METHOD OF TREATING TISSUE WITH A SUSPENSON OF TRICALCIUM HYDROXYAPATITE MICROSPHERES

• US 20100004700A1
• Filed: 03/05/2009
• Published: 01/07/2010
• Est. Priority Date: 03/05/2008
• Status: Abandoned Application

• Current Assignee: SpineOvations Inc
• Original Assignee: SpineOvations Inc
• Inventors: Alleyne, Neville
• Application Number:
  US12/398,764
• Publication Number:
  US 20100004700A1
• Time in Patent Office: Days
• US Class Current: 606/86.R
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61F 2/08 Muscles; Tendons; Ligaments sutures A61B17/04
• CPC Class Codes: A61F 2002/30056 differing in radiographic density
• CPC Class Codes: A61F 2002/3008 radio-opaque, e.g. radio-opaque markers
• CPC Class Codes: A61F 2002/30242 spherical
• CPC Class Codes: A61F 2002/30588 filled with solid particles
• CPC Class Codes: A61F 2002/444 for replacing the nucleus pulposus
• CPC Class Codes: A61F 2230/0071 spherical
• CPC Class Codes: A61F 2250/0032 differing in radiographic density
• CPC Class Codes: A61F 2250/0098 radio-opaque, e.g. radio-opaque markers
• CPC Class Codes: A61F 2310/00293 containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 9/0085 Brain, e.g. brain implants; Spinal cord
• CPC Class Codes: A61K 9/06 Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61L 2400/06 Flowable or injectable implant compositions
• CPC Class Codes: A61L 2430/38 for reconstruction of the spine, vertebrae or intervertebral discs
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids

Abstract

A method of treating an intervertebral disk according to the present invention can include delivering a composition to treat the intervertebral disk. The composition has a plurality of microspheres, and can comprise tricalcium hydroxyapatite microspheres suspended in a sodium carboxymethyl cellulose gel. The composition results in at least one of sealing the defect, increasing a pressure of the disk, increasing a height of the disk, improving stability of the disk and improving structural integrity of the disk.

Claims

1. A method of treating a intervertebral disk comprising:

performing a discography procedure; and

delivering a composition to the invertebral disk through at least one aperture present in the spinal disk created during said discography procedure, wherein the composition comprises tricalcium hydroxyapatite microspheres suspended in a sodium carboxymethyl cellulose gel.

2. The method of claim 1, further comprising:

identifying an annular tear in an intervertebral disk; and

delivering the composition to the intervertebral disk in the region of the annular tear.

3. The method of claim 1, wherein delivering the composition comprises delivering the composition to a nucleus pulposus of the intervertebral disk.

4. The method of claim 2, further comprising at least one of stabilizing the annular tear, reducing loss in the height of the disk, preserving the height of the disk, increasing the height of the disk, increasing a pressure of the disk, improving stability of the disk, and improving structural integrity of the disk.

5. The method of claim 1, wherein the composition comprises approximately 30 percent tricalcium hydroxyapatite microspheres.

6. The method of claim 5, wherein the microspheres have diameters between approximately 25 to 40 microns.

7. The method of claim 2, wherein the annular tear is identified using one of a CT scan, a CT myelography, an MRI scan, and an ultrasound scan.

8. The method of claim 1, wherein delivering the composition comprises viewing the intervertebral disk through a scope.

9. The method of claim 1, wherein the composition comprises a radiopaque material, the method further comprising visualizing the composition by means of the radiopaque material.

10. The method of claim 9, wherein the radiopaque material is metrizamide, barium, or a radial opaque dye.

11. A method of treating a ligament or tendon comprising identifying a defect in the ligament or tendon and delivering a composition into the tissue of the ligament or tendon, wherein the composition comprises tricalcium hydroxyapatite microspheres suspended in a sodium carboxymethyl cellulose gel.

12. The method of claim 11, wherein delivering comprises using a syringe.

13. The method of claim 11, wherein delivering comprises delivering a mesh impregnated with the composition into the tissue.

14. The method of claim 13, wherein the mesh has a generally cylindrical shape.

15. The method of claim 13, wherein the mesh has a generally rectangular shape.

16. The method of claim 13, wherein the mesh has a generally hemispherical shape.

17. The method of claim 13, wherein the mesh is delivered into the tissue arthroscopically or laparoscopically.

18. The method of claim 11, wherein the ligament comprises at least one of an anterior longitudinal ligament, a posterior longitudinal ligament, a supraspinous ligament, an intraspinous ligament, a capsular ligament, an anterior cruciate ligament (ACL), a posterior cruciate ligament (PCL), and a rotator cuff.

19. The method of claim 11, wherein the composition forms a biological scaffold comprising at least a portion of the microspheres, and wherein the biological scaffold operates at least as partial connective tissue in the ligament or tendon.

20. A method of treating a fascial tissue comprising:

identifying an inguinal, umbilical, or abdominal wall defect; and

delivering a composition into the fascial tissue in the region of the defect, wherein the composition comprises tricalcium hydroxyapatite microspheres suspended in a sodium carboxymethyl cellulose gel.

21. The method of claim 20, wherein delivering comprises delivering a mesh impregnated with the composition into the tissue.

22. The method of claim 20, wherein delivering comprises using a syringe.

23. A method of treating an intervertebral disk comprising:

inserting one or more needles into the intervertebral disk creating one or more apertures in the intervertebral disk;

injecting contrasting die into the intervertebral disk; and

delivering a composition to the intervertebral disk through at least one of said one or more apertures, wherein the composition comprises tricalcium hydroxyapatite microspheres suspended in a sodium carboxymethyl cellulose gel.

24. A method of treating an intervertebral disk comprising placing a plurality of tricalcium hydroxyapatite particles suspended in a sodium carboxymethyl cellulose gel into an interior portion of the intervertebral disk.