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Dye Compounds and the Use of their Labelled Conjugates

  • US 20100009353A1
  • Filed: 05/16/2007
  • Published: 01/14/2010
  • Est. Priority Date: 05/18/2006
  • Status: Active Grant
First Claim
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1. A compound of the formula s:

  • wherein X is SO3H or SO3

    , M+ is a common counter ion, k, n, m are independently integers of from 1 to 6, R1 is H or an alkyl or substituted alkyl group, R2 is H, alkyl or substituted alkyl group, halogen, carboxy, carboxamide, hydroxy- or alkoxy group, or R2 together with R1 or R5 is a carbon or heterosubstituted chain forming a ring, R3 is H, alkyl or substituted alkyl group, halogen, carboxy, carboxamide, hydroxy- or alkoxy group or R3 together with R4 or R6 is a carbon or heterosubstituted chain forming a ring, R4 is H, or an alkyl or substituted alkyl group, R5 and R6 are H, alkyl or substituted alkyl group, halogen, hydroxy- or alkoxy group, R8 is H, halogen, hydroxy- or alkoxy group, alkyl or substituted alkyl group or together with R1 is a carbon or heterosubstituted carbon chain forming a ring, R9 is H, halogen, hydroxy- or alkoxy group, alkyl or substituted alkyl group or together with R4 is a carbon or heterosubstituted carbon chain forming a ring, R7 is OH, OR10 where R10 is alkyl or substituted alkyl, or NR11R12 where R11 and R12 are independently H, alkyl or a substituted alkyl, or is joined to form aliphatic or aromatic cyclic or substituted aliphatic-, aromatic- or heterocyclic rings, Z is halogen, amino or substituted amino, hydroxyl-, alkoxy-, carboxy-, carboxamido- or a substituted carboxamido group, SO3H or SO3

    and a is 0 to 4, wherein if a is 0, R7 is NR11R12 where R11 and R12 are independently H, alkyl or a substituted alkyl.

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