Methods And Devices For Minimally-Invasive Extraocular Delivery of Radiation To The Posterior Portion Of The Eye
First Claim
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1. A method of irradiating a target of an eye in a patient, said method comprising:
- (a) inserting a cannula into a potential space under a Tenon'"'"'s capsule of the eye of the patient, the cannula configured to have a radionuclide brachytherapy source (RBS) at a treatment position,(b) observing through a pupil the position of the treatment position in a posterior pole of the eye,(c) adjusting the cannula that is under the Tenon'"'"'s capsule to achieve fine positioning of the treatment position, the fine positioning is achieved when the treatment position is over a target,(d) irradiating the target with the RBS.
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Abstract
Methods and devices for minimally-invasive delivery of radiation to the posterior portion of the eye including a cannula comprising a distal portion connected to a proximal portion and a means for advancing a radionuclide brachytherapy source (RBS) toward the tip of the distal portion; a method of introducing radiation to the human eye comprising inserting a cannula between the Tenon'"'"'s capsule and the sclera of the human eye and emitting the radiation from the cannula on an outer surface of said sclera.
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Citations
46 Claims
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1. A method of irradiating a target of an eye in a patient, said method comprising:
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(a) inserting a cannula into a potential space under a Tenon'"'"'s capsule of the eye of the patient, the cannula configured to have a radionuclide brachytherapy source (RBS) at a treatment position, (b) observing through a pupil the position of the treatment position in a posterior pole of the eye, (c) adjusting the cannula that is under the Tenon'"'"'s capsule to achieve fine positioning of the treatment position, the fine positioning is achieved when the treatment position is over a target, (d) irradiating the target with the RBS. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 27)
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22. A method of irradiating a target of an eye in a patient, said method comprising:
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(a) inserting a cannula into a potential space under a Tenon'"'"'s capsule of the eye of the patient; (b) placing a distal portion of the cannula on or near a sclera behind the target; (c) observing through a pupil the position of the distal portion of the cannula in a posterior pole of the eye; (d) adjusting the cannula that is under the Tenon'"'"'s capsule to achieve fine positioning of the distal portion of the cannula, the fine positioning is achieved when a treatment position of the distal portion is positioned over a target, (e) advancing a RBS through the cannula to the treatment position of the distal portion via a means for advancing a RBS; and (f) exposing the target to the RBS. - View Dependent Claims (23, 24, 25, 26)
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28. A method of delivering a radiation to an eye, said method comprising irradiating a target on a vitreous side of the eye from an outer surface of a sclera, wherein the target receives a dose rate of greater than about 10 Gy/min, the method further comprises:
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(a) observing through a pupil the position of the treatment position in a posterior pole of the eye, (b) adjusting the cannula that is under the Tenon'"'"'s capsule to achieve fine positioning of the treatment position, the fine positioning is achieved when the treatment position is over a target. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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41. A method of irradiating a target associated with a retina of an eye in a patient, said method comprising placing a radionuclide brachytherapy source (“
- RBS”
) at or near a sclera portion of the eye that corresponds with the target, the RBS irradiates the target through the sclera, wherein more than 1% of a radiation from the RBS is deposited on a tissue at or beyond a distance of 1 cm from the RBS, the method further comprises;(a) observing through a pupil the position of the treatment position in a posterior pole of the eye, (b) adjusting the cannula that is under the Tenon'"'"'s capsule to achieve fine positioning of the treatment position, the fine positioning is achieved when the treatment position is over a target. - View Dependent Claims (42, 43)
- RBS”
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44. A method of irradiating a target of an eye in a patient, said method comprising inserting a cannula between a Tenon'"'"'s capsule and a sclera of the eye of the patient,
the cannula has a radionuclide brachytherapy source (“ - RBS”
) at a distal end, wherein the RBS is positioned over the sclera portion that corresponds with the target, the RBS irradiates the target through the sclera;wherein the target receives a dose rate of greater than about 10 Gy/min; wherein the cannula is a fixed shape cannula; and wherein the RBS is loaded into the cannula after the cannula is inserted; the method further comprising; (a) observing through a pupil the position of a treatment position in a posterior pole of the eye, (b) adjusting the cannula that is under the Tenon'"'"'s capsule to achieve fine positioning of the treatment position, the fine positioning is achieved when the treatment position is over a target. - View Dependent Claims (45, 46)
- RBS”
Specification