C₇)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₄-C₁₀)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)—

(C₂-C₆)alkenyl-, —

(C₀-C₅)alkyl-S(O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₃-C₇)cycloalkyl-, (C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₃-C₇)cycloalkyl- or —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₄-C₁₀)alkylcycloalkyl;

X and Y together cannot be a bond;

R₁₁ and R₁₂ each independently is hydrogen, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆-alkyl), —

O—

(C₃-C₇-cycloalkylalkyl), —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)(C₀-C₆-alkyl), —

N(C₀-C₆-alkyl)(C₃-C₇-cycloalkyl) or —

N(C₀-C₆-alkyl)(aryl) substituents;

J represents a single bond, —

C(R₁₃)(R₁₄), —

O—

, —

N(R₁₃)—

or —

S—

;

R₁₃, R₁₄ independently are hydrogen, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo(C₁-C₆)alkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O(C₀-C₆)alkyl, —

O(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

N((C₀-C₆)alkyl)((C₀-C₆)alkyl), —

N((C₀-C₆)alkyl)((C₃-C₇)cycloalkyl) or —

N((C₀-C₆)alkyl)(aryl) substituents;

Any N may be an N-oxide;

or pharmaceutically acceptable salts, hydrates or solvates of such compounds.

3. A compound according to claim 1 having the formula I-B

Wherein

R₁ and R₂ represent independently hydrogen, —

(C₁-C₆)alkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, arylalkyl, heteroarylalkyl, hydroxy, amino, aminoalkyl, hydroxyalkyl, —

(C₁-C₆)alkoxy or R₁ and R₂ together can form a (C₃-C₇)cycloalkyl ring, a carbonyl bond C═

O or a carbon double bond;

P and Q are each independently selected and denote a cycloalkyl, a heterocycloalkyl, an aryl or heteroaryl group of formula

R₃, R₄, R₅, R₆, and R₇ independently are hydrogen, halogen, —

CN, —

NO₂, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heteroaryl, heteroarylalkyl, arylalkyl, aryl, —

OR₈, —

NR₈R₉, —

C(═

NR₁₀)NR₈R₉, N(═

NR₁₀)NR₈R₉, —

NR₈COR₉, NR₈CO₂R₉, NR₈SO₂R₉, —

NR₁₀CONR₈R₉, —

SR₈, —

S(═

O)R₈, —

S(═

O)₂R₈, —

S(═

O)₂NR₈R₉, —

C(═

O)R₈, —

COOR₈, —

C(═

O)NR₈R₉, —

C(═

NR₈)R₉, or C(═

NOR₈)R₉ substituents;

wherein optionally two substituents are combined to the intervening atoms to form a bicyclic heterocycloalkyl, aryl or heteroaryl ring;

wherein each ring is optionally further substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆)alkyl, —

O—

(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

O—

(C₁-C₃)alkylaryl, —

O—

(C₁-C₃)alkylheteroaryl, —

N((—

C₀-C₆)alkyl)((C₀-C₃)alkylaryl) or —

N((C₀-C₆)alkyl)((C₀-C₃-)alkylheteroaryl) groups;

R₈, R₉, R₁₀ each independently is hydrogen, (C₁-C₆)alkyl, (C₃-C₆)cycloalkyl, (C₃-C₇)cycloalkylalkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆)alkyl, —

O—

(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)₂, —

N((C₀-C₆)alkyl)((C₃-C₇-)cycloalkyl) or —

N((C₀-C₆)alkyl)(aryl) substituents;

D, E, F, G and H in P and Q represent independently —

C(R₃)═

, —

C(R₃)═

C(R₄)—

, —

C(═

O)—

, —

C(═

S)—

, —

O—

, —

N═

, —

N(R₃)—

or —

S—

;

B represents a single bond, —

C(═

O)—

(C₀-C₂)alkyl-, —

C(═

O)—

(C₂-C₆)alkenyl-, —

C(═

O)—

(C₂-C₆)alkynyl-, —

C(═

O)—

O—

, —

C(═

O)NR₈—

(C₀-C₂)alkyl-, —

C(═

NR₈)NR₉—

S(═

O)—

(C₀-C₂)alkyl-, —

S(═

O)₂—

(C₀-C₂)alkyl-, —

S(═

O)₂NR₈—

(C₀-C₂)alkyl-, C(═

NR₈)—

(C₀-C₂)alkyl-, —

C(═

NOR₈)—

(C₀-C₂)alkyl- or —

C(═

NOR₈)NR₉—

(C₀-C₂)alkyl-;

R₈ and R₉, independently are as defined above;

X and Y are each independently selected from a bond, —

NR₁₁C(═

O)O—

, an optionally substituted —

(C₁-C₆)alkyl-, —

(C₂-C₆)alkynyl-, —

(C₂-C₆)alkenyl-, —

(C₃-C₇)cycloalkyl-, —

(C₃-C₈)cycloalkenyl-, —

(C₁-C₆)alkylhalo-, —

(C₁-C₆)alkylcyano-, —

(C₀-C₆)alkyl-O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-O—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-O—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₃-C₇)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₄-C₁₀)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁, C(═

O)O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₃-C₇)cycloalkyl- or —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₄-C₁₀)alkylcycloalkyl;

X and Y together cannot be a bond;

R₁₁ and R₁₂ each independently is hydrogen, C₁-C₆-alkyl, C₃-C₆-cycloalkyl, C₃-C₇-cycloalkylalkyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, halo-C₁-C₆-alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, C₁-C₆-alkyl, —

O(C₀-C₆-alkyl), —

O(C₃-C₇-cycloalkylalkyl), —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)(C₀-C₆-alkyl), —

N(C₀-C₆-alkyl)(C₃-C₇-cycloalkyl) or —

N(C₀-C₆-alkyl)(aryl) substituents;

J represents a single bond, —

C(R₁₃)(R₁₄), —

O—

, —

N(R₁₃)—

or —

S—

;

R₁₃, R₁₄ independently are hydrogen, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo(C₁-C₆)alkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O(C₀-C₆)alkyl, —

O(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

N((C₀-C₆)alkyl)((C₀-C₆)alkyl), —

N((C₀-C₆)alkyl)((C₃-C₇)cycloalkyl) or —

N((C₀-C₆)alkyl)(aryl) substituents;

Any N may be an N-oxide;

or pharmaceutically acceptable salts, hydrates or solvates of such compounds.

4. A compound according to claim 1 having the formula I-C

Wherein

R₁ and R₂ represent independently hydrogen, —

(C₁-C₆)alkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, arylalkyl, heteroarylalkyl, hydroxy, amino, aminoalkyl, hydroxyalkyl, —

(C₁-C₆)alkoxy or R₁ and R₂ together can form a (C₃-C₇)cycloalkyl ring, a carbonyl bond C═

O or a carbon double bond;

P and Q are each independently selected and denote a cycloalkyl, a heterocycloalkyl, an aryl or heteroaryl group of formula

R₃, R₄, R₅, R₆, and R₇ independently are hydrogen, halogen, —

CN, —

NO₂, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heteroaryl, heteroarylalkyl, arylalkyl, aryl, —

OR₈, —

NR₈R₉, —

C(═

NR₁₀)NR₈R₉, N(═

NR₁₀)NR₈R₉, —

NR₈COR₉, NR₈CO₂R₉, NR₈SO₂R₉, —

NR₁₀CONR₈R₉, —

SR₈, —

S(═

O)R₈, —

S(═

O)₂R₈, —

S(═

O)₂NR₈R₉, —

C(═

O)R₈, —

COOR₈, —

C(═

O)NR₈R₉, —

C(═

NR₈)R₉, or C(═

NOR₈)R₉ substituents;

wherein optionally two substituents are combined to the intervening atoms to form a bicyclic heterocycloalkyl, aryl or heteroaryl ring;

wherein each ring is optionally further substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆)alkyl, —

O—

(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

O—

(C₁-C₃)alkylaryl, —

O—

(C₁-C₃)alkylheteroaryl, —

N((—

C₀-C₆)alkyl)((C₀-C₃)alkylaryl) or —

N((C₀-C₆)alkyl)((C₀-C₃-)alkylheteroaryl) groups;

R₈, R₉, R₁₀ each independently is hydrogen, (C₁-C₆)alkyl, (C₃-C₆)cycloalkyl, (C₃-C₇)cycloalkylalkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆)alkyl, —

O—

(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)₂, —

N((C₀-C₆)alkyl)((C₃-C₇-)cycloalkyl) or —

N((C₀-C₆)alkyl)(aryl) substituents;

D, E, F, G and H in P and Q represent independently —

C(R₃)═

, —

C(R₃)═

C(R₄)—

, —

C(═

O)—

, —

C(═

S)—

, —

O—

, —

N═

, —

N(R₃)—

or —

S—

;

B represents a single bond, —

C(═

O)—

(C₀-C₂)alkyl-, —

C(═

O)—

(C₂-C₆)alkenyl-, —

C(═

O)—

(C₂-C₆)alkynyl-, —

C(═

O)—

O—

, —

C(═

O)NR₈—

(C₀-C₂)alkyl-, —

C(═

NR₈)NR₉—

S(═

O)—

(C₀-C₂)alkyl-, —

S(═

O)₂—

(C₀-C₂)alkyl-, —

S(═

O)₂NR₈—

(C₀-C₂)alkyl-, C(═

NR₈)—

(C₀-C₂)alkyl-, —

C(═

NOR₈)—

(C₀-C₂)alkyl- or —

C(═

NOR₈)NR₉—

(C₀-C₂)alkyl-;

R₈ and R₉, independently are as defined above;

X and Y are each independently selected from a bond, —

NR₁₁C(═

O)O—

, an optionally substituted —

(C₁-C₆)alkyl-, —

(C₂-C₆)alkynyl-, —

(C₂-C₆)alkenyl-, —

(C₃-C₇)cycloalkyl-, —

(C₃-C₈)cycloalkenyl-, —

(C₁-C₆)alkylhalo-, —

(C₁-C₆)alkylcyano-, —

(C₀-C₆)alkyl-O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-O—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-O—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₃-C₇)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₄-C₁₀)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₃-C₇)cycloalkyl- or —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₄-C₁₀)alkylcycloalkyl

X and Y together cannot be a bond;

R₁₁ and R₁₂ each independently is hydrogen, C₁-C₆-alkyl, C₃-C₆-cycloalkyl, C₃-C₇-cycloalkylalkyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, halo-C₁-C₆-alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, C₁-C₆-alkyl —

O(C₀-C₆-alkyl), —

O(C₃-C₇-cycloalkylalkyl), —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)(C₀-C₆-alkyl), —

N(C₀-C₆-alkyl)(C₃-C₇-cycloalkyl) or —

N(C₀-C₆-alkyl)(aryl) substituents;

J represents a single bond, —

C(R₁₃)(R₁₄), —

O—

, —

N(R₁₃)—

or —

S—

;

R₁₃, R₁₄ independently are hydrogen, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo(C₁-C₆)alkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O(C₀-C₆)alkyl, —

O(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

N((C₀-C₆)alkyl)((C₀-C₆)alkyl), —

N((C₀-C₆)alkyl)((C₃-C₇)cycloalkyl) or —

N((C₀-C₆)alkyl)(aryl) substituents;

Any N may be an N-oxide;

or pharmaceutically acceptable salts, hydrates or solvates of such compounds.

5. A compound according to claim 1 shaving the formula I-D

Wherein

P and Q are each independently selected and denote a cycloalkyl, a heterocycloalkyl, an aryl or heteroaryl group of formula

R₃, R₄, R₅, R₆, and R₇ independently are hydrogen, halogen, —

CN, —

NO₂, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heteroaryl, heteroarylalkyl, arylalkyl, aryl, —

OR₈, —

NR₈R₉, —

C(═

NR₁₀)NR₈R₉, N(═

NR₁₀)NR₈R₉, —

NR₈COR₉, NR₈CO₂R₉, NR₈SO₂R₉, —

NR₁₀CONR₈R₉, —

SR₈, —

S(═

O)R₈, —

S(═

O)₂R₈, —

S(═

O)₂NR₈R₉, —

C(═

O)R₈, —

COOR₈, —

C(═

O)NR₈R₉, —

C(═

NR₈)R₉, or C(═

NOR₈)R₉ substituents;

wherein optionally two substituents are combined to the intervening atoms to form a bicyclic heterocycloalkyl, aryl or heteroaryl ring;

wherein each ring is optionally further substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆)alkyl, —

O—

(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

O—

(C₁-C₃)alkylaryl, —

O—

(C₁-C₃)alkylheteroaryl, —

N((—

C₀-C₆)alkyl)((C₀-C₃)alkylaryl) or —

N((C₀-C₆)alkyl)((C₀-C₃-)alkylheteroaryl) groups;

R₈, R₉, R₁₀ each independently is hydrogen, (C₁-C₆)alkyl, (C₃-C₆)cycloalkyl, (C₃-C₇)cycloalkylalkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆)alkyl, —

O—

(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)₂, —

N((C₀-C₆)alkyl)((C₃-C₇-)cycloalkyl) or —

N((C₀-C₆)alkyl)(aryl) substituents;

D, E, F, G and H in P and Q represent independently —

C(R₃)═

, —

C(R₃)═

C(R₄)—

, —

C(═

O)—

, —

C(═

S)—

, —

O—

, —

N═

, —

N(R₃)—

or —

S—

;

B represents a single bond, —

C(═

O)—

(C₀-C₂)alkyl-, —

C(═

O)—

(C₂-C₆)alkenyl-, —

C(═

O)—

(C₂-C₆)alkynyl-, —

C(═

O)—

O—

, —

C(═

O)NR₈—

(C₀-C₂)alkyl-, —

C(═

NR₈)NR₉—

S(═

O)—

(C₀-C₂)alkyl-, —

S(═

O)₂—

(C₀-C₂)alkyl-, —

S(═

O)₂NR₈—

(C₀-C₂)alkyl-, C(═

NR₈)—

(C₀-C₂)alkyl-, —

C(═

NOR₈)—

(C₀-C₂)alkyl- or —

C(═

NOR₈)NR₉—

(C₀-C₂)alkyl-;

R₈ and R₉, independently are as defined above;

X represents —

NR₁₁C(═

O)O—

, an optionally substituted —

(C₁-C₆)alkyl-, —

(C₂-C₆)alkynyl-, —

(C₂-C₆)alkenyl-, —

(C₃-C₇)cycloalkyl-, —

(C₃-C₈)cycloalkenyl-, —

(C₁-C₆)alkylhalo-, —

(C₁-C₆)alkylcyano-, —

(C₀-C₆)alkyl-O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-O—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-O—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₃-C₇)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₄-C₁₀)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₀-C₆)alkyl-, (C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR¹¹C(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁, —

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₃-C₇)cycloalkyl- or —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₄-C₁₀)alkylcycloalkyl;

R₁₁ and R₁₂ each independently is hydrogen, C₁-C₆-alkyl, C₃-C₆-cycloalkyl, C₃-C₇-cycloalkylalkyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, halo-C₁-C₆-alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, C₁-C₆-alkyl —

O(C₀-C₆-alkyl), —

O(C₃-C₇-cycloalkylalkyl), —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)(C₀-C₆-alkyl), —

N(C₀-C₆-alkyl)(C₃-C₇-cycloalkyl) or —

N(C₀-C₆-alkyl)(aryl) substituents;

J represents a single bond, —

C(R₁₃)(R₁₄), —

O—

, —

N(R₁₃)—

or —

S—

;

R₁₃, R₁₄ independently are hydrogen, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo(C₁-C₆)alkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O(C₀-C₆)alkyl, —

O(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

N((C₀-C₆)alkyl)((C₀-C₆)alkyl), —

N((C₀-C₆)alkyl)((C₃-C₇)cycloalkyl) or —

N((C₀-C₆)alkyl)(aryl) substituents;

Any N may be an N-oxide;

or pharmaceutically acceptable salts, hydrates or solvates of such compounds.

6. A compound according to claim 5 having the formula I-D

Wherein

X represents an optionally substituted —

(C₁-C₆)alkyl-, —

(C₂-C₆)alkynyl-, —

(C₂-C₆)alkenyl-, —

(C₃-C₇)cycloalkyl-, —

(C₃-C₈)cycloalkenyl-, —

(C₁-C₆)alkylhalo-, —

(C₁-C₆)alkylcyano-, —

(C₀-C₆)alkyl-O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-O—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-O—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₃-C₇)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₄-C₁₀)cycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₃-C₇)cycloalkyl- or (C₀-C₆)alkyl-NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-;

R₁₁ is hydrogen, C₁-C₆-alkyl, C₃-C₆-cycloalkyl, C₃-C₇-cycloalkylalkyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, halo-C₁-C₆-alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, C₁-C₆ alkyl, —

O(C₀-C₆-alkyl), —

O(C₃-C₇-cycloalkylalkyl), —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)(C₀-C₆-alkyl), —

N(C₀-C₆-alkyl)(C₃-C₇-cycloalkyl) or —

N(C₀-C₆-alkyl)(aryl) substituents;

Any N may be an N-oxide;

or pharmaceutically acceptable salts, hydrates or solvates of such compounds.

7. A compound according to claim 1 having the formula II-A

Wherein

R₁ and R₂ represent independently hydrogen, —

(C₁-C₆)alkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, arylalkyl, heteroarylalkyl, hydroxy, amino, aminoalkyl, hydroxyalkyl, —

(C₁-C₆)alkoxy or R₁ and R₂ together can form a (C₃-C₇)cycloalkyl ring, a carbonyl bond C═

O or a carbon double bond;

P and Q are each independently selected and denote a cycloalkyl, a heterocycloalkyl, an aryl or heteroaryl group of formula

R₃, R₄, R₅, R₆, and R₇ independently are hydrogen, halogen, —

CN, —

NO₂, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heteroaryl, heteroarylalkyl, arylalkyl, aryl, —

OR₈, —

NR₈R₉, —

C(═

NR₁₀)NR₈R₉, N(═

NR₁₀)NR₈R₉, —

NR₈COR₉, NR₈CO₂R₉, NR₈SO₂R₉, —

NR₁₀CONR₈R₉, —

SR₈, —

S(═

O)R₈, —

S(═

O)₂R₈, —

S(═

O)₂NR₈R₉, —

C(═

O)R₈, —

COOR₈, —

C(═

O)NR₈R₉, —

C(═

NR₈)R₉, or C(═

NOR₈)R₉ substituents;

wherein optionally two substituents are combined to the intervening atoms to form a bicyclic heterocycloalkyl, aryl or heteroaryl ring;

wherein each ring is optionally further substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆)alkyl, —

O—

(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

O—

(C₁-C₃)alkylaryl, —

O—

(C₁-C₃)alkylheteroaryl, —

N((—

C₀-C₆)alkyl)((C₀-C₃)alkylaryl) or —

N((C₀-C₆)alkyl)((C₀-C₃-)alkylheteroaryl) groups;

R₈, R₉, R₁₀ each independently is hydrogen, (C₁-C₆)alkyl, (C₃-C₆)cycloalkyl, (C₃-C₇)cycloalkylalkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆)alkyl, —

O—

(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)₂, —

N((C₀-C₆)alkyl)((C₃-C₇-)cycloalkyl) or —

N((C₀-C₆)alkyl)(aryl) substituents;

D, E, F, G and H in P and Q represent independently —

C(R₃)═

, —

C(R₃)═

C(R₄)—

, —

C(═

O)—

, —

C(═

S)—

, —

O—

, —

N═

, —

N(R₃)—

or —

S—

;

B represents a single bond, —

C(═

O)—

(C₀-C₂)alkyl-, —

C(═

O)—

(C₂-C₆)alkenyl-, —

C(═

O)—

(C₂-C₆)alkynyl-, —

C(═

O)—

O—

, —

C(═

O)NR₈—

(C₀-C₂)alkyl-, —

C(═

NR₈)NR₉—

S(═

O)—

(C₀-C₂)alkyl-, —

S(═

O)₂—

(C₀-C₂)alkyl-, —

S(═

O)₂NR₈—

(C₀-C₂)alkyl-, C(═

NR₈)—

(C₀-C₂)alkyl-, —

C(═

NOR₈)—

(C₀-C₂)alkyl- or —

C(═

NOR₈)NR₉—

(C₀-C₂)alkyl-;

R₈ and R₉, independently are as defined above;

X and Y are each independently selected from a bond, —

NR₁₁C(═

O)O—

, an optionally substituted —

(C₁-C₆)alkyl-, —

(C₂-C₆)alkynyl-, —

(C₂-C₆)alkenyl-, —

(C₃-C₇)cycloalkyl-, —

(C₃-C₈)cycloalkenyl-, —

(C₁-C₆)alkylhalo-, —

(C₁-C₆)alkylcyano-, —

(C₀-C₆)alkyl-O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-O—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-O—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₃-C₇)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₄-C₁₀)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₀-C₆)alkyl-, (C₀-C₆)alkyl-C(═

O)O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁, —

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₁-C₆)alkyl-OC(═

O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₃-C₇)cycloalkyl- or —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₄-C₁₀)alkylcycloalkyl;

X and Y together cannot be a bond;

R₁₁ and R₁₂ each independently is hydrogen, C₁-C₆-alkyl, C₃-C₆-cycloalkyl, C₃-C₇-cycloalkylalkyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, halo-C₁-C₆-alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, C₁-C₆-alkyl, —

O(C₀-C₆-alkyl), —

O(C₃-C₇-cycloalkylalkyl), —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)(C₀-C₆-alkyl), —

N(C₀-C₆-alkyl)(C₃-C₇-cycloalkyl) or —

N(C₀-C₆-alkyl)(aryl) substituents;

J represents a single bond, —

C(R₁₃)(R₁₄), —

O—

, —

N(R₁₃)—

or —

S—

;

R₁₃, R₁₄ independently are hydrogen, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo(C₁-C₆)alkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O(C₀-C₆)alkyl, —

O(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

N((C₀-C₆)alkyl)((C₀-C₆)alkyl), —

N((C₀-C₆)alkyl)((C₃-C₇)cycloalkyl) or —

N((C₀-C₆)alkyl)(aryl) substituents;

Any N may be an N-oxide;

or pharmaceutically acceptable salts, hydrates or solvates of such compounds.

8. A compound according to claim 1 having the formula II-B

Wherein

P and Q are each independently selected and denote a cycloalkyl, a heterocycloalkyl, an aryl or heteroaryl group of formula

R₃, R₄, R₅, R₆, and R₇ independently are hydrogen, halogen, —

CN, —

NO₂, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heteroaryl, heteroarylalkyl, arylalkyl, aryl, —

OR₈, —

NR₈R₉, —

C(═

NR₁₀)NR₈R₉, N(═

NR₁₀)NR₈R₉, —

NR₈COR₉, NR₈CO₂R₉, NR₈SO₂R₉, —

NR₁₀CONR₈R₉, —

SR₈, —

S(═

O)R₈, —

S(═

O)₂R₈, —

S(═

O)₂NR₈R₉, —

C(═

O)R₈, —

COOR₈, —

C(═

O)NR₈R₉, —

C(═

NR₈)R₉, or C(═

NOR₈)R₉ substituents;

wherein optionally two substituents are combined to the intervening atoms to form a bicyclic heterocycloalkyl, aryl or heteroaryl ring;

wherein each ring is optionally further substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆)alkyl, —

O—

(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

O—

(C₁-C₃)alkylaryl, —

O—

(C₁-C₃)alkylheteroaryl, —

N((—

C₀-C₆)alkyl)((C₀-C₃)alkylaryl) or —

N((C₀-C₆)alkyl)((C₀-C₃-)alkylheteroaryl) groups;

R₈, R₉, R₁₀ each independently is hydrogen, (C₁-C₆)alkyl, (C₃-C₆)cycloalkyl, (C₃-C₇)cycloalkylalkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆)alkyl, —

O—

(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)₂, —

N((C₀-C₆)alkyl)((C₃-C₇-)cycloalkyl) or —

N((C₀-C₆)alkyl)(aryl) substituents;

D, E, F, G and H in P and Q represent independently —

C(R₃)═

, —

C(R₃)═

C(R₄)—

, —

C(═

O)—

, —

C(═

S)—

, —

O—

, —

N═

, —

N(R₃)—

or —

S—

;

B represents a single bond, —

C(═

O)—

(C₀-C₂)alkyl-, —

C(═

O)—

(C₂-C₆)alkenyl-, —

C(═

O)—

(C₂-C₆)alkynyl-, —

C(═

O)—

O—

, —

C(═

O)NR₈—

(C₀-C₂)alkyl-, —

C(═

NR₈)NR₉—

S(═

O)—

(C₀-C₂)alkyl-, —

S(═

O)₂—

(C₀-C₂)alkyl-, —

S(═

O)₂NR₈—

(C₀-C₂)alkyl-, C(═

NR₈)—

(C₀-C₂)alkyl-, —

C(═

NOR₈)—

(C₀-C₂)alkyl- or —

C(═

NOR₈)NR₉—

(C₀-C₂)alkyl-;

R₈ and R₉, independently are as defined above;

X represents —

NR₁₁C(═

O)O—

, an optionally substituted —

(C₁-C₆)alkyl-, —

(C₂-C₆)alkynyl-, —

(C₂-C₆)alkenyl-, —

(C₃-C₇)cycloalkyl-, —

(C₃-C₈)cycloalkenyl-, —

(C₁-C₆)alkylhalo-, —

(C₁-C₆)alkylcyano-, —

(C₀-C₆)alkyl-O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-O—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-O—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₃-C₇)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₄-C₁₀)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)O—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)NR₁, —

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR¹¹C(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

O)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁S(O)₂—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁, —

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₂C(═

S)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-OC(═

O)NR₁₁—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁, C(═

O)O—

(C₃-C₇)cycloalkyl- or —

(C₀-C₆)alkyl-NR₁₁C(═

O)O—

(C₄-C₁₀)alkylcycloalkyl;

R₁₁ and R₁₂ each independently is hydrogen, C₁-C₆-alkyl, C₃-C₆-cycloalkyl, C₃-C₇-cycloalkylalkyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, halo-C₁-C₆-alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, C₁-C₆-alkyl, —

O(C₀-C₆-alkyl), —

O(C₃-C₇-cycloalkylalkyl), —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)(C₀-C₆-alkyl), —

N(C₀-C₆-alkyl)(C₃-C₇-cycloalkyl) or —

N(C₀-C₆-alkyl)(aryl) substituents;

J represents a single bond, —

C(R₁₃)(R₁₄), —

O—

, —

N(R₁₃)—

or —

S—

;

R₁₃, R₁₄ independently are hydrogen, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo(C₁-C₆)alkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O(C₀-C₆)alkyl, —

O(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

N((C₀-C₆)alkyl)((C₀-C₆)alkyl), —

N((C₀-C₆)alkyl)((C₃-C₇)cycloalkyl) or —

N((C₀-C₆)alkyl)(aryl) substituents;

Any N may be an N-oxide;

or pharmaceutically acceptable salts, hydrates or solvates of such compounds.

9. A compound according to claim 1 shaving the formula II-B

Wherein

X represents an optionally substituted —

(C₁-C₆)alkyl-, —

(C₂-C₆)alkynyl-, —

(C₂-C₆)alkenyl-, —

(C₃-C₇)cycloalkyl-, —

(C₃-C₈)cycloalkenyl-, —

(C₁-C₆)alkylhalo-, —

(C₁-C₆)alkylcyano-, —

(C₀-C₆)alkyl-O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-O—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-O—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₃-C₇)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₄-C₁₀)cycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁, —

(C₃-C₇)cycloalkyl- or —

(C₀-C₆)alkyl-NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-;

R₁₁ is hydrogen, C₁-C₆-alkyl, C₃-C₆-cycloalkyl, C₃-C₇-cycloalkylalkyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, halo-C₁-C₆-alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, C₁-C₆-alkyl, —

O(C₀-C₆-alkyl), —

O(C₃-C₇-cycloalkylalkyl), —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)(C₀-C₆-alkyl), —

N(C₀-C₆-alkyl)(C₃-C₇-cycloalkyl) or —

N(C₀-C₆-alkyl)(aryl) substituents;

Any N may be an N-oxide;

or pharmaceutically acceptable salts, hydrates or solvates of such compounds.

10. A compound according to claim 1 shaving the formula III-A

Wherein

P and Q are each independently selected and denote a cycloalkyl, a heterocycloalkyl, an aryl or heteroaryl group of formula

R₃, R₄, R₅, R₆, and R₇ independently are hydrogen, halogen, —

CN, —

NO₂, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heteroaryl, heteroarylalkyl, arylalkyl, aryl, —

OR₈, —

NR₈R₉, —

C(═

NR₁₀)NR₈R₉, N(═

NR₁₀)NR₈R₉, —

NR₈COR₉, NR₈CO₂R₉, NR₈SO₂R₉, —

NR₁₀CONR₈R₉, —

SR₈, —

S(═

O)R₈, —

S(═

O)₂R₈, —

S(═

O)₂NR₈R₉, —

C(═

O)R₈, —

COOR₈, —

C(═

O)NR₈R₉, —

C(═

NR₈)R₉, or C(═

NOR₈)R₉ substituents;

wherein optionally two substituents are combined to the intervening atoms to form a bicyclic heterocycloalkyl, aryl or heteroaryl ring;

wherein each ring is optionally further substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆)alkyl, —

O—

(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

O—

(C₁-C₃)alkylaryl, —

O—

(C₁-C₃)alkylheteroaryl, —

N((—

C₀-C₆)alkyl)((C₀-C₃)alkylaryl) or —

N((C₀-C₆)alkyl)((C₀-C₃-)alkylheteroaryl) groups;

R₈, R₉, R₁₀ each independently is hydrogen, (C₁-C₆)alkyl, (C₃-C₆)cycloalkyl, (C₃-C₇)cycloalkylalkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆)alkyl, —

O—

(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)₂, —

N((C₀-C₆)alkyl)((C₃-C₇-)cycloalkyl) or —

N((C₀-C₆)alkyl)(aryl) substituents;

D, E, F, G and H in P and Q represent independently —

C(R₃)═

, —

C(R₃)═

C(R₄)—

, —

C(═

O)—

, —

C(═

S)—

, —

O—

, —

N═

, —

N(R₃)—

or —

S—

;

B represents a single bond, —

C(═

O)—

(C₀-C₂)alkyl-, —

C(═

O)—

(C₂-C₆)alkenyl-, —

C(═

O)—

(C₂-C₆)alkynyl-, —

C(═

O)—

O—

, —

C(═

O)NR₈—

(C₀-C₂)alkyl-, —

C(═

NR₈)NR₉—

S(═

O)—

(C₀-C₂)alkyl-, —

S(═

O)₂—

(C₀-C₂)alkyl-, —

S(═

O)₂NR₈—

(C₀-C₂)alkyl-, C(═

NR₈)—

(C₀-C₂)alkyl-, —

C(═

NOR₈)—

(C₀-C₂)alkyl- or —

C(═

NOR₈)NR₉—

(C₀-C₂)alkyl-;

R₈ and R₉, independently are as defined above;

X represents an optionally substituted —

(C₁-C₆)alkyl-, —

(C₂-C₆)alkynyl-, —

(C₂-C₆)alkenyl-, —

(C₃-C₇)cycloalkyl-, —

(C₃-C₈)cycloalkenyl-, —

(C₁-C₆)alkylhalo-, —

(C₁-C₆)alkylcyano-, —

(C₀-C₆)alkyl-O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-O—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-O—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₃-C₇)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₄-C₁₀)cycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₃-C₇)cycloalkyl- or —

(C₀-C₆)alkyl-NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-;

R₁₁ and R₁₂ each independently is hydrogen, C₁-C₆-alkyl, C₃-C₆-cycloalkyl, C₃-C₇-cycloalkylalkyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, halo-C₁-C₆-alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, C₁-C₆-alkyl, —

O(C₀-C₆-alkyl), —

O(C₃-C₇-cycloalkylalkyl), —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)(C₀-C₆-alkyl), —

N(C₀-C₆-alkyl)(C₃-C₇-cycloalkyl) or —

N(C₀-C₆-alkyl)(aryl) substituents;

J represents a single bond, —

C(R₁₃)(R₁₄), —

O—

, —

N(R₁₃)—

or —

S—

;

R₁₃, R₁₄ independently are hydrogen, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo(C₁-C₆)alkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O(C₀-C₆)alkyl, —

O(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

N((C₀-C₆)alkyl)((C₀-C₆)alkyl), —

N((C₀-C₆)alkyl)((C₃-C₇)cycloalkyl) or —

N((C₀-C₆)alkyl)(aryl) substituents;

Any N may be an N-oxide;

or pharmaceutically acceptable salts, hydrates or solvates of such compounds.

11. A compound according to claim 1 having the formula IV-A

Wherein

P and Q are each independently selected and denote a cycloalkyl, a heterocycloalkyl, an aryl or heteroaryl group of formula

R₃, R₄, R₅, R₆, and R₇ independently are hydrogen, halogen, —

CN, —

NO₂, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heteroaryl, heteroarylalkyl, arylalkyl, aryl, —

OR₈, —

NR₈R₉, —

C(═

NR₁₀)NR₈R₉, N(═

NR₁₀)NR₈R₉, —

NR₈COR₉, NR₈CO₂R₉, NR₈SO₂R₉, —

NR₁₀CONR₈R₉, —

SR₈, —

S(═

O)R₈, —

S(═

O)₂R₈, —

S(═

O)₂NR₈R₉, —

C(═

O)R₈, —

COOR₈, —

C(═

O)NR₈R₉, —

C(═

NR₈)R₉, or C(═

NOR₈)R₉ substituents;

wherein optionally two substituents are combined to the intervening atoms to form a bicyclic heterocycloalkyl, aryl or heteroaryl ring;

wherein each ring is optionally further substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆)alkyl, —

O—

(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

O—

(C₁-C₃)alkylaryl, —

O—

(C₁-C₃)alkylheteroaryl, —

N((—

C₀-C₆)alkyl)((C₀-C₃)alkylaryl) or —

N((C₀-C₆)alkyl)((C₀-C₃-)alkylheteroaryl) groups;

R₈, R₉, R₁₀ each independently is hydrogen, (C₁-C₆)alkyl, (C₃-C₆)cycloalkyl, (C₃-C₇)cycloalkylalkyl, (C₂-C₆)alkenyl, (C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O—

(C₀-C₆)alkyl, —

O—

(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)₂, —

N((C₀-C₆)alkyl)((C₃-C₇-)cycloalkyl) or —

N((C₀-C₆)alkyl)(aryl) substituents;

D, E, F, G and H in P and Q represent independently —

C(R₃)═

, —

C(R₃)═

C(R₄)—

, —

C(═

O)—

, —

C(═

S)—

, —

O—

, —

N═

, —

N(R₃)—

or —

S—

;

B represents a single bond, —

C(═

O)—

(C₀-C₂)alkyl-, —

C(═

O)—

(C₂-C₆)alkenyl-, —

C(═

O)—

(C₂-C₆)alkynyl-, —

C(═

O)—

O—

, —

C(═

O)NR₈—

(C₀-C₂)alkyl-, —

C(═

NR₈)NR₉—

S(═

O)—

(C₀-C₂)alkyl-, —

S(═

O)₂—

(C₀-C₂)alkyl-, —

S(═

O)₂NR₈—

(C₀-C₂)alkyl-, C(═

NR₈)—

(C₀-C₂)alkyl-, —

C(═

NOR₈)—

(C₀-C₂)alkyl- or —

C(═

NOR₈)NR₉—

(C₀-C₂)alkyl-;

R₈ and R₉, independently are as defined above;

X represents an optionally substituted —

(C₁-C₆)alkyl-, —

(C₂-C₆)alkynyl-, —

(C₂-C₆)alkenyl-, —

(C₃-C₇)cycloalkyl-, —

(C₃-C₈)cycloalkenyl-, —

(C₁-C₆)alkylhalo-, —

(C₁-C₆)alkylcyano-, —

(C₀-C₆)alkyl-O—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-O—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-O—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₃-C₇)alkylcycloalkyl-, —

(C₀-C₆)alkyl-C(═

O)—

(C₄-C₁₀)cycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-O—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₃-C₇)cycloalkyl-, —

(C₀-C₆)alkyl-S(O)₂—

(C₄-C₁₀)alkylcycloalkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₀-C₆)alkyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkynyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₂-C₆)alkenyl-, —

(C₀-C₆)alkyl-NR₁₁—

(C₃-C₇)cycloalkyl- or —

(C₀-C₆)alkyl-NR₁₁—

(C₄-C₁₀)alkylcycloalkyl-;

R₁₁ and R₁₂ each independently is hydrogen, C₁-C₆-alkyl, C₃-C₆-cycloalkyl, C₃-C₇-cycloalkylalkyl, C₂-C₆-alkenyl, C₂-C₆-alkynyl, halo-C₁-C₆-alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, C₁-C₆-alkyl, —

O(C₀-C₆-alkyl), —

O(C₃-C₇-cycloalkylalkyl), —

O(aryl), —

O(heteroaryl), —

N(C₀-C₆-alkyl)(C₀-C₆-alkyl), —

N(C₀-C₆-alkyl)(C₃-C₇-cycloalkyl) or —

N(C₀-C₆-alkyl)(aryl) substituents;

J represents a single bond, —

C(R₁₃)(R₁₄), —

O—

, —

N(R₁₃)—

or —

S—

;

R₁₃, R₁₄ independently are hydrogen, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo(C₁-C₆)alkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₈)alkyl, —

O(C₀-C₆)alkyl, —

O(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

N((C₀-C₆)alkyl)((C₀-C₆)alkyl), —

N((C₀-C₆)alkyl)((C₃-C₇)cycloalkyl) or —

N((C₀-C₆)alkyl)(aryl) substituents;

R₁₅ is hydrogen, —

(C₁-C₆)alkyl, —

(C₃-C₆)cycloalkyl, —

(C₃-C₇)cycloalkylalkyl, —

(C₂-C₆)alkenyl, —

(C₂-C₆)alkynyl, halo-(C₁-C₆)alkyl, heterocycloalkyl, heteroaryl, heteroarylalkyl, arylalkyl or aryl;

any of which is optionally substituted with 1-5 independent halogen, —

CN, —

(C₁-C₆)alkyl, —

O(C₀-C₆)alkyl, —

O(C₃-C₇)cycloalkylalkyl, —

O(aryl), —

O(heteroaryl), —

N((C₀-C₆)alkyl)((C₀-C₆)alkyl, —

N((C₀-C₆)alkyl)((C₃-C₇)cycloalkyl) or —

N((C₀-C₆)alkyl)(aryl) substituents;

Any N may be an N-oxide;

or pharmaceutically acceptable salts, hydrates or solvates of such compounds.

12. A compound according to claim 1, which can exist as optical isomers, wherein said compound is either the racemic mixture or an individual optical isomer.

13. A compound according to claim 1, wherein said compound is selected from:

{(S)-3-[3-(4-Fluoro-benzyl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone,

(3,4-Difluoro-phenyl)-{(S)-3-[3-(4-fluoro-benzyl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-methanone

(3,4-Difluoro-phenyl)-{(S)-3-[5-(4-fluoro-benzyl)-[1,2,4]oxadiazol-3-yl]-piperidin-1-yl}-methanone

{(S)-3-[5-(4-Fluoro-benzyl)-[1,2,4]oxadiazol-3-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone

(4-Fluoro-phenyl)-{(S)-3-[5-((S)-1-phenyl-ethyl)-[1,2,4]oxadiazol-3-yl]-piperidin-1-yl}-methanone

(4-Fluoro-phenyl)-{(S)-3-[5-((R)-1-phenyl-ethyl)-[1,2,4]oxadiazol-3-yl]-piperidin-1-yl}-methanone

[(S)-3-(5-Benzyl-[1,2,4]oxadiazol-3-yl)-piperidin-1-yl]-(4-fluoro-phenyl)-methanone

(4-Fluoro-phenyl)-{(S)-3-[5-((S)-hydroxy-phenyl-methyl)-[1,2,4]oxadiazol-3-yl]-piperidin-1-yl}-methanone

(4-Fluoro-phenyl)-{(S)-3-[5-((R)-hydroxy-phenyl-methyl)-[1,2,4]oxadiazol-3-yl]-piperidin-1-yl}-methanone

(4-Fluoro-phenyl)-[(S)-3-(5-phenethyl-[1,2,4]oxadiazol-3-yl)-piperidin-1-yl]-methanone

{3-[(S)-1-(4-Fluoro-benzoyl)-piperidin-3-yl]-[1,2,4]oxadiazol-5-yl}-phenyl-methanone

(4-Fluoro-phenyl)-[(S)-3-(5-phenylamino-[1,2,4]oxadiazol-3-yl)-piperidin-1-yl]-methanone

{(S)-3-[5-(4-Fluoro-benzylamino)-[1,2,4]oxadiazol-3-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone

[(S)-3-(5-Benzyl-tetrazol-2-yl)-piperidin-1-yl]-(4-fluoro-phenyl)-methanone

{3-[3-(4-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone

(4-Fluoro-phenyl)-[3-(3-phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone

(6-Fluoro-pyridin-3-yl)-[(S)-3-(3-phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone

{(S)-3-[3-(2-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(6-fluoro-pyridin-3-yl)-methanone

{(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(6-fluoro-pyridin-3-yl)-methanone

(4-Fluoro-phenyl)-[(S)-3-(3-phenylsulfanyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone

{3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone

{3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone

(4-Methylphenyl)-[(S)-3-(3-phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone

(2-Methoxy-phenyl)-[(S)-3-(3-phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone

[(S)-3-(3-Phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-pyridin-2-yl-methanone

(2-Fluoro-pyridin-4-yl)-[(S)-3-(3-phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone

(3H-Imidazol-4-yl-[(S)-3-(3-phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone

(3,5-Difluoro-phenyl)-[(S)-3-(3-phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone

(5-Methyl-isoxazol-4-yl)-[(S)-3-(3-phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone

[(S)-3-(3-Phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-thiazol-5-yl-methanone

[(S)-3-(3-Phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-phenyl-methanone

(4-Chloro-phenyl)-[(S)-3-(3-phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone

(4-Methoxy-phenyl)-[(S)-3-(3-phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone

(3,4-Dichloro-phenyl)-[(S)-3-(3-phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone

(3-Methoxy-phenyl)-[(S)-3-(3-phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone

(2-Methyl-phenyl)-[(S)-3-(3-phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone

(2-Fluoro-phenyl)-[(S)-3-(3-phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone

(3-Fluoro-phenyl)-[(S)-3-(3-phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone

[(S)-3-(3-Phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-pyridin-3-yl-methanone

[(S)-3-(3-Phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-pyridin-4-yl-methanone

(3,5-Dimethyl-isoxazol-4-yl)-[(S)-3-(3-phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone

(4-Fluoro-phenyl)-[(S)-3-(3-phenoxy-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-methanone {(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(4-fluoro-phenyl)-methanone

{(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-p-tolyl-methanone

{(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(2-methoxy-phenyl)-methanone

{(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(2-fluoro-pyridin-4-yl)-methanone

{(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(3H-imidazol-4-yl)-methanone

(3,5-Difluoro-phenyl)-{(S)-3-[3-(3-fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-methanone

{(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(5-methyl-isoxazol-4-yl)-methanone

{(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-thiazol-5-yl-methanone

{(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(6-fluoro-pyridin-3-yl)-methanone

{(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-pyridin-2-yl-methanone

{(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-phenyl-methanone

(4-Chloro-phenyl)-{(S)-3-[3-(3-fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-methanone

{(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(4-methoxy-phenyl)-methanone

(3,4-Dichloro-phenyl)-{(S)-3-[3-(3-fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-methanone

{(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(3-methoxy-phenyl)-methanone

{(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-o-tolyl-methanone

{(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(2-fluoro-phenyl)-methanone

{(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(3-fluoro-phenyl)-methanone

{(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-pyridin-3-yl-methanone

{(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-pyridin-4-yl-methanone

{(S)-3-[3-(3-Fluoro-phenoxy)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(3,5-dimethyl-isoxazol-4-yl)-methanone

and pharmaceutically acceptable salts thereof.

14. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1 and a pharmaceutically acceptable carrier and/or excipient.

15. A method of treating or preventing a condition in a mammal, including a human, the treatment or prevention of which is affected or facilitated by the neuromodulatory effect of mGluR5 allosteric modulators, comprising administering to a mammal in need of such treatment or prevention, an effective amount of a compound according to claim 1.

16. A method of treating or preventing a condition in a mammal, including a human, the treatment or prevention of which is affected or facilitated by the neuromodulatory effect of mGluR5 positive allosteric modulators (enhancer), comprising administering to a mammal in need of such treatment or prevention, an effective amount of a compound according to claim 1.

17. A method useful for treating or preventing central nervous system disorders selected from the group consisting of anxiety disorders:

Agoraphobia, Generalized Anxiety Disorder (GAD), Obsessive-Compulsive Disorder (OCD), Panic Disorder, Posttraumatic Stress Disorder (PTSD), Social Phobia, Other Phobias, Substance-Induced Anxiety Disorder, comprising administering an effective amount of a compound according to claim 1.

18. A method useful for treating or preventing central nervous system disorders selected from the group consisting of childhood disorders:

Attention-Deficit/Hyperactivity Disorder), comprising administering an effective amount of a compound according to claim 1.

19. A method useful for treating or preventing central nervous system disorders selected from the group consisting of eating Disorders (Anorexia Nervosa, Bulimia Nervosa), comprising administering an effective amount of a compound according to claim 1.

20. A method useful for treating or preventing central nervous system disorders selected from the group consisting of mood disorders:

Bipolar Disorders (I &

II), Cyclothymic Disorder, Depression, Dysthymic Disorder, Major Depressive Disorder, Substance-Induced Mood Disorder, comprising administering an effective amount of a compound according to claim 1.

21. A method useful for treating or preventing central nervous system disorders selected from the group consisting of psychotic disorders:

Schizophrenia, Delusional Disorder, Schizoaffective Disorder, Schizophreniform Disorder, Substance-Induced Psychotic Disorder, comprising administering an effective amount of a compound according to claim 1.

22. A method useful for treating or preventing central nervous system disorders selected from the group consisting of cognitive disorders:

Delirium, Substance-induced Persisting Delirium, Dementia, Dementia Due to HIV Disease, Dementia Due to Huntington'"'"'s Disease, Dementia Due to Parkinson'"'"'s Disease, Dementia of the Alzheimer'"'"'s Type, Substance-induced Persisting Dementia, Mild Cognitive Impairment, comprising administering an effective amount of a compound according to claim 1.

23. A method useful for treating or preventing central nervous system disorders selected from the group consisting of personality disorders:

Obsessive-Compulsive Personality Disorder, Schizoid, Schizotypal disorder, comprising administering an effective amount of a compound according to claim 1.

24. A method useful for treating or preventing central nervous system disorders selected from the group consisting of substance-related disorders:

Alcohol abuse, Alcohol dependence, Alcohol withdrawal, Alcohol withdrawal delirium, Alcohol-induced psychotic disorder, Amphetamine dependence, Amphetamine withdrawal, Cocaine dependence, Cocaine withdrawal, Nicotine dependence, Nicotine withdrawal, Opioid dependence, Opioid withdrawal, comprising administering an effective amount of a compound according to claim 1.

25. A method useful for treating or preventing inflammatory central nervous system disorders selected from multiple sclerosis form such as benign multiple sclerosis, relapsing-remitting multiple sclerosis, secondary progressive multiple sclerosis, primary progressive multiple sclerosis, progressive-relapsing multiple sclerosis, comprising administering an effective amount of a compound according to claim 1.

26-27. -27. (canceled)