Method for Treatment of Complications Associated with Arteriovenous Grafts and Fistulas Using Electroporation
First Claim
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1. A method for the treatment of a complication associated with an arteriovenous graft or fistula comprising:
- positioning at least two electrodes near a target zone of complication formed on the graft or fistula; and
applying between the positioned electrodes electrical pulses in an amount sufficient to subject substantially all cells within the target zone to irreversible electroporation.
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Abstract
Electroporation devices and methods for use in the treatment of complications, such as thrombosis, stenotic segments, or infections, associated with an arteriovenous graft or fistula are provided. The devices include at least two electrodes. The electrodes are adapted to be positioned near the target zone of complication for applying electrical pulses and thereby causing electroporation. In a preferred embodiment, the electroporation pulses are sufficient to subject substantially all cells within the target zone to irreversible electroporation without creating a thermally damaging effect.
208 Citations
27 Claims
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1. A method for the treatment of a complication associated with an arteriovenous graft or fistula comprising:
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positioning at least two electrodes near a target zone of complication formed on the graft or fistula; and applying between the positioned electrodes electrical pulses in an amount sufficient to subject substantially all cells within the target zone to irreversible electroporation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for the treatment of a complication associated with an arteriovenous graft or fistula comprising:
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positioning at least two electrodes near a target zone of complication formed on the graft or fistula; connecting a voltage generator to the at least two electrodes; applying between the positioned electrodes electrical pulses from the voltage generator in an amount sufficient to subject substantially all cells within the target zone to irreversible electroporation without creating a thermally damaging effect to a majority of the tissue within the target zone. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method for the treatment of a complication associated with an arteriovenous graft or fistula comprising:
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inserting into the arteriovenous graft or fistula a balloon catheter whose balloon carries at least two electrodes; positioning the at least two electrodes near a target zone of complication formed on the graft or fistula; connecting the at least two electrodes to a voltage generator; expanding the balloon; applying between the connected electrodes electrical pulses in an amount sufficient to subject substantially all cells within the target zone to irreversible electroporation without creating a thermally damaging effect; collapsing the balloon; removing the balloon catheter from the arteriovenous graft or fistula. - View Dependent Claims (22)
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23. A method for the treatment of a complication associated with an arteriovenous graft or fistula comprising:
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positioning at least two electrodes near a target zone of complication formed on the graft or fistula; delivering a therapeutic agent to the target zone of complication; applying between the positioned electrodes electrical pulses in an amount sufficient to subject substantially all cells within the target zone to reversible electroporation. - View Dependent Claims (24, 25, 26, 27)
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Specification