NERVOUS SYSTEM MONITORING METHOD

• US 20100010369A1
• Filed: 03/31/2009
• Published: 01/14/2010
• Est. Priority Date: 04/22/2003
• Status: Abandoned Application

• Current Assignee: University of Manchester
• Original Assignee: University of Manchester
• Inventors: MCCANN, HUGH, POMFRETT, CHRISTOPHER JOHN DOUGLAS
• Application Number:
  US12/415,764
• Publication Number:
  US 20100010369A1
• Time in Patent Office: Days
• US Class Current: 600/554
• CPC Class Codes: A61B 5/0042 for the brain
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: A61B 5/378 Visual stimuli
• CPC Class Codes: A61B 5/38 Acoustic or auditory stimuli
• CPC Class Codes: A61B 5/4041 Evaluating nerves condition

Abstract

A method for monitoring the response of a nervous system of a body to a stimulus. The method comprises collecting a set of voltage measurements between selected areas on a surface of the body whilst current is being passed between selected regions of the surface of the body. The set of voltage measurements is collected over a predetermined measurement period, the predetermined measurement period is based upon a time after application of the stimulus, and the collected voltage measurements are compared with reference measurements to determine normal or abnormal response of the nervous system.

Claims

1. A method for monitoring the response of a nervous system of a body to a stimulus, the method comprising:

providing a plurality of electrodes on a surface of the body and passing current between selected areas of the surface of the body by passing current between at least one pair of electrodes of said plurality of electrodes, said current being provided by a current source external to said body;

collecting voltage measurements between selected ones of said electrodes while said current is passed between said at least one pair of electrodes;

receiving as input a time delay; and

processing at least some of said collected voltage measurements to determine a response of the nervous system to the stimulus;

wherein said at least some of said collected voltage measurements are collected during a measurement period beginning after a delay based upon the input time delay following occurrence of said stimulus.

2. A method according to claim 1, wherein said processing is based upon a subset of the collected voltage measurements.

3. A method according to claim 1, wherein current is sequentially passed between a plurality of pairs of electrodes and voltage measurements are collected between selected ones of said electrodes while current is passed between each pair of said plurality of pairs of electrodes.

4. A method according to claim 3, wherein current is repeatedly sequentially passed between the plurality of pairs of electrodes and voltage measurements are collected between selected ones of said electrodes while current is passed between each pair of said plurality of pairs of electrodes.

5. A method according to claim 1, further comprising applying said stimulus.

6. A method according to claim 5, wherein voltage measurements are collected independently of stimulus application.

7. A method according to claim 1, wherein the stimulus is selected from the group consisting of a visual stimulus, an auditory stimulus, a sensory stimulus and a transcranial magnetic stimulus.

8. A method according to claim 1, wherein said processing comprises producing an image representing the distribution of impedance within the body.

9. A method according to claim 1, wherein said processing comprises comparing said at least some of said collected voltage measurements with reference data.

10. A method according to claim 1, wherein the stimulus occurs spontaneously.

11. A method according to claim 1, wherein the stimulus is a feature of an environment in which the body is located.

24. A computer-readable computer program storage medium containing computer program code which, when executed by a computer effects a procedure in accordance with the method of claim 1.

12. A method for monitoring nervous system response to a stimulus, said method comprising:

(a) injecting electrical current for a first time period through at least a first pair of electrodes of a plurality of electrodes affixed to a subject;

(b) during said first time period, measuring electrical voltage between selected ones of said plurality of electrodes;

(c) subsequent to said first time period, injecting electrical current for another time period through at least another pair of said plurality electrodes;

(d) during said another time period, measuring electrical voltages between selected ones of said electrodes of said plurality of electrodes;

(e) repeating steps (c) and (d);

(f) applying a predetermined stimulus to a nervous system of the subject

(g) receiving as input a time delay;

(h) selecting some of said voltage measurements based upon a time at which said stimulus is applied and said received input time delay;

(i) processing said selected voltage measurements to determine a response of the nervous system of the body to the stimulus.

13. A method according to claim 12, wherein said first time period and said another time period have substantially equal lengths.

14. A method according to claim 12, wherein said injecting is carried out independently of said stimulus application.

15. A method for monitoring the response of a predetermined part of a nervous system of a body to an applied stimulus, said method comprising:

identifying the predetermined part of the nervous system;

providing a plurality of electrodes on a surface of the body and passing current between selected areas of the surface of the body by passing current between at least one pair of electrodes of said plurality of electrodes, said current being provided by a current source external to said body; and

collecting voltage measurements between selected ones of said electrodes while said current is being passed between said at least one pair of electrodes;

processing at least some of said collected voltage measurements to determine a response of the nervous system to the stimulus;

wherein said at least some of said collected voltage measurements are collected during a measurement period beginning after a delay following application of the stimulus, the delay being based upon a neurological model of the nervous system and the predetermined part of the nervous system for which a response is monitored.

16. A method of monitoring the response of a nervous system of a body to a stimulus the method comprising:

(a) sequentially injecting current between each of a plurality of pairs of electrodes of a plurality of electrodes on a surface of the body so as to pass current between selected areas on the surface of the body;

(b) collecting a respective set of voltage measurements between selected ones of said plurality of electrodes during injection of current between each of said plurality of pairs of electrodes so as to generate a plurality of sets of voltage measurements;

(c) repeating steps (a) and (b) a plurality of times;

(d) applying a stimulus to the nervous system of said body, said stimulus being applied while current is injected between one of said plurality of pairs of electrodes;

(e) selecting some of said sets of voltage measurements based upon a time delay and a time at which said stimulus is applied; and

(f) processing said selected sets of voltage measurements to determine a response of the nervous system to the applied stimulus at a time following stimulus application determined by said time delay.

17. A method according to claim 16, wherein the stimulus is selected from the group consisting of a visual stimulus, an auditory stimulus, a sensory stimulus and a transcranial magnetic stimulus.

18. A method according to claim 16, wherein said processing comprises producing an image representing the distribution of impedance within the body.

19. A method according to claim 16, wherein said processing comprises comparing said at least some of said collected voltage measurements with reference data.

20. A method according to claim 16, wherein said processing is arranged to determine normal or abnormal behaviour of the nervous system.

21. A method according to claim 16, wherein said processing is arranged to diagnose brain dysfunction.

22. Apparatus for monitoring the response of a nervous system of a body to a stimulus, the apparatus comprising:

a plurality of electrodes for attaching to the surface of the body;

a current source connected to said electrodes; and

a processor;

wherein said processor is arranged to;

(a) sequentially inject current between each of a plurality of first pairs of electrodes of said plurality of electrodes so as to pass current between selected areas on the surface of the body;

(b) collect a respective set of voltage measurements between second pairs of said plurality of electrodes during injection of current between each of said plurality of pairs of electrodes so as to generate a plurality of sets of voltage measurements;

(c) repeat steps (a) and (b) a plurality of times;

(d) apply a stimulus to a nervous system of said body, said stimulus being applied while current is injected between one of said plurality of pairs of electrodes;

(e) select some of said sets of voltage measurements based upon a time delay and a time at which said stimulus is applied; and

(f) process said selected sets of voltage measurements to determine a response of the nervous system to the applied stimulus.

23. Apparatus for monitoring the response of a nervous system of a body to a stimulus, the apparatus comprising:

a plurality of electrodes for attaching to the surface of the body;

a current source connected to said electrodes; and

a processor;

wherein said processor is arranged to;

pass current between selected areas of the surface of the body by passing current between at least one pair of electrodes of said plurality of electrodes, said current being provided by said current source;

collect voltage measurements between selected ones of said electrodes while said current is passed between said at least one pair of electrodes;

receive as input a time delay; and

process at least some of said collected voltage measurements to determine a response of the nervous system to the stimulus, said at least some of said collected voltage measurements being collected during a measurement period beginning after a delay based upon the input time delay following occurrence of said stimulus.