Functionalized Inclusion Complexes As Crosslinkers

• US 20100010159A1
• Filed: 06/29/2009
• Published: 01/14/2010
• Est. Priority Date: 07/11/2008
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Tyco Healthcare Group LP (Medtronic Plc)
• Inventors: Belcheva, Nadya
• Granted Patent: US 8,207,264 B2
• Time in Patent Office: Days
• US Class Current: 525/54.200
• CPC Class Codes: C08B 37/0015 Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
• CPC Class Codes: C08L 5/16 Cyclodextrin; Derivatives thereof

Abstract

The present disclosure relates to crosslinked polymer compositions comprising an inclusion complex functionalized with one or more reactive groups and a polymer functionalized with one or more complimentary reactive groups.

Claims

1. A composition comprising:

an inclusion complex functionalized with one or more reactive groups, and a polymer functionalized with one or more complimentary reactive groups capable of covalently bonding with the reactive groups present on the inclusion complex.

2. The composition of claim 1 wherein the functionalized inclusion complex comprises one or more cyclic oligosaccharides and linear polymer chains.

3. The composition of claim 2 wherein the one or more cyclic oligasaccharide is a cyclodextrin.

4. The composition of claim 2 wherein the one or more linear polymer chain is polyethylene glycol.

5. The composition of claim 1 wherein the functionalized inclusion complex comprises one or more cyclic oligosaccharides and multi-armed polymer chains.

6. The composition of claim 1 wherein the functionalized inclusion complex comprises one or more reactive groups selected from the group consisting of electrophilic groups, nucleophilic groups and combinations thereof.

7. The composition of claim 1 wherein the functionalized polymer comprises one or more complimentary reactive groups selected from the group consisting of electrophilic groups, nucleophilic groups and combinations thereof.

8. The composition of claim 1 wherein the functionalized inclusion complex further comprises a chain extender selected from the group consisting of a linking group, a biodegradable group, and combinations thereof.

9. The composition of claim 1 wherein the functionalized polymer further comprises a chain extender selected from the group consisting of a linking group, a biodegradable group, and combinations thereof.

10. A composition comprising:

an inclusion complex functionalized with one or more electrophilic groups, and a polymer functionalized with one or more nucleophilic groups.

11. The composition of claim 10 wherein the functionalized inclusion complex comprises one or more cyclic oligosaccharides and linear polymer chains.

12. The composition of claim 11 wherein the one or more cyclic oligasaccharide is a cyclodextrin.

13. The composition of claim 11 wherein the one or more linear polymer chain is polyethylene glycol.

14. The composition of claim 10 wherein the functionalized inclusion complex comprises one or more cyclic oligosaccharides and multi-armed polymer chains.

15. The composition of claim 10 wherein the functionalized inclusion complex comprises electrophilic groups selected from the group consisting of —

CO₂N(COCH₂)₂, —

CO₂H, —

CHO, —

CHOCH₂, —

N═

C═

O, —

SO₂CH═

CH₂, —

N(COCH)₂, —

S—

S—

(C₅H₄N), and combinations thereof.

16. The composition of claim 10 wherein the functionalized polymer comprises one or more nucleophilic groups selected from the group consisting of —

NH₂, —

SH, —

OH, —

PH₂, —

CO—

NH—

NH₂ and combinations thereof.

17. The composition of claim 10 wherein the functionalized inclusion complex further comprises a chain extender selected from the group consisting of a linking group, a biodegradable group, and combinations thereof.

18. The composition of claim 10 wherein the functionalized polymer further comprises a chain extender selected from the group consisting of a linking group, a biodegradable group, and combinations thereof.

19. A composition comprising:

an inclusion complex functionalized with one or more nucleophilic groups, and a polymer functionalized with one or more electrophilic groups.

20. The composition of claim 19 wherein the functionalized inclusion complex comprises one or more cyclic oligosaccharides and linear polymer chains.

21. The composition of claim 20 wherein the one or more cyclic oligasaccharide is a cyclodextrin.

22. The composition of claim 20 wherein the one or more linear polymer chain is polyethylene glycol.

23. The composition of claim 19 wherein the functionalized inclusion complex comprises one or more cyclic oligosaccharides and multi-armed polymer chains.

24. The composition of claim 19 wherein the functionalized inclusion complex comprises electrophilic groups selected from the group consisting of —

CO₂N(COCH₂)₂, —

CO₂H, —

CHO, —

CHOCH₂, —

N═

C═

O, —

SO₂CH═

CH₂, —

N(COCH)₂, —

S—

S—

(C₅H₄N), and combinations thereof.

25. The composition of claim 19 wherein the functionalized polymer comprises one or more nucleophilic groups selected from the group consisting of —

NH₂, —

SH, —

OH, —

PH₂, —

CO—

NH—

NH₂ and combinations thereof.

26. A composition comprising:

a first inclusion complex functionalized with one or more nucleophilic groups, and a second inclusion complex functionalized with one or more electrophilic groups.

27. A method for preparing a composition comprising the steps of:

providing an inclusion complex functionalized with one or more electrophilic groups and a polymer functionalized with one or more nucleophilic groups;

forming a mixture by mixing the functionalized inclusion complex with the functionalized polymer to initiate crosslinking; and

allowing the functionalized inclusion complex and the functionalized polymer to continue crosslinking to form a crosslinked polymer composition.