Drug Delivery Medical Device
First Claim
1. A medical device comprising:
- a substrate; and
a coating on at least a portion of said substrate,wherein the coating comprises a plurality of layers, wherein at least one layer comprises a pharmaceutical agent that is crystalline, andwherein the device is adapted to free at least a portion of the coating from the substrate upon stimulation of the coating.
6 Assignments
0 Petitions
Accused Products
Abstract
Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.
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Citations
29 Claims
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1. A medical device comprising:
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a substrate; and a coating on at least a portion of said substrate, wherein the coating comprises a plurality of layers, wherein at least one layer comprises a pharmaceutical agent that is crystalline, and wherein the device is adapted to free at least a portion of the coating from the substrate upon stimulation of the coating. - View Dependent Claims (6, 11, 12, 13, 14)
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2. A medical device comprising:
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a substrate; and a coating on at least a portion of said substrate, wherein said coating is at least partially continuous, has at least one portion conformal to the substrate, and comprises a pharmaceutical agent that is crystalline, and wherein the device is adapted to free at least a portion of the coating from the substrate upon stimulation of the coating.
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3. A medical device comprising:
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a substrate; and a coating on at least a portion of said substrate, wherein said coating comprises an active agent, and wherein the device is adapted to free greater than 35% of the coating from the substrate upon a single stimulation of the coating. - View Dependent Claims (7)
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4. A medical device comprising:
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a substrate; and a coating on at least a portion of said substrate, wherein said coating comprises an active agent, wherein the coating is patterned, and wherein at least a portion of the coating is adapted to free from the substrate upon stimulation of the coating. - View Dependent Claims (8)
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5. A medical device comprising:
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a substrate; and a coating on at least a portion of said substrate, wherein the coating comprises a plurality of layers, wherein at least one layer comprises an active biological agent, and wherein the device is adapted to free at least a portion of the coating from the substrate upon stimulation of the coating. - View Dependent Claims (9, 10, 15)
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16. A method comprising:
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providing a medical device, wherein the medical device comprises a substrate and a coating on at least a portion of said substrate, and wherein the coating comprises a plurality of layers, wherein at least one layer comprises a pharmaceutical agent that is crystalline, and freeing at least a portion of the coating from the substrate upon stimulating the coating with a stimulation. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28)
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17. A method comprising:
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providing a medical device, wherein the medical device comprises a substrate and a coating on at least a portion of said substrate, wherein said coating is at least partially continuous, has at least one portion conformal to the substrate, and comprises a pharmaceutical agent that is crystalline, and freeing at least a portion of the coating from the substrate upon stimulating the coating with a stimulation.
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18. A method comprising:
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providing a medical device, wherein the medical device comprises a substrate and a coating on at least a portion of said substrate, and wherein said coating comprises an active agent, and freeing greater than 35% of the coating from the substrate upon stimulating the coating with a stimulation.
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19. A method comprising:
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providing a medical device, wherein the medical device comprises a substrate and a coating on at least a portion of said substrate, wherein said coating comprises an active agent, and wherein the coating is patterned, and freeing at least a portion of the coating from the substrate upon stimulating the coating with a stimulation.
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20. A method comprising:
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providing a medical device, wherein the medical device comprises a substrate and a coating on at least a portion of said substrate, and wherein the coating comprises a plurality of layers, wherein at least one layer comprises an active biological agent, and freeing at least a portion of the coating from the substrate upon stimulating the coating with a stimulation. - View Dependent Claims (29)
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Specification