Methods and Compositions For Altering Biological Surfaces

• US 20100015068A1
• Filed: 07/06/2007
• Published: 01/21/2010
• Est. Priority Date: 07/06/2006
• Status: Abandoned Application

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Karp, Jeffrey M., Berry, David A., Gu, Frank X., Langer, Robert S., Khademhosseini, Alireza
• Application Number:
  US12/309,049
• Publication Number:
  US 20100015068A1
• Time in Patent Office: Days
• US Class Current: 424/57
• CPC Class Codes: A61K 2800/412 Microsized, i.e. having sizes between 0.1 and 100 microns
• CPC Class Codes: A61K 2800/94 Involves covalent bonding to the substrate
• CPC Class Codes: A61K 6/17 Particle size
• CPC Class Codes: A61K 6/20 Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
• CPC Class Codes: A61K 6/69 Medicaments
• CPC Class Codes: A61K 6/75 Apatite
• CPC Class Codes: A61K 6/816 comprising titanium oxide
• CPC Class Codes: A61K 6/818 comprising zirconium oxide
• CPC Class Codes: A61K 6/853 Silicates
• CPC Class Codes: A61K 6/864 Phosphate cements apatite A61K6/838
• CPC Class Codes: A61K 6/873 Carbonates
• CPC Class Codes: A61K 8/11 Encapsulated compositions
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/88 Polyamides
• CPC Class Codes: A61L 24/02 containing inorganic materials
• CPC Class Codes: A61P 19/10 for osteoporosis
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: C08L 1/00 Compositions of cellulose, modified cellulose or cellulose derivatives
• CPC Class Codes: C08L 1/286 substituted with acid radicals, e.g. carboxymethyl cellulose [CMC] C08L1/282 takes precedence
• CPC Class Codes: C08L 33/02 Homopolymers or copolymers of acids; Metal or ammonium salts thereof
• CPC Class Codes: C08L 5/00 : Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
• CPC Class Codes: C08L 5/08 : Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
• CPC Class Codes: Y10T 428/2982 : Particulate matter [e.g., sphere, flake, etc.]

Abstract

Compositions, methods and kits are provided for altering the properties of a biological surface using particles such as, for instance, calcium based particles in combination with an agent that binds to the biological surface. Properties such as color, sheen, texture, strength, and odor of biological surfaces such as teeth and bone are alterable.

Claims

1. A composition comprising a calcium particle linked to a hydroxyapatite binding agent.

5. The composition of claim 1 wherein the calcium particle is calcium carbonate.

7. The composition of claim 1 wherein the diameter of the calcium particle is about 5 nm to about 500 nm.

10. The composition of claim 1 wherein the particle comprises an aggregate of particles.

18. The composition of claim 1 wherein the composition comprises a dentifrice including a mouthwash, a mouthrinse, a toothpaste, a tooth powder, a tooth hardener, an antiplaque composition, a dental cream, a dental floss, a liquid, a gel, a chewing gum, including a center-filled gum, a confectionary, including mints, lozenges.

22. The composition of claim 1 wherein the calcium particle is further linked to a modifying ligand and a hydroxyapatite binding agent.

24. The composition of claim 22 wherein the modifying ligand comprises a stealth ligand.

2-4. -4. (canceled)

6. (canceled)

8-9. -9. (canceled)

11-17. -17. (canceled)

19-21. -21. (canceled)

23. (canceled)

25-26. -26. (canceled)

27. A composition comprising a solution of particles linked to a hydroxyapatite binding agent, wherein the particle is not incorporated into a liposome.

31. The composition of claim 27 further comprising a biodegradable polymer.

32. The composition of claim 27 wherein the particle consists essentially of water insoluble components.

28-30. -30. (canceled)

33. A method comprising

contacting a tooth of a subject with a composition comprising a calcium particle linked to a hydroxyapatite binding agent, to bind the calcium particle to the tooth.

34. The method of claim 33 wherein the binding of the particle to the tooth promotes whitening of the tooth.

38. The method of claim 33 wherein the method further comprises a method for treating a disease selected from the group consisting of peridontal disease and gingivitis.

35-37. -37. (canceled)

39. (canceled)

40. A method comprising

contacting a tooth of a subject with a particle linked to a hydroxyapatite binding agent, wherein the particle is not incorporated into a liposome, to bind the particle to the tooth.

41-46. -46. (canceled)

47. A method comprising

(a) applying to the tooth of a subject a biological surface modifying agent, and

(b) contacting the biological surface modifying agent with a composition comprising a calcium particle linked to a binding agent wherein the binding agent binds to the biological surface modifying agent on the surface of the tooth to bind the particle to the tooth.

48-56. -56. (canceled)

57. A method comprising

contacting an oral cavity of a subject with a calcium particle linked to a saliva or bacterial binding agent to bind the calcium particle to saliva or bacteria on a tooth surface.

58-71. -71. (canceled)

72. A method for delivering calcium particles to bone comprising administering to a subject a calcium particle linked to both a modifying ligand and a hydroxyapatite binding agent, to deliver the calcium particle to the bone.

73. The method of claim 72 wherein the modifying ligand comprises a stealth ligand.

75. The method of claim 72 wherein the particle further comprises an agent, factor or drug.

74. (canceled)

76-102. -102. (canceled)

103. A method for treating osteoporosis comprising administering to a subject having or at risk of having osteoporosis an effective amount of a calcium particle linked to both a modifying ligand and a hydroxyapatite binding agent to treat osteoporosis in the subject.

104-132. -132. (canceled)

133. A composition comprising a water insoluble particle containing an agent that promotes targeting of the particle to a calcium containing substrate.

135. The composition of claim 133 wherein the particle further comprises a drug.

136. The composition of claim 135 wherein the drug is an anti-neoplastic agent.

137. The composition of claim 133 wherein the particle further comprises a bone targeting agent which targets a bone marrow specific membrane surface receptor.

134. The composition of 133 where the calcium containing substrate is hydroxyapatite.

138. A composition comprising a solution of particles linked to a mineral binding agent, wherein the particle is not incorporated into a liposome.

139. A method comprising

contacting a tooth of a subject with a composition comprising a calcium particle linked to a mineral binding agent, to bind the calcium particle to the tooth.

140. A method comprising

(a) applying to a tissue a biological surface modifying agent, and

(b) contacting the biological surface modifying agent with a composition comprising a calcium particle linked to a binding agent wherein the binding agent binds to the biological surface modifying agent on the surface of the tissue to bind the particle to the tissue

141. A method for delivering a drug to bone, comprising

contacting a bone tissue with a composition comprising a water insoluble particle containing an agent that promotes targeting of the particle to hydroxyapatite, wherein the particle further comprises a drug.