Temperature-compensated in-vivo sensor
First Claim
Patent Images
1. An in-vivo sensor for measuring an analyte, the sensor comprising:
- a base insulating layer;
an electrically conductive electrode disposed on the base insulating layer;
a semi-permeable layer disposed over the electrode;
a first hydrogel layer containing an enzyme that is a substrate for the analyte disposed on the semi-permeable layer;
a composite membrane layer disposed on the first hydrogel layer wherein the composite layer includes a hydrogel containing a plurality of microspheres, the plurality of microspheres being made of a material having no or little permeability to the analyte and substantially high permeability to oxygen.
2 Assignments
0 Petitions
Accused Products
Abstract
A reagent matrix composition disposed on an electrically conductive electrode to form an in-vivo sensor for a predefined analyte includes a first hydrogel layer containing an enzyme that is a substrate for the analyte adjacent the electrically conductive electrode and a composite membrane layer disposed onto the first hydrogel layer where the composite layer includes a membrane hydrogel containing a plurality of microspheres. The plurality of microspheres is made of a material having no or little permeability to the analyte and a substantially high permeability to oxygen.
-
Citations
21 Claims
-
1. An in-vivo sensor for measuring an analyte, the sensor comprising:
-
a base insulating layer; an electrically conductive electrode disposed on the base insulating layer; a semi-permeable layer disposed over the electrode; a first hydrogel layer containing an enzyme that is a substrate for the analyte disposed on the semi-permeable layer; a composite membrane layer disposed on the first hydrogel layer wherein the composite layer includes a hydrogel containing a plurality of microspheres, the plurality of microspheres being made of a material having no or little permeability to the analyte and substantially high permeability to oxygen. - View Dependent Claims (2, 3, 4, 5, 6, 7)
-
-
8. A reagent matrix composition disposed on an electrically conductive electrode to form an in-vivo sensor for a predefined analyte, the composition comprising:
-
a first hydrogel layer containing an enzyme that is a substrate for the analyte adjacent the electrically conductive electrode; and a composite membrane layer disposed onto the first hydrogel layer wherein the composite layer includes a membrane hydrogel containing a plurality of microspheres, the plurality of microspheres being made of a material having no or little permeability to the analyte and a substantially high permeability to oxygen. - View Dependent Claims (9, 10, 11, 12, 13, 14)
-
-
15. A method of making a sensor for in-vivo measurement of an analyte, the method comprising:
-
obtaining an electrically conductive electrode; disposing a first hydrogel layer containing an enzyme onto the electrically conductive electrode; and disposing a composite membrane layer onto the first hydrogel layer wherein the composite membrane layer includes a membrane hydrogel containing a plurality of microspheres, the plurality of microspheres being made of a material having no or little permeability to the analyte and a substantially high permeability to oxygen. - View Dependent Claims (16, 17, 18, 19, 20, 21)
-
Specification