NON-INVASIVE METHOD AND APPARATUS FOR DETERMINING A PHYSIOLOGICAL PARAMETER
First Claim
1. A method of noninvasively measuring a global body level physiological parameter of a subject comprising:
- a) locating respective noninvasive sensors on the body of the subject, said sensors outputting separate signals representing respective measured values of at least two disparate measurable physical properties of the subject, the value of each of said disparate physical properties varying in dependence on said physiological parameter and being independently capable of giving a measurement of said body level physiological parameter;
b) obtaining calibration data reflecting the effect of changes in said physiological parameter on the values of each of said at least two disparate measurable physical properties so as to permit the identification of the values of said body level physiological parameter corresponding to particular combinations of values of said disparate measurable physical properties;
c) processing said signals representing said respective measured values of said disparate physical properties in a processor configured to transform said signals into a final value signal representing a quantitative measurement of said body level physiological parameter that is derived from a plurality of said signals and based on the particular combination of the measured values of said disparate properties represented by said signals, whereby said final value is based on the aggregate effect of changes in said physiological parameter on said at least two disparate physical properties predetermined in step b); and
d) outputting said final value of said body level physiological parameter.
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Abstract
The present invention relates to an apparatus and method for the non-invasive analysis of physiological attributes, such as heart rate, blood pressure, cardiac output, respiratory response, body composition, and blood chemistry analytes including glucose, lactate, hemoglobin, and oxygen saturation. Using a combination of multi-functioning disparate sensors, such as optical and electrical, improvements are made over existing physiological measurement devices and techniques. The special configuration of one or more multi-functional sensors is used to non-invasively measure multi-wavelength optical plus one or more of ECG, Bio-impedance, and RF-impedance spectroscopic data. This information is used to develop self-consistent, non-linear algorithm in order to derive the physiological attributes while compensating for various forms of interfering effects including motion artifacts, sensor attachment variability, device component variability, subject physical and physiology variability, and various interfering physiological attributes.
132 Citations
2 Claims
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1. A method of noninvasively measuring a global body level physiological parameter of a subject comprising:
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a) locating respective noninvasive sensors on the body of the subject, said sensors outputting separate signals representing respective measured values of at least two disparate measurable physical properties of the subject, the value of each of said disparate physical properties varying in dependence on said physiological parameter and being independently capable of giving a measurement of said body level physiological parameter; b) obtaining calibration data reflecting the effect of changes in said physiological parameter on the values of each of said at least two disparate measurable physical properties so as to permit the identification of the values of said body level physiological parameter corresponding to particular combinations of values of said disparate measurable physical properties; c) processing said signals representing said respective measured values of said disparate physical properties in a processor configured to transform said signals into a final value signal representing a quantitative measurement of said body level physiological parameter that is derived from a plurality of said signals and based on the particular combination of the measured values of said disparate properties represented by said signals, whereby said final value is based on the aggregate effect of changes in said physiological parameter on said at least two disparate physical properties predetermined in step b); and d) outputting said final value of said body level physiological parameter.
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2. An apparatus for noninvasively measuring a global body level physiological parameter of a subject comprising:
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a) noninvasive sensors for location on the body of the subject, said sensors outputting separate signals representing respective measured values of at least two disparate measurable physical properties of the subject, the value of each of said disparate physical properties varying in dependence on said physiological parameter and being independently capable of giving a measurement of said body level physiological parameter; b) a memory storing calibration data reflecting the effect of changes in said physiological parameter on the values of each of said at least two disparate measurable physical properties so as to permit the identification of the values of said body level physiological parameter corresponding to particular combinations of values of said disparate measurable physical properties; c) a processor configured to processing said signals representing said respective measured values of said disparate physical properties so as to transform said signals into a final value signal representing a quantitative measurement of said body level physiological parameter that is derived from a plurality of said signals and based on the particular combination of the measured values of said disparate properties represented by said signals, whereby said final value is based on the aggregate effect of changes in said physiological parameter on said at least two disparate physical properties predetermined in step b); and d) a display for outputting said final value of said body level physiological parameter.
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Specification