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COMPOSITIONS AND METHODS FOR POTENTIATED ACTIVITY OF BIOLOGICALLY ACTIVE MOLECULES

  • US 20100015218A1
  • Filed: 02/15/2008
  • Published: 01/21/2010
  • Est. Priority Date: 02/16/2007
  • Status: Abandoned Application
First Claim
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1. A composition comprising a first lipid nanoparticle (LNP) vehicle and a second lipid nanoparticle (LNP) vehicle each having size between about 50 nm and about 500 nm, wherein:

  • a) each vehicle comprises a cationic lipid, a neutral lipid, and a PEG-lipid;

    b) the first LNP vehicle further comprises one or more short interfering nucleic acid (siNA) molecules comprising a sense strand and a complementary antisense strand, each strand having between 15 and 30 nucleotides in length, wherein the antisense strand comprises between 15 and 30 nucleotides that are complementary to a mammalian RNA sequence and the sense strand comprises between 15 and 30 nucleotides of said mammalian RNA sequence; and

    c) the second LNP vehicle further comprises one or more carrier molecules comprising a nucleic acid sequence of at least 15 nucleotides that is not complementary to said mammalian RNA sequence;

    wherein the lipids of the first LNP vehicles are the same as or different from the second LNP vehicle.

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