Non-covalent modification of microparticles and process of preparing same
First Claim
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1. A surface-modified microparticle comprising:
- a microparticle core and at least one monolayer associated with the microparticle core;
wherein the monolayer comprises an amphiphilic polymer or a nonionic polymer grafted to an ionic polymer; and
the microparticle core comprises a macromolecule selected from the group consisting of carbohydrates, peptides, proteins, vectors, nucleic acids, complexes thereof, and conjugates thereof.
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Abstract
The present disclosure is directed to surface-modified microparticles, pharmaceutical compositions thereof, and methods of making and using such particles. The surface-modified microparticles include a microparticle core, and at least one monolayer associated with the microparticle core. The monolayer comprises an amphiphilic polymer or non-ionic polymer grafted to an ionic polymer.
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Citations
61 Claims
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1. A surface-modified microparticle comprising:
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a microparticle core and at least one monolayer associated with the microparticle core; wherein the monolayer comprises an amphiphilic polymer or a nonionic polymer grafted to an ionic polymer; and the microparticle core comprises a macromolecule selected from the group consisting of carbohydrates, peptides, proteins, vectors, nucleic acids, complexes thereof, and conjugates thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. A process of preparing a surface-modified microparticle comprising a grafted polymer comprising:
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a) providing a microparticle core comprising a macromolecule selected from the group consisting of carbohydrates, peptides, proteins, vectors, nucleic acids, complexes thereof, and conjugates thereof; b) admixing (i) an activated amphiphilic or nonionic polymer and (ii) an ionic polymer under conditions sufficient to form a grafted polymer, said grafted polymer comprising the amphiphilic polymer or nonionic polymer grafted to the ionic polymer; and c) admixing the grafted polymer of (b) and the microparticle core under conditions sufficient to form a surface-modified microparticle comprising a grafted polymer and having an outermost monolayer, said outermost monolayer comprising the amphiphilic polymer or nonionic polymer grafted to the ionic polymer. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
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52. A surface-modified microparticle comprising:
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a microparticle core and at least one monolayer associated with the microparticle core; wherein the monolayer comprises an amphiphilic polymer or a nonionic polymer grafted to an ionic polymer; and the microparticle core comprises a macromolecule. - View Dependent Claims (53, 54, 55, 56)
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57. A process of preparing a surface-modified microparticle comprising a grafted polymer comprising:
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a) providing a microparticle core comprising an active agent; b) admixing (i) an activated amphiphilic or nonionic polymer and (ii) an ionic polymer under conditions sufficient to form a grafted polymer, said grafted polymer comprising the amphiphilic polymer or nonionic polymer grafted to the ionic polymer; and c) admixing the grafted polymer of (b) and the microparticle core under conditions sufficient to form a surface-modified microparticle comprising a grafted polymer and having an outermost monolayer, said outermost monolayer comprising the amphiphilic polymer or nonionic polymer grafted to the ionic polymer. - View Dependent Claims (58, 59, 60, 61)
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Specification