Treatment of nail infections with no

• US 20100015253A1
• Filed: 05/28/2009
• Published: 01/21/2010
• Est. Priority Date: 08/03/2001
• Status: Active Grant

• Current Assignee: Aberdeen University
• Original Assignee: Aberdeen University
• Inventors: Benjamin, Nigel
• Granted Patent: US 9,381,381 B2
• Time in Patent Office: Days
• US Class Current: 424/718
• CPC Class Codes: A61K 31/04 Nitro compounds
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 47/38 Cellulose; Derivatives thereof
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 9/0012 Galenical forms characterised by the site of application
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61Q 3/00 Manicure or pedicure preparations

Abstract

Nitrogen oxide generating compositions are useful in the treatment of subungual infections, as NO has surprisingly been found to be able to penetrate the nail to exert an anti-fungal effect.

Claims

1-25. -25. (canceled)

26. A method for the treatment or prophylaxis of a subungual infection in a patient, the method comprising:

generating nitrogen oxide by combining a nitrite and an organic acid, wherein the nitrite and the organic acid are separately disposed from each other prior to being combined, and combining the nitrite and the organic acid forms a composition, wherein the composition is generated on, or applied to, a nail of the patient in an amount that effectively treats an infection under the nail.

27. The method according to claim 26, wherein the organic acid is present in sufficient quantity that the composition formed by combining the nitrite and the organic acid is at a pH of 5.5, or below.

28. The method according to claim 26, wherein the organic acid is selected from:

formic acid, malic acid, maleic acid, acetic acid, lactic acid, citric acid, benzoic acid, tartaric acid and salicylic acid, ascorbic acid, ascorbyl palmitate, and mixtures thereof.

29. The method according to claim 26, wherein the nitrite is selected from the alkali metal nitrites and the alkaline earth metal nitrites.

30. The method according to claim 29, wherein the nitrite is selected from:

sodium, potassium, magnesium and barium nitrites.

31. The method according to claim 26, wherein the organic acid comprises citric acid and the nitrite comprises sodium nitrite, at least one being present in an aqueous vehicle.

32. The method according to claim 26, wherein the subungual infection is onychomycosis.

33. The method according to claim 26, wherein the nitrite is formulated with an excipient selected from:

Eudragits, carbopol, carboxymethylcellulose, hydroxymethylcellulose, and mixtures thereof.

34. The method according to claim 26, wherein the organic acid is formulated with an excipient selected from:

carbopol, carboxymethylcellulose, hydroxymethylcellulose, methylcellulose, and mixtures thereof.

35. The method according to claim 26, wherein the organic acid and the nitrite are separately disposed in aqueous based formulations prior to being combined.

36. The method according to claim 35, wherein each preparation is in a form separately selected from gels, creams, lotions, ointments and paints suitable for mixing each with the other.

37. The method according to claim 26, wherein the organic acid and the nitrite are each separately formulated as a gel, paint or lacquer prior to being combined.

38. The method according to claim 26, wherein, prior to being combined, the organic acid and the nitrite are each separately formulated as a liquid or gel which, when mixed, solidify or form a gel or paint.

39. The method according to claim 26, wherein the nitrite is approximately 0.5 to 30%, by weight, of the composition formed by combining the nitrite and the organic acid.

40. The method according to claim 39, wherein the nitrite is 5 to 15%, by weight, of the composition formed by combining the nitrite and the organic acid.

41. The method according to claim 26, wherein the organic acid is approximately 5 to 30%, by weight, of the composition formed by combining the nitrite and the organic acid.

42. The method according to claim 41, wherein the organic acid is approximately 10 to 15%, by weight, of the composition formed by combining the nitrite and the organic acid.

43. The method according to claim 26, wherein the composition formed by combining the nitrite and the organic acid is applied to an infected nail in an effective amount.