INJECTABLE DEPOT COMPOSITIONS AND IT'S PROCESS OF PREPARATION
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Abstract
Novel injectable depot compositions are provided comprising at least one active agent(s) optionally with one or more pharmaceutically acceptable excipient(s) in the form of a multi-component system preferably comprising at least two components which when administered to a subject in need thereof forms an in situ gel depot or implant at the site of injection upon contact with body fluids. Also described are process for preparation of such compositions and method of using such compositions.
60 Citations
62 Claims
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1-32. -32. (canceled)
- 33. A novel injectable composition exhibiting minimal burst release comprising at least one active agent(s) or its pharmaceutically acceptable salts, derivatives, isomers, polymorphs, solvates, hydrates, analogues, enantiomers, tautomeric forms or mixtures thereof, at least one biodegradable polymer(s), at least one viscosity enhancing agent(s) and optionally one or more pharmaceutically acceptable excipient(s), wherein the compositions are formulated as reconstitutable biodegradable microparticles or nanoparticles, and wherein the said compositions are in the form of a multi-component system preferably comprising at least two components, and wherein the said compositions form an in situ gelling depot or an implant upon administration in vivo upon contact with body fluids therefore providing a prolonged release of the active agent(s) for extended periods of time.
Specification