BIOSENSOR CARTRIDGE, METHOD OF USING BIOSENSOR CARTRIDGE, BIOSENSOR DEVICE, AND NEEDLE INTEGRAL SENSOR

• US 20100004559A1
• Filed: 12/17/2007
• Published: 01/07/2010
• Est. Priority Date: 12/19/2006
• Status: Abandoned Application

• Current Assignee: National Institute of Advanced Industrial Science and Technology (Government of Japan), Sumitomo Electric Industries Limited (Sumitomo Corporation)
• Original Assignee: National Institute of Advanced Industrial Science and Technology (Government of Japan), Sumitomo Electric Industries Limited (Sumitomo Corporation)
• Inventors: Fujimura, Tsuyoshi, Nakamura, Hideaki, Gotoh, Masao, Karube, Isao, Ishikawa, Tomoko, Hayami, Hiroshi, Hosoya, Toshifumi, Kitamura, Takahiko, Kaimori, Shingo, Nakajima, Hiroto
• Application Number:
  US12/519,916
• Publication Number:
  US 20100004559A1
• Time in Patent Office: Days
• US Class Current: 600/583
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/150213 Venting means
• CPC Class Codes: A61B 5/150358 Strips for collecting blood, e.g. absorbent optical reagent test strips G01N21/8483; chemical reagent test strips G01N33/4875, G01N33/52
• CPC Class Codes: A61B 5/150412 Pointed piercing elements, e.g. needles, lancets for piercing the skin blade-like piercing elements A61B5/150442
• CPC Class Codes: A61B 5/150503 Single-ended needles hollow piercing element tip design A61B5/150396, needle sets for catheters A61M25/06, needles for bringing media into the body A61M5/32
• CPC Class Codes: A61B 5/150549 Protectors removed by rotational movement, e.g. torsion or screwing
• CPC Class Codes: A61B 5/150618 Integrally moulded protectors, e.g. protectors simultaneously moulded together with a further component, e.g. a hub, of the piercing element
• CPC Class Codes: A61B 5/150717 manually removed
• CPC Class Codes: A61B 5/15113 Manually triggered, i.e. the triggering requires a deliberate action by the user such as pressing a drive button
• CPC Class Codes: A61B 5/15117 comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
• CPC Class Codes: A61B 5/1519 comprising driving means, e.g. a spring, for propelling the piercing unit

Abstract

A biosensor cartridge capable of making the collected amount of a sample required for measurement into a small quantity to reduce a user'"'"'s burden, and easily collecting and measuring a sample of a puncture hole without requiring the operation of bringing a sample collection opening close to the puncture hole is provided. When one end portion of biosensor chip is pushed against subject, elastic body is compressed, and puncturing tool can protrude and perform puncturing. Additionally, if a pushing force is weakened, puncturing tool is extracted from subject by the restoring force of elastic body, and blood (sample) flows out of the puncture hole. In this case, since the puncture hole, and sample collection opening provided at biosensor chip are contained in enclosed half-open space formed by elastic body, even a small amount of blood (sample) can also be easily collected. Additionally, elastic body is formed with a groove which forms a ventilation passage, so that enclosed half-open space can be opened to the atmosphere.

Claims

1. A biosensor cartridge comprising:

a biosensor chip, and

a puncturing tool fixed to a portion of the biosensor chip and having a tip protruding therefrom, wherein

an elastic body having a through hole which contains a sample collection opening provided at a tip of the biosensor chip and a puncture hole formed in a subject by the puncturing tool is provided at a tip of the biosensor chip, and

the elastic body includes a ventilation passage which passes through between an internal wall surface which forms the through hole and an external wall surface of the elastic body.

2. The biosensor cartridge of claim 1, wherein

the sample collection opening provided at the tip of the biosensor chip and the puncture hole formed in the subject by the puncturing tool are connected together by the through hole.

3. The biosensor cartridge of claim 1, wherein

the elastic body is configured such that the internal diameter of the hole on the side which touches the subject is made larger than the internal diameter of the hole on the side which touches the biosensor chip.

4. The biosensor cartridge of claim 3, wherein

the elastic body is configured such that the internal wall surface which forms the through hole is raised toward the tip of the elastic body on the side which touches the subject.

5. The biosensor cartridge of claim 1, wherein

the ventilation passage is a groove provided at the end face of the elastic body on the side of the subject.

6. The biosensor cartridge of claim 1, wherein

the ventilation passage is an open through hole formed substantially along a radial direction of the elastic body.

7. The biosensor cartridge of claim 1, wherein

a plurality of the ventilation passages are formed in the elastic body, and are arranged so as to be symmetrical in the radial direction of the elastic body with the axial center of the elastic body as a center.

8. The biosensor cartridge of claim 1, further comprising:

a drive mechanism which punctures a subject with the puncturing tool.

9. The biosensor cartridge of claim 1, wherein

the elastic body has stickiness.

10. The biosensor cartridge of claim 1, wherein

the elastic body is fixed to the tip of the biosensor chip with its own stickiness, fixed to the tip of the biosensor chip with an adhesive, or fixed to the tip of the biosensor chip with a double-sided tape.

11. A method of using a biosensor cartridge of claim 1, the method comprising the steps of:

pushing the elastic body against the subject to compress the elastic body to puncture the subject,

pulling out a puncturing tool from the subject by a restoring force of the elastic body, and

performing sample collection while the through hole is opened to the atmosphere.

12. A biosensor device comprising:

the biosensor cartridge of claim 1, and

a measuring instrument which is connected to detecting electrodes of the biosensor cartridge and obtains information on a sample which has been collected.

13. A needle integral sensor comprising:

a needle integral sensor body integrally having a puncturing needle which discharges a liquid sample from a subject, a reaction portion which contains the liquid sample, and a detecting portion which detects the result of the reaction portion; and

a flow passage forming body in which a through hole serving as a flow passage from an abutting portion of the subject to the reaction portion is provided, and in which the puncturing needle is inserted into the through hole, wherein

the flow passage forming body is formed with a ventilation passage which communicates the through hole and the outside of the flow passage forming body with each other.

14. The needle integral sensor of claim 13, wherein

the flow passage forming body is an elastic body or viscoelastic body which enables the puncturing needle to project and retract from the through hole by deformation.

15. The needle integral sensor of claim 13, wherein

the ventilation passage is provided in an attachment portion of the needle integral sensor body.

16. The needle integral sensor of claim 15, wherein

the ventilation passage is provided so that the reaction portion inlet is located midway of the ventilation passage or in the vicinity of the ventilation passage inlet.

17. The needle integral sensor of claim 13, wherein

the ventilation passage is provided with a liquid outflow preventing mechanism.

18. The needle integral sensor of claim 17, wherein

the liquid outflow preventing mechanism is a curved portion provided at a midway of the ventilation passage.

19. The needle integral sensor of claim 13, wherein

a surfactant is applied at least in the vicinity of an inlet of the reaction portion.