Self-Contained Medical Applicators for Multiple Component Formulations, and Methods of Use Thereof
First Claim
1. An applicator, comprising a rear housing, a front housing, a mechanical interlock and a nozzle assembly;
- wherein(i) the rear housing comprises;
a first barrel, having a first diameter;
a first end;
a second end;
a first internal chamber;
a first piercer, attached to the second end of the first barrel, having a first fluid passageway; and
a first plunger, having a first end and a second end, located at least partially within the first internal chamber and under pressure moveable therethrough; and
a second barrel having a second diameter;
a first end;
a second end;
a second internal chamber;
a second piercer, located on the second end of the second barrel, having a second fluid passageway; and
a second plunger, having a first end and a second end, located at least partially within the second internal chamber and under pressure moveable therethrough;
(ii) the front housing comprises;
a third barrel, having a third diameter;
a first end;
a second end;
a third internal chamber;
a first piston having a third fluid passageway therethrough, located within the third internal chamber and under pressure moveable therethrough;
a first piercable barrier, located at the first end of the third barrel and suitably positioned to be pierced by the first piercer, thereby allowing fluid communication between the first internal chamber and the second internal chamber via the first fluid passageway and the third fluid passageway; and
a second piercable barrier, located at the second end of the third barrel; and
a fourth barrel, having a fourth diameter;
a first end;
a second end;
a fourth internal chamber;
a second piston having a fourth fluid passageway therethrough, located within the fourth internal chamber and under pressure moveable therethrough;
a third piercable barrier, located at the first end of the fourth barrel and suitably positioned to be pierced by the second piercer, thereby allowing fluid communication between the second internal chamber and the fourth internal chamber via the second fluid passageway and the fourth fluid passageway; and
a fourth piercable barrier, located at the second end of the fourth barrel; and
(iii) the nozzle assembly comprises;
a fifth internal chamber;
having a first inlet with a third piercer affixed thereto, which comprises a fifth fluid passageway, and is suitably positioned at the first inlet to pierce the second piercable barrier and thereby allow fluid communication between the third internal chamber and the fifth internal chamber via the fifth fluid passageway;
a second inlet with a fourth piercer affixed thereto, which comprises a sixth fluid passageway, and is suitably positioned at the second inlet to pierce the fourth piercable barrier and thereby allow fluid communication between the fourth internal chamber and the fifth internal chamber via the sixth fluid passageway; and
an outlet;
wherein the nozzle assembly is connected to the front housing;
the front housing is connected to the rear housing;
the first diameter is less than the third diameter;
the second diameter is less than the fourth diameter;
the first piercer is sized to block the first fluid passageway;
the second piercer is sized to block the second fluid passageway; and
the mechanical interlock is positioned to allow initially the first piercer to pierce the first barrier but not block the first fluid passageway; and
the mechanical interlock is positioned to initially allow the second piercer to pierce the second barrier but not block the second fluid passageway.
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Accused Products
Abstract
Certain aspects of the invention relate to an applicator, and methods of use thereof, which can house multiple component formulations in separate material receptacles, which can then be easily reconstituted at time of use without any assembly by the user. A device of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, and any of the internal tissues. A device of the invention can be configured to apply a spray or a stream of liquid formulation onto a surface to be treated. A device of the invention can be configured to deliver the formulation through an endoscope or laparoscope.
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Citations
20 Claims
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1. An applicator, comprising a rear housing, a front housing, a mechanical interlock and a nozzle assembly;
- wherein
(i) the rear housing comprises; a first barrel, having a first diameter;
a first end;
a second end;
a first internal chamber;
a first piercer, attached to the second end of the first barrel, having a first fluid passageway; and
a first plunger, having a first end and a second end, located at least partially within the first internal chamber and under pressure moveable therethrough; anda second barrel having a second diameter;
a first end;
a second end;
a second internal chamber;
a second piercer, located on the second end of the second barrel, having a second fluid passageway; and
a second plunger, having a first end and a second end, located at least partially within the second internal chamber and under pressure moveable therethrough;(ii) the front housing comprises; a third barrel, having a third diameter;
a first end;
a second end;
a third internal chamber;
a first piston having a third fluid passageway therethrough, located within the third internal chamber and under pressure moveable therethrough;
a first piercable barrier, located at the first end of the third barrel and suitably positioned to be pierced by the first piercer, thereby allowing fluid communication between the first internal chamber and the second internal chamber via the first fluid passageway and the third fluid passageway; and
a second piercable barrier, located at the second end of the third barrel; anda fourth barrel, having a fourth diameter;
a first end;
a second end;
a fourth internal chamber;
a second piston having a fourth fluid passageway therethrough, located within the fourth internal chamber and under pressure moveable therethrough;
a third piercable barrier, located at the first end of the fourth barrel and suitably positioned to be pierced by the second piercer, thereby allowing fluid communication between the second internal chamber and the fourth internal chamber via the second fluid passageway and the fourth fluid passageway; and
a fourth piercable barrier, located at the second end of the fourth barrel; and(iii) the nozzle assembly comprises; a fifth internal chamber;
having a first inlet with a third piercer affixed thereto, which comprises a fifth fluid passageway, and is suitably positioned at the first inlet to pierce the second piercable barrier and thereby allow fluid communication between the third internal chamber and the fifth internal chamber via the fifth fluid passageway;
a second inlet with a fourth piercer affixed thereto, which comprises a sixth fluid passageway, and is suitably positioned at the second inlet to pierce the fourth piercable barrier and thereby allow fluid communication between the fourth internal chamber and the fifth internal chamber via the sixth fluid passageway; and
an outlet;wherein the nozzle assembly is connected to the front housing;
the front housing is connected to the rear housing;
the first diameter is less than the third diameter;
the second diameter is less than the fourth diameter;
the first piercer is sized to block the first fluid passageway;
the second piercer is sized to block the second fluid passageway; and
the mechanical interlock is positioned to allow initially the first piercer to pierce the first barrier but not block the first fluid passageway; and
the mechanical interlock is positioned to initially allow the second piercer to pierce the second barrier but not block the second fluid passageway. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
- wherein
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19. A method of using an applicator to apply a composition to a surface;
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wherein the applicator comprises a rear housing, a front housing, a mechanical interlock and a nozzle assembly;
wherein(i) the rear housing comprises; a first barrel, having a first diameter;
a first end;
a second end;
a first internal chamber containing a first liquid;
a first piercer, attached to the second end of the first barrel, having a first fluid passageway; and
a first plunger, having a first end and a second end, located at least partially within the first internal chamber and under pressure moveable therethrough; anda second barrel having a second diameter;
a first end;
a second end;
a second internal chamber containing a second liquid;
a second piercer, located on the second end of the second barrel, having a second fluid passageway; and
a second plunger, having a first end and a second end, located at least partially within the second internal chamber and under pressure moveable therethrough;(ii) the front housing comprises; a third barrel, having a third diameter;
a first end;
a second end;
a third internal chamber containing a first solid;
a first piston having a third fluid passageway therethrough, located within the third internal chamber and under pressure moveable therethrough;
a first piercable barrier, located at the first end of the third barrel and suitably positioned to be pierced by the first piercer, thereby allowing fluid communication between the first internal chamber and the second internal chamber via the first fluid passageway and the third fluid passageway; and
a second piercable barrier, located at the second end of the third barrel; anda fourth barrel, having a fourth diameter;
a first end;
a second end;
a fourth internal chamber containing a second solid;
a second piston having a fourth fluid passageway therethrough, located within the fourth internal chamber and under pressure moveable therethrough;
a third piercable barrier, located at the first end of the fourth barrel and suitably positioned to be pierced by the second piercer, thereby allowing fluid communication between the second internal chamber and the fourth internal chamber via the second fluid passageway and the fourth fluid passageway; and
a fourth piercable barrier, located at the second end of the fourth barrel; and(iii) the nozzle assembly comprises; a fifth internal chamber;
having a first inlet with a third piercer affixed thereto, which comprises a fifth fluid passageway, and is suitably positioned at the first inlet to pierce the second piercable barrier and thereby allow fluid communication between the third internal chamber and the fifth internal chamber via the fifth fluid passageway;
a second inlet with a fourth piercer affixed thereto, which comprises a sixth fluid passageway, and is suitably positioned at the second inlet to pierce the fourth piercable barrier and thereby allow fluid communication between the fourth internal chamber and the fifth internal chamber via the sixth fluid passageway; and
an outlet;wherein the nozzle assembly is connected to the front housing;
the front housing is connected to the rear housing;
the first diameter is less than the third diameter;
the second diameter is less than the fourth diameter;
the first piercer is sized to block the first fluid passageway;
the second piercer is sized to block the second fluid passageway; and
the mechanical interlock is positioned to allow initially the first piercer to pierce the first barrier but not block the first fluid passageway; and
the mechanical interlock is positioned to initially allow the second piercer to pierce the second barrier but not block the second fluid passageway;comprising the steps of; advancing the first barrel towards the nozzle and into the third barrel, thereby piercing the first barrier, placing the first internal chamber in fluid communication with the third internal chamber; advancing the first plunger towards the nozzle, thereby expelling the first liquid into the third internal chamber, forming a first mixture of the first liquid and the first solid; advancing the second barrel towards the nozzle and into the fourth barrel, thereby piercing the second barrier, placing the second internal chamber in fluid communication with the fourth internal chamber; advancing the second plunger towards the nozzle, thereby expelling the second liquid into the fourth internal chamber, forming a second mixture of the first liquid and the first solid; advancing the third barrel towards the nozzle, thereby piercing the third barrier and placing the third internal chamber in fluid communication with the fifth internal chamber; advancing the fourth barrel towards the nozzle, thereby piercing the fourth barrier, placing the fourth internal chamber in fluid communication with the fifth internal chamber; advancing the first piston and the second piston towards the nozzle, thereby causing the first mixture to mix with the second mixture in the fifth internal chamber, forming a pre-composition mixture; applying the pre-composition mixture to the surface, wherein the mixture gels to form the composition on the surface. - View Dependent Claims (20)
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Specification